Clinical trials: MYOPATHY
Musculoskeletal Pain, Fibromyalgia
Neural Mechanisms of Light Driven Analgesia
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical…
- Conditions
- Musculoskeletal Pain, Fibromyalgia, Healthy Controls Group - Age and Sex-matched
- Trial name
- NCT07245303
- Testing
- S-cone modulating visual stimulus, Equal Energy White Visual Stimulus, Green light visual stimulus (S-OFF)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Fatigue Syndrome
Pilot Study for the NorCAPITAL Trial
The aim of this pilot study for the NorCAPITAL trial is to investigate the feasibility and safety of the drug clonidine in adolescent chronic fatigue syndrome (CFS).
- Trial name
- NCT01507701
- Testing
- Clonidine
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- Oslo University Hospital
Childhood Soft Tissue Sarcoma, Childhood Liver Cancer
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of liposomal doxorubicin in treating children who have…
- Conditions
- Childhood Soft Tissue Sarcoma, Childhood Liver Cancer, Bone Cancer, Brain Tumor
- Trial name
- NCT00019630
- Testing
- doxorubicin HCl liposome
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Trigger Point Pain, Myofascial
Strain Counterstrain Technique and Graston Technqiue on Quadratus Lumborum Trigger Points
Poor body mechanics and posture affects body positioning and stresses quadratus lumborum muscle which ultimately leads to myofascial trigger points in muscle.
- Trial name
- NCT06986707
- Testing
- Strain counterstrain technique, Graston technique
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Nocturnal Leg Cramps, Myofascial Pain Syndrome
Exercise and Dry Needling Treatment Combination in Nocturnal Calf Cramps
The Investigators aim to evaluate the effectiveness of dry needling treatment in addition to stretching exercises on cramp duration, cramp intensity, cramp frequency, sleep quality, and sensitivity of myofascial trigger points in…
- Trial name
- NCT04789811
- Testing
- Stretching exercise, Dry needling
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kars State Hospital
Fibromyalgia, Multiple Sclerosis
e-Mobile Tablet for People With Chronic Conditions
Maintaining a healthy diet and engaging in routine physical activity may help decrease severity of symptoms, prevent secondary conditions, and slow functional decline in people with disabling neuromusculoskeletal conditions.
- Conditions
- Fibromyalgia, Multiple Sclerosis, Osteoarthritis, Sjögren's Syndrome
- Trial name
- NCT02833311
- Testing
- Computer Tablet Group, Paper and Pencil Group, Contact Control Group
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Case Western Reserve University
Duchenne Muscular Dystrophy (DMD)
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping
The primary purpose of this study is to evaluate the safety, tolerability, and dystrophin protein levels in muscle tissue following multiple intravenous (IV) doses of DYNE-251 in participants with Duchenne muscular dystrophy…
- Trial name
- DELIVER (NCT05524883)
- Testing
- DYNE-251
- Where
- 30 sites in United States, Australia and 7 more
- Volunteers
- 86 people
- Sponsor
- Dyne Therapeutics
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Restrictive Burn Scars
Pilot Study of Azficel-T for the Treatment of Restrictive Burn Scars
This Phase II, double-blind, randomized, placebo-controlled pilot study is designed to determine whether injection of autologous fibroblasts can increase the mobility (decrease the restriction) of burn scars.
- Trial name
- NCT01858753
- Testing
- Autologous fibroblasts
- Where
- 9 sites in United States
- Volunteers
- 5 people
- Sponsor
- Castle Creek Biosciences, LLC.
Ear Protective Devices, Temporomandibular Joint Disorders
The Use of Earplugs on Temporomandibular Joint
The term temporomandibular joint disorder (TMD) refers to a group of disorders affecting the temporomandibular joint and/or muscles of mastication. Typical symptoms are; joint noises, pain, and limited mouth opening.
- Conditions
- Ear Protective Devices, Temporomandibular Joint Disorders, Physical Therapy Modalities
- Trial name
- NCT05362877
- Testing
- Earplug, occlusal splint, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Temporomandibular Disorders (TMD)
Journaling Intervention for Temporomandibular Disorder (TMD) and Chronic Overlapping Pain
The goal of this clinical trial is to learn whether a 2-week gratitude journaling activity is feasible and acceptable for individuals with Temporomandibular Disorder (TMD) and chronic overlapping pain.
- Trial name
- NCT06977100
- Testing
- Gratitude, General Wellness
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Anterior Cruciate Ligament Injuries, Muscle Weakness
Changes in the Force-velocity Relationship of Knee Muscles After ACL Reconstruction
Anterior cruciate ligament (ACL) tear is a frequent and devastating injury in sport, especially in pivoting-contact disciplines.
- Trial name
- FoVeA (NCT05712109)
- Testing
- Follow-up after Anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
Muscle Weakness, Critical Illness Myopathy
CPAx: Responsiveness and Minimal Clinically Important Difference
Intensive care unit (ICU) acquired weakness is a common complication associated with long-term physical impairments in survivors of a critical illness.
- Conditions
- Muscle Weakness, Critical Illness Myopathy, Critical Illness Polyneuropathy, Critical Illness Polyneuromyopathy
- Trial name
- NCT06419699
- Where
- 3 sites in Australia, Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain, Back, Neck Pain
Evaluation of Text Neck Syndrome and Hand Grip Force in Smart Phone Addiction Among Students of Jazan University
This study will be conducted in the Department of physical therapy, College of Applied Medical Sciences,Jazan University, to investigate text neck syndrome and hand grip force in smart phone addiction among students of jazan…
- Conditions
- Pain, Back, Neck Pain, Postural; Strain, Myofascial Pain Syndrome
- Trial name
- NCT03757520
- Testing
- Pain Pressure Threshold, Hand Grip Force
- Where
- Saudi Arabia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Wafaa Mahmoud Amin
Anterior Cruciate Ligament Rupture, Tendon Injuries
Shear-Wave Elastography of Regenerated Hamstring Tendons After ACL Reconstruction (SWE-ACL)
Anterior cruciate ligament (ACL) reconstruction using autologous hamstring tendon grafts is a commonly performed procedure. Although the semitendinosus and gracilis tendons demonstrate regeneration at the donor site, the…
- Conditions
- Anterior Cruciate Ligament Rupture, Tendon Injuries, Muscle Weakness
- Trial name
- SWE-ACL (NCT07555782)
- Testing
- Shear-Wave Elastography Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Tendinopathy, Patellar Ligament
PRP vs PRP Plus IGF for Patellar Tendinosis
The purpose of this study is to compare two different platelet-rich plasma (PRP) injections for patellar tendinosis. Aim: To perform a randomized, double blinded study comparing the clinical effect of PRP versus PRP +…
- Conditions
- Tendinopathy, Patellar Ligament, Platelet-Rich Plasma
- Trial name
- NCT04350827
- Testing
- Platelet Rich Plasma, Platelet Rich Plasma plus IGF
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ohio State University
Myofascial Pain Syndrome
Shockwave Effectiveness in Myofascial Pain of the Upper Trapezius Muscle
Focused shockwaves are generated electrically, either within the applicator (electrohydraulic technique), or externally to it in the focal zone (electromagnetic or piezoelectric techniques), and then propagate to a designated…
- Trial name
- NCT04121130
- Testing
- F-ESWT Group
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación Garcia Cugat
Postpoliomyelitis
Brain Physiology in Polio Survivors
OBJECTIVE: Many persons who survive poliomyelitis develop pain, weakness, and fatigue many decades later. It is not known why some persons develop this syndrome and others do not.
- Trial name
- NCT00080600
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Exertional Compartment Syndrome
Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections.
The goal of this pilot triple-blind randomized clinical trial is to determine the effectiveness of intra-muscular botulism injection for treatment of lower leg anterolateral chronic exertional compartment syndrome (CECS).
- Trial name
- NCT05765071
- Testing
- Botulinum toxin A, Normal saline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Solid Tumor, Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations
Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors
The objective of this study is to determine the safety, pharmacokinetics, maximum tolerated dose/recommended Phase 2 dose, and efficacy of PLX7486.
- Conditions
- Solid Tumor, Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations, Tenosynovial Giant Cell Tumor
- Trial name
- NCT01804530
- Testing
- PLX7486 TsOH
- Where
- 4 sites in United States
- Volunteers
- 59 people
- Sponsor
- Plexxikon
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