Clinical trials: MYOPATHY
Inclusion Body Myositis (IBM)
Rapamycine vs Placebo for the Treatment of Inclusion Body Myositis
Sporadic Inclusion Body Myositis (IBM) is the most frequent inflammatory myopathy in patients over 50. It is a slowly progressive, but today untreatable (notably by classical immunosuppressants) disease.
- Trial name
- RAPAMI (NCT02481453)
- Testing
- Rapamycin
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Fibromyalgia, Sleep Disorder
Fibromyalgia and Sleep Disorder Treatment
This longitudinal study will investigate impact of improved sleep quality on chronic pain, fibromyalgia and how the disrupted sleep pattern alters the neuroenvironment.
- Trial name
- HOPES (NCT06786845)
- Testing
- Treatment lege artis
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Fibromyalgia (FM), Alexithymia
Alexithymia Levels in Fibromyalgia
The primary aim of this study was to investigate the changes in alexithymia levels in fibromyalgia patients over a six-month period following a combined treatment and to assess the relationship between changes in fibromyalgia…
- Trial name
- NCT06841302
- Testing
- Fibromyalgia Agents
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Ultrasound, Muscle Disease
Role of Ultrasound in Diagnosis of Muscle Diseases
The study aims to provide a timely update on the role of combining clinical and neuromuscular ultrasound assessments in diagnosis and follow-up of various muscle diseases in clinical practice over 12 months period, and…
- Trial name
- NCT04233255
- Testing
- Neuromuscular Ultrasound (US), Electrophysiological studies, Seum CPK, CK-MM levels, Lactate dehydrogenase and alanine aminotransferase.
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post-mastectomy Pain Syndrome, Myofascial Pain Syndrome
Trigger Point Injections for Post-Mastectomy Pain Syndrome
Post-Mastectomy Pain Syndrome (PMPS) is a chronic pain that persists for more than three months after a surgical breast procedure. It has 11-70% incidence in patients that underwent a breast surgery.
- Conditions
- Post-mastectomy Pain Syndrome, Myofascial Pain Syndrome, Trigger Point Pain, Myofascial, Breast Cancer
- Trial name
- NCT04267315
- Testing
- Trigger point injection, Subcutaneous saline injection, Comprehensive Rehabilitation program
- Where
- 2 sites in Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Lupus Erythematosus, Systemic, Foot Orthoses
Effect of Insoles in Patients With Systemic Lupus Erythematosus
Demonstrate that custom-made insoles improve painful symptomatology, health and foot function in subjects with SLE and podiatric involvement.
- Conditions
- Lupus Erythematosus, Systemic, Foot Orthoses, Musculoskeletal Pain
- Trial name
- EISLE (NCT04098055)
- Testing
- Custom-Made Foot Orthoses
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Seville
Fibromyalgia
Tai Chi Mind-Body Therapy for Fibromyalgia
The purpose of this study is to obtain preliminary data on the effects of Tai Chi on musculoskeletal pain, fatigue, sleep quality, psychological distress, physical performance,and health status in 60 patients with fibromyalgia.
- Trial name
- NCT00515008
- Testing
- Tai Chi Intervention, Control Intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Tufts Medical Center
Musculoskeletal Pain, Injuries
Modeling Post-traumatic Pain and Recovery: The SYMBIOME Longitudinal Cohort Study
This study will explore the contribution of stress-system activity to pain and functional disability in the acute stage of traumatic musculoskeletal injury, and to the maintenance of symptoms after 3, 6 and 12 months post-injury.
- Trial name
- SYMBIOME (NCT02711085)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Fatigue Syndrome, Coping
Coping With Chronic Fatigue Syndrome: Development of a Community-based Patient Education Program
The aim of the study is to develop, carry out, evaluate and measure the effects of a new patient education program for patients with Chronic Fatigue Syndrome (CFS)in primary healthcare.
- Conditions
- Chronic Fatigue Syndrome, Coping, Patient Education
- Trial name
- NCT01765725
- Testing
- Patient education program
- Where
- Norway
- Volunteers
- 146 people
- Sponsor
- Oslo University Hospital
Temporomandibular Joint Dysfunction, Myofunctional Therapy
Temporomandibular Joint Respiratory and Thoracic Region Added to Myofunctional Rehabilitation in Dysfunction Comparison of the Effects of Exercises
In the study, a questionnaire form will be applied to the participants using a face-to-face interview technique. Through the questionnaires, demographic characteristics, pain intensity, location of pain, symptoms of dysfunction…
- Conditions
- Temporomandibular Joint Dysfunction, Myofunctional Therapy, Rehabilitation Exercise
- Trial name
- NCT06883825
- Testing
- Myofunctional Therapy, Myofunctional Therapy + Respiratory Exercises, Myofunctional Therapy + Thoracic Region Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Merve Keskin
Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial.
- Conditions
- Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint, Anterior Disc Displacement
- Trial name
- LPCGF in TMDs (NCT07075276)
- Testing
- Liquid Phase Concentrated Growth Factor, Conventional arthrocentesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Horus University
Spasticity
Study of SPARC1103 in Subjects With Spasticity
Study of SPARC1103 in subjects with spasticity
- Trial name
- NCT02027025
- Testing
- SPARC1103 low dose, SPARC1103 high dose
- Where
- 23 sites in United States, Russia and 1 more
- Volunteers
- 142 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Stroke
Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients
The aim of this study will be to determine and compare the immediate and longer-term effects of combination of BoNT-A injection and mirror therapy vs combination of BoNT-A injection and robot-assisted therapy.
- Trial name
- NCT02749591
- Testing
- Botulinum Toxin Type A, Robot-assisted therapy, Mirror therapy
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Chang Gung Memorial Hospital
Spasticity, Muscle, Stroke Sequelae
Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)
Assessing the objective measurement of passive joint mobility (ROM) in the spastic upper limb with Jost's pattern III in patients with post-stroke spasticity after infiltration with BoNT-A allows to objectify the increase in…
- Conditions
- Spasticity, Muscle, Stroke Sequelae, Movement Disorders
- Trial name
- ROM-ICTUS (NCT05151874)
- Testing
- Abobotulinum toxin A
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Metabolomics, Critical Care
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation.
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE I (NCT03810768)
- Where
- 3 sites in Austria, Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Idiopathic Inflammatory Myopathies, ANCA-Associated Vasculitis
Clinical Study on the Targeted CD19 Universal CAR-T Cell Injection (RD06-04) for the Treatment of IIM and AAV
This is an open-label, investigator-initiated clinical trial (IIT) designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of RD06-04 in patients with refractory IIM and AAV.
- Trial name
- NCT06986018
- Testing
- RD06-04 Cell Injection Infusion
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University People's Hospital
Becker Muscular Dystrophy
Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study)
(-)-Epicatechin will be evaluated for the treatment of progressive muscle loss and impaired skeletal muscle function in Becker Muscular Dystrophy (BMD) patients.
- Trial name
- NCT01856868
- Testing
- (-)-epicatechin
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Craig McDonald, MD
Temporomandibular Joint Disorders
Stimulation of the Proprioceptive Trigeminocardiac Reflex
Study over muscular stretching to reduce pain the oral cavity.
- Trial name
- PTCRSTIM (NCT02908568)
- Testing
- Spring device, Mandible stimulator
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Azienda USL 12 Versilia
Musculoskeletal Pain
Piloting a Novel Peer Support Pain Self-Management Intervention (Project CONNECT)
The proposed study will test the feasibility and acceptability of an 8-week home-based reciprocal peer support pain self-management intervention (CONNECT) for women Veterans with chronic musculoskeletal pain.
- Trial name
- CONNECT (NCT04229134)
- Testing
- Project CONNECT
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Myofascial Pain Syndrome (MPS)
High-Intensity Laser Therapy for Trapezius Myofascial Pain (HILT-TRAP Study)
This study aims to evaluate the effectiveness of optimized High-Intensity Laser Therapy (HILT) compared with sham treatment in patients with trapezius myofascial pain syndrome.
- Trial name
- HILT-TRAP Stud (NCT07352787)
- Testing
- High-Intensity Laser Therapy
- Where
- Iraq
- Volunteers
- 104 people
- Sponsor
- Neveen Abd El Maksoad Kohaf
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