Clinical trials: MYOPATHY
Fibromyalgia
Anti-inflammatory Nutritional Intervention in Patients With Fibromyalgia
This is a randomized clinical trial, aimed to analyse the effects of a potentially anti-inflammatory nutritional intervention in disease assessment parameters, inflammatory markers, and quality of life of Fibromyalgia patients.
- Trial name
- NCT04007705
- Testing
- Anti-inflammatory and low FODMAPs diet, General healthy eating
- Where
- Portugal
- Volunteers
- 46 people
- Sponsor
- Universidade do Porto
Muscle Spasticity
Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury
A drug called AV650 (tolperisone HCl) will be given to patients who have spasticity following a spinal cord injury. This study has three purposes: 1. To determine whether AV650 is safe for patients with spinal cord injury; 2.
- Trial name
- NCT00531466
- Testing
- tolperisone HCl (AV650)
- Where
- 10 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Avigen
Non-Dystrophic Myotonia, Myotonia Congenita
Contractile Properties of Hypertrofic Muscles in Patients With Non-Dystrophic Myotonia
In myotonia congenita (MC), mutations in the CLCN1 gene coding a key chloride channel expressed in muscle cells cause myotonia. On examination, the myotonia can be demonstrated as delayed muscle relaxation of muscle contractions…
- Trial name
- NCT04799366
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement (Open-pilot)
The goal of this project is to conduct an open-pilot (N=30) to evaluate the feasibility, acceptability, and fidelity of a mind-body and activity program (GetActive+) with older adults with chronic pain.
- Trial name
- iHOPE (NCT05782231)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Chronic Back Pain, Depression
MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression
The proposed study seeks to evaluate effectiveness, implementation processes, and cost of MOTIVATE among older Veterans with chronic musculoskeletal (MSK) pain and comorbid depressive symptoms.
- Conditions
- Chronic Back Pain, Depression, Aging, Musculoskeletal Pain
- Trial name
- MOTIVATE_IIR (NCT05220202)
- Testing
- Behavioral Intervention Group (MOTIVATE)
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- VA Office of Research and Development
Sleep Bruxism, Adolescent
Effectiveness of Melissa Officinalis for the Treatment of Probable Sleep Bruxism in Children and Adolescents
Objective: To investigate, through a controlled and randomized clinical trial, the effectiveness of using Melissa officinalis in different concentrations in the treatment of children and adolescents with probable sleep bruxism.
- Conditions
- Sleep Bruxism, Adolescent, Children, Temporomandibular Joint Disorders
- Trial name
- NCT06214637
- Testing
- Melissa
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Spinal Cord Injuries, Spasticity, Muscle
Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury
Spasticity is muscle spasms, bouncing (clonus) or stiffness that can negatively impact the quality of life of people with spinal cord injury (SCI).
- Trial name
- NCT04130295
- Testing
- Wearable intensive nerve stimulator
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shepherd Center, Atlanta GA
TMJ Disorder, TMD
Prevalence of the Signs and Symptoms of TMD in Adolescents
the Prevalence of the Signs and Symptoms of Tempro-mandibular Joint Disorder in a sample of Egyptian adolescents
- Trial name
- NCT04543981
- Testing
- Diagnostic Criteria for Tempro-mandibular Disorders(DC/TMD)
- Where
- Egypt
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- Cairo University
Musculoskeletal Pain, Acute Pain
A Randomized Trial of NSAID Dosing Strategies
This study will compare the efficacy of two different non-steroidal anti-inflammatory drugs (NSAIDs) ketorolac and ibuprofen for people with acute moderate or severe musculoskeletal pain.
- Trial name
- NCT05239767
- Testing
- NSAID
- Where
- United States
- Volunteers
- 407 people
- Sponsor
- Montefiore Medical Center
Duchenne Muscular Dystrophy
Trial of Pamrevlumab (FG-3019), in Non-Ambulatory Participants With Duchenne Muscular Dystrophy (DMD)
This is a Phase 2, open-label, single arm trial of pamrevlumab (FG-3019) to estimate pamrevlumab's safety and efficacy in non-ambulatory participants with DMD.
- Trial name
- MISSION (NCT02606136)
- Testing
- Pamrevlumab
- Where
- 10 sites in United States
- Volunteers
- 21 people
- Sponsor
- Kyntra Bio
Chronic Fatigue Syndrome, Orthostatic Hypotension
Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
A subset of patients suffering from chronic fatigue syndrome exhibit symptoms of neurally mediated hypotension. While the underlying pathophysiology of chronic fatigue syndrome is not precisely understood, a dysfunction of the…
- Conditions
- Chronic Fatigue Syndrome, Orthostatic Hypotension, Neurally Mediated Hypotension, Neurogenic Orthostatic Hypotension
- Trial name
- CFS201 (NCT00977171)
- Testing
- Droxidopa
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Chelsea Therapeutics
Inflammatory Myopathy, Idiopathic, Dermatomyositis
Add-on Intravenous Immunoglobulins in Early Myositis
In patients with myositis early immunomodulation by intensive treatment ("hit-early/hit-hard" principle) may induce faster reduction of disease activity and prevent chronic disability.
- Conditions
- Inflammatory Myopathy, Idiopathic, Dermatomyositis, Antisynthetase Syndrome, Immune-Mediated Necrotizing Myopathy
- Trial name
- TIMEISMUSCLE (NCT05832034)
- Testing
- Immune Globulin Intravenous (Human)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Duchenne Muscular Dystrophy
Expanded Access Program for Idebenone in Participants With Duchenne Muscular Dystrophy (DMD)
The primary objective of this Expanded Access Program is to provide idebenone as a treatment for eligible participants with Duchenne Muscular Dystrophy before it is commercially available in the United States (U.S.) for the…
- Trial name
- NCT03433807
- Testing
- Idebenone
- Where
- 12 sites in United States
- Sponsor
- Santhera Pharmaceuticals
Muscle Weakness, Syndrome; Institutionalization
Effects and Costs of Respiratory Muscle Training in Institutionalized Elderly People
The global loss of muscle mass and strength associated with aging is a cause of functional impairment and disability, particularly in the older elderly (>80 years).
- Conditions
- Muscle Weakness, Syndrome; Institutionalization, Respiratory Morbidity, Cardiovascular Morbidity
- Trial name
- NCT01759992
- Testing
- Threshold® Inspiratory Muscle Trainer (treatment).
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- University of Valencia
Renal Function Disorder, Critical Illness
Transcutaneous Electrical Nerve Stimulation for Tissues Perfusion
The aim of this study is to determine the effect of transcutaneous electrical nerve stimulation in mechanically ventilated patients on the lower limb and renal tissue perfusion.
- Conditions
- Renal Function Disorder, Critical Illness, Critical Illness Myopathy
- Trial name
- NCT04069871
- Testing
- trans-cutaneous electrical nerve stimulation.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Lateral Epicondylitis
Effects of Photobiomodulation Therapy Combined With Static Magnetic Field in Patients With Lateral Epicondylitis
Lateral epicondylitis (LE) is one of the most frequently encountered lesions affecting the upper extremity and is the most common cause of elbow pain in adults.
- Trial name
- NCT04829734
- Testing
- Active PBMT-sMF
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Nove de Julho
Stroke
Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants
The purpose of this study is to investigate if acupuncture is more effective than sham treatment in reducing lower extremity spasticity, and improving gait speed in the chronic phase of stroke recovery.
- Trial name
- HHSCSTROKEAC (NCT02085642)
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Polymyalgia Rheumatica
Efficacy and Safety of Olokizumab in Patients With Polymyalgia Rheumatica (PROMISE)
The primary objective of the study is to evaluate the efficacy of olokizumab (OKZ) 64 mg administered subcutaneously every 2 weeks compared with placebo in participants with polymyalgia rheumatica (PMR).
- Trial name
- NCT07670546
- Testing
- Olokizumab
- Where
- 20 sites in Russia
- Volunteers
- 125 people
- Sponsor
- R-Pharm International, LLC
Facioscapulohumeral Muscular Dystrophy
Effects Antioxidants Supplementation on Muscular Function Patients Facioscapulohumeral Dystrophy (FSHD)
On the basis of published data and the investigators' results indicating that oxidative stress may contribute to the peripheral skeletal muscle dysfunction in patients with FSHD, the investigators propose a study to test whether…
- Trial name
- FSHD (NCT01596803)
- Testing
- Taking of blood, needle biopsy of the vastus lateralis muscle, Vit C Vit E Zn Se
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Montpellier
Polyostotic Fibrous Dysplasia
Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome
This study will investigate how a gene mutation (change in DNA) causes the abnormal bone in fibrous dysplasia-a condition in which areas of normal bone are replaced with a fibrous growth similar to a scar.
- Trial name
- NCT00001973
- Where
- United States
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
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