Clinical trials: MYOPATHY
Ledderhose Disease
Ledderhose Disease: Radiotherapy or Not?
The aim of the LedRad trial is to determine the efficacy and durability of radiotherapy as treatment for patients with Ledderhose disease and to compare this to the natural course of Ledderhose disease.
- Trial name
- LedRad (NCT03507010)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- University Medical Center Groningen
Facioscapulohumeral Muscular Dystrophy
Study of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD)
Study A083-02 is a multi-center, Phase 2 study to evaluate the safety, tolerability, pharmacodynamics (PD), efficacy, and pharmacokinetics (PK) of locally-acting ACE-083 in patients with Facioscapulohumeral muscular dystrophy…
- Trial name
- NCT02927080
- Testing
- ACE-083
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 95 people
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Fibromyalgia
Impact of the Placebo Effect on the Effects of Trancranial Direct Current Stimulation in Fibromyalgia
Fibromyalgia (FM) is a syndrome characterized by generalized musculoskeletal pain, fatigue, non-restorative sleep, cognitive alterations, depressive and neurovegetative symptoms.
- Trial name
- NCT05903079
- Testing
- s-Tdcs
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cerebral Palsy Spastic Diplegia
Effect of Botulinum Toxin on Selective Motor Control and Pain in Diplegic Cerebral Palsy
The aim of this study is to investigate the effects of Botulinum Neurotoxin-A (BoNT-A) injection applied to spastic muscles on pain sensation and Selective Motor Control (SMC) in cases diagnosed with diplegic spastic Cerebral…
- Trial name
- NCT06583343
- Testing
- OnabotulinumtoxinA, Conventional Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Carpal Tunnel Syndrome, Trigger Finger
Tourniquet vs. No Tourniquet for Carpal Tunnel and Trigger Finger Release
Background: Trigger finger and carpal tunnel syndrome are two of the most common conditions treated by the hand surgeon. During these procedures, a tourniquet is often used to minimize bleeding and improve visualization of the…
- Trial name
- NCT04354415
- Testing
- Carpal tunnel or trigger finger release
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Duchenne Muscular Dystrophy (DMD)
Peabody Developmental Motor Scaling In Children With Period Duchenne Muscular Dystrophy
To perform the reliability and validity study of the Peabody Developmental Motor Scale (Peabody Developmental Motor Scales-2) in children with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT05990608
- Testing
- Peabody Developmental Motor Scales-2, PDMS
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Stroke, Spasticity, Muscle
Effects of PNF and Static Stretching on Architecture and Viscoelastic Properties of Hemiplegic Elbow
The patients who were diagnosed with stroke in governmental/university/private hospitals, and who needed rehabilitation because of the increased flexor tone in the elbow joint, decreased range of motion and/or decreased function…
- Trial name
- NCT05626790
- Testing
- Exercise, PNF Stretching, Prolonged Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University - Cerrahpasa
Muscles, Exercise
The Role of Arnica on Muscle Pain Following Eccentric Exercise
Arnica in a topical gel formulation will be compared to a placebo to determine whether it decreases muscle soreness following leg exercise when applied to the legs.
- Conditions
- Muscles, Exercise, Arnica
- Trial name
- Arnica (NCT00504010)
- Testing
- Arnica Montana
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Achilles Tendinitis
A Pilot Study: Treatment of Achilles Tendinopathy With Platelet-Rich Plasma Therapy
The overall goal of this proposal is to correlate ultrasound elastography technique with more standard clinically based outcome measures within the setting of a small sample sized group of patients affected by moderate-to…
- Trial name
- NCT01911650
- Testing
- Autologous Platelet Rich Plasma, Ultrasound Imaging, Quality of Life Questionnaires
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Temporomandibular Disorder
Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain
Temporomandibular disorders (TMDs) are one of the most common muco-skeletal disorders, seen in the dental clinics. Many factors work together to initiate or aggravate the condition, so it is a multifactorial disorder.
- Trial name
- NCT04066426
- Testing
- naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Yuzuncu Yil University
Myotonic Dystrophy 1
DM-IMT - Controlled, Randomized, Three-arm Intervention Study on the Safety and Efficacy of Regular Respiratory Muscle Training in Patients With Myotonic Dystrophy Type 1
For some diseases, regular respiratory muscle training could delay the start of ventilation. For DM1, however, there are no clinically high-quality studies.
- Trial name
- DM-IMT (NCT04052958)
- Testing
- IMT - inspiratory muscle training
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- LMU Klinikum
Back Pain, Osteoarthritis
Strategies for Prescribing Analgesics Comparative Effectiveness Trial
Chronic musculoskeletal pain conditions are among the most prevalent conditions in VA primary care. Over the past two decades, improved clinical attention to pain has been associated with exponentially greater use of long-term…
- Trial name
- SPACE (NCT01583985)
- Testing
- Opioid-intensive prescribing strategy, Opioid-avoidant prescribing strategy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- VA Office of Research and Development
Dysmenorrhea Primary, Central Sensitisation
Myofascial Release Technique in Women With Primary Dysmenorrhea
It has been found that women with dysmenorrhea have active trigger points, particularly in the rectus abdominis, oblique abdominal muscles, quadratus lumborum, and paraspinal muscles.
- Conditions
- Dysmenorrhea Primary, Central Sensitisation, Myofascial Trigger Point Pain, Menstrual Discomfort
- Trial name
- NCT06492148
- Testing
- Myofascial Release
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gazi University
Dermatomyositis, Adult Type
Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis
With limited treatment options available for dermatomyositis, the investigators hypothesize that apremilast, a phosphodiesterase-4 (PDE-4) inhibitor, is a safe and efficacious add-on treatment in patients with refractory…
- Trial name
- NCT03529955
- Testing
- Apremilast 30mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Tulane University
Polymyalgia Rheumatica
A Study to Evaluate the Efficacy of Tocilizumab as a Remission-Induction and Glucocorticoid-Sparing Regimen in Subjects With New-Onset Polymyalgia Rheumatica (PMR- SPARE)
The purpose of this study is to assess the efficacy of a tocilizumab-based regimen compared with placebo on top of rapidly tapered glucocorticoid treatment in a double- blind, controlled fashion, focussing on glucocorticoid-free…
- Trial name
- NCT03263715
- Testing
- Tocilizumab Prefilled Syringe [Actemra], Glucocorticoids
- Where
- 3 sites in Austria
- Volunteers
- 39 people
- Sponsor
- Medical University of Vienna
Lateral Epicondylitis, Tennis Elbow
Comparison of the Efficacy of Mesotherapy and Extracorporeal Shock Wave Therapy in Patients With Lateral Epicondylitis
The goal of this clinical trial is to investigate the efficacy of mesotherapy in patients with lateral epicondylitis and to determine whether it is as effective as extracorporeal shock wave therapy (ESWT).
- Trial name
- NCT07043335
- Testing
- Extracorporeal Shock Wave Therapy, Mesotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Back Pain, Muscle Pain
Transcutaneous Electrical Nerve Stimulation for Back Pain in the Emergency Department (TENS-ED)
The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) to reduce pain scores for patients with acute back pain in an ambulatory emergency department (ED) population will be examined in this dual-center, cluster…
- Conditions
- Back Pain, Muscle Pain, Acute Pain, Lower Back Pain
- Trial name
- TENS-ED (NCT05601843)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sam Brophy
Irritable Bowel Syndrome (IBS), Fibromyalgia (FM)
Evaluating the Added Benefit of Osteopathic Care to a Flexi-FODMAP Diet in Fibromyalgia Patients With Irritable Bowel Syndrome
Dietary modifications are often recommended as first-line treatment for irritable bowel syndrome, with the FODMAP diet being the most effective intervention to improve global gastrointestinal symptoms.
- Trial name
- POISE-IBS-RCT (NCT07176078)
- Testing
- Osteopathic care, Flexi-FODMAP Diet
- Where
- Belgium
- Volunteers
- 96 people
- Sponsor
- Universitair Ziekenhuis Brussel
Arthritis, Gout
Phone-Based Based Walk With Ease Program for Adults With Arthritis
The objective of this study is to examine the short-term (6-weeks and 6 months) and long-term (1 year) effects of a phone-based version of Walk With Ease intervention.
- Conditions
- Arthritis, Gout, Fibromyalgia, Rheumatoid Arthritis
- Trial name
- NCT05289544
- Testing
- Phone-Based Walk With Ease
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
MELAS Syndrome, Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
A Study to Assess TTI-0102 vs Placebo in MELAS Patients
This is a randomized, double-blind, placebo-controlled study. Prior to treatment, patients will undergo a screening visit. If eligible, each subject will return for a Day 1 visit and will receive their first dose of…
- Trial name
- NCT06644534
- Testing
- TTI-0102
- Where
- 2 sites in France, Netherlands
- Volunteers
- 9 people
- Sponsor
- Thiogenesis Therapeutics, Inc.
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