Clinical trials: MYOPATHY
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Mechanical Low Back Pain, Chronic Low Back Pain (CLBP)
Iliopsoas Counterstrain and Mechanical Chronic Low Back Pain
The aim of this study is to determine the effects of the Strain-Counterstrain (SCS) technique on alleviating sudden and mechanical chronic low back pain and resolving limited lumbar flexion and extension in individuals with…
- Trial name
- NCT06748859
- Testing
- Counterstrain technique, Exercise therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Marmara University
Myositis, Exercise
Resistance Exercise Reduces the Expression of Inflammation and Fibrosis Associated Genes in Autoimmune Myositis Patients
The aim of this study was to investigate the effects of physical exercise on gene expression in muscle biopsies from patients with chronic polymyositis or dermatomyositis
- Trial name
- NCT00519103
- Testing
- exercise
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Karolinska Institutet
Muscle Spasticity, Stroke
Measurements of Displacement Amplitude and Angular Velocities During Passive Extension of the Wrist and Hand Complex in Stroke Patients
The main objective of this monocentric prospective study is to evaluate the amplitudes and angular velocities of extension of the hand and wrist joints during passive mobilization by a physiotherapist in healthy subjects and…
- Trial name
- PHYSIOHAND (NCT04502927)
- Testing
- Passive extension mobilization of the hand and wrist joints
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Burnout Syndrome
Evaluating the Impact of Mindfulness Based Physical Therapy on Burnout Syndrome Among University Students.
The goal of this clinical trial is to evaluate whether a mindfulness-based physical therapy intervention can reduce burnout syndrome and improve musculoskeletal pain and quality of life among undergraduate Allied Health Sciences…
- Trial name
- NCT07456527
- Testing
- Standard Physical Therapy, Mindfulness Based Physical Therapy
- Where
- Pakistan
- Volunteers
- 55 people
- Sponsor
- University of Health Sciences Lahore
Muscular Diseases, Spinal Muscular Atrophy
Evaluation of Therapeutic Response in Spinal Muscular Atrophy Using Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI)
This study aims to refine the capability of Multispectral Optoacoustic Tomography (MSOT) and Magnet Resonance Imaging (MRI) to characterise the molecular composition of muscle tissue non-invasively and to evaluate the therapeutic…
- Trial name
- NCT04262570
- Testing
- Multispectral Optoacoustic Tomography (MSOT) and Magnetic Resonance Imaging (MRI)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cerebral Palsy, Whole Body Vibration
Effects of WBV in Children With Hemiparetic CP
The aim of this study was to investigate short and long-term effects of Whole Body Vibration therapy on spasticity and motor performance in children with hemiparetic cerebral palsy in addition to conventional physiotherapy.
- Conditions
- Cerebral Palsy, Whole Body Vibration, Spastic Hemiplegia, Motor Performance
- Trial name
- NCT04528966
- Testing
- Whole-Body Vibration, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Pamukkale University
Muscular Dystrophies
Pro-inflammatory Cytokines in Facioscapulohumeral Muscular Dystrophy (CYTOKINE-FSH)
The facial-glenohumeral muscular dystrophy type 1 (DMFSH1) is characterized by a selective and asymmetrical involvement of the facial muscles, the shoulder girdle and the anterolateral lodge legs.
- Trial name
- CYTOKINE-FSH (NCT04694456)
- Testing
- cytokines dosage, test of walk, Manual muscular test
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lateral Epicondylitis (Tennis Elbow)
Dry Needling vs ESWT in Lateral Epicondylitis
This randomized single-blind controlled trial aims to compare the effectiveness of ultrasound-guided dry needling and extracorporeal shock wave therapy in patients with lateral epicondylitis.
- Trial name
- NCT07550322
- Testing
- Ultrasound-guided dry needling, Extracorporeal Shock Wave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Interstitial Pneumonia Associated With Polymyositis/Dermatomyositis
A Survey for Long-term Use of Prograf Capsules in Patient With Interstitial Pneumonia
This study is to evaluate the safety and the efficacy of Prograf in patients with interstitial pneumonia associated with polymyositis / dermatomyositis in acute clinical setting.
- Trial name
- NCT02159651
- Testing
- tacrolimus
- Where
- 8 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Astellas Pharma Inc
Musculoskeletal Pain
A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers
This phase 1 study is to evaluate the safety and pharmacokinetic drug interactions of DHP2306R1 and DHP2306R2 when administered alone and in combination in healthy conditions.
- Trial name
- NCT06395155
- Testing
- DHP2306R1, DHP2306R2
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Daehwa Pharmaceutical Co., Ltd.
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Paraplegia, Spinal Cord Injuries
Natural History of Shoulder Pathology in Manual Wheelchair Users
Over 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level…
- Conditions
- Paraplegia, Spinal Cord Injuries, Shoulder Pain, Tendinopathy
- Trial name
- NHSSI (NCT02600910)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Trigger Point Pain, Myofascial
Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty
This study will evaluate the ability of trigger point injections completed immediately following a total knee arthroplasty decrease pain scores and opioid use compared to sham injections.
- Trial name
- NCT06955923
- Testing
- Trigger point injection (lidocaine)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David Grant U.S. Air Force Medical Center
Myalgia, Myofascial Pain
Masseter Myofascial Pain Relief Following an Intra-muscular Injection With Botulinum Toxin Type A.
Investigating the effect of a single intramuscular injection with botulinum toxin (BTX) compared to NaCl in patients with jaw muscle myalgia.
- Trial name
- NCT04426123
- Testing
- Botulinum toxin type A, saline solution
- Volunteers
- 48 people
- Sponsor
- Region Örebro County
Fibromyalgia
Evaluate the Efficacy and Safety of NYX-2925 in Subjects With Fibromyalgia
The primary objective is to determine whether daily dosing with NYX-2925 changes markers of central pain processing in subjects with fibromyalgia by evaluating changes in evoked pain, and visual stimulation, functional magnetic…
- Trial name
- NCT03249103
- Testing
- NYX-2925
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Aptinyx
Stroke Sequelae, Chronic Pain
Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic Diseases
Background: Chronic non-nociceptive or nociplastic pain and neurological sequelae following stroke are associated with substantial functional impairment and reduced quality of life.
- Conditions
- Stroke Sequelae, Chronic Pain, Fibromyalgia, Long COVID19
- Trial name
- FATMAGPAIN (NCT07888673)
- Testing
- Transcraneal Magnetic Stimulation (rTMS)
- Where
- 2 sites in Spain
- Volunteers
- 47 people
- Sponsor
- Hospital Donostia
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Polymyalgia Rheumatica (PMR)
Justification And Evaluation of Baricitinib Plus Corticosteroids Versus corticosteroiDs Alone in pOlymyalgia RhEumatica
Polymyalgia rheumatic (PMR) is an inflammatory rheumatic disease affecting the elderly. The diagnosis is based on established ACR/EULAR classification criteria.
- Trial name
- JADORE-BARI (NCT07279688)
- Testing
- Baricitinib 4 MG Oral Tablet, Baricitinib 2 MG Oral Tablet
- Where
- 23 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Brest
SLE (Systemic Lupus), Lupus Erythematosus, Systemic
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
This is a single-arm, open-label, multicenter, ascending dose Phase 1 study evaluating the safety and preliminary efficacy of CTX112 in adult subjects with refractory autoimmune diseases, including active systemic lupus…
- Conditions
- SLE (Systemic Lupus), Lupus Erythematosus, Systemic, Lupus Nephritis, Systemic Sclerosis
- Trial name
- NCT06925542
- Testing
- CTX112
- Where
- 17 sites in United States, Germany and 1 more
- Volunteers
- 80 people
- Sponsor
- CRISPR Therapeutics
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