Clinical trials: MYOPATHY
Duchenne Muscular Dystrophy (DMD)
Bone Health in Adults With Duchenne Muscular Dystrophy: A Survey on Osteoporosis, Fractures and Treatment.
Background and Rationale Duchenne muscular dystrophy (DMD) is a genetic disorder caused by mutations in the dystrophin gene, resulting in progressive muscle weakness and multiple complications, including respiratory and cardiac…
- Trial name
- GUP23005 (NCT07890883)
- Where
- 15 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Giannina Gaslini
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome (SS)
A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases
This is an open-label, dose escalation study in patients with relapsed and refractory autoimmune diseases. Study drug, TI-0032-III injection, is composed of lipid nanoparticles (LNPs) targeting T cells that encapsulate circular…
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome (SS), Systemic Sclerosis (SSc), Inflammatory Myopathy
- Trial name
- in vivo CAR-T (NCT07413341)
- Testing
- TI-0032-III injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Therorna
Fibromyalgia, Fatigue
Functional Capacity Determinants in Fibromyalgia
Fibromyalgia is a chronic pain disorder characterized by widespread pain and multiple systemic symptoms that negatively affect functional capacity.
- Trial name
- NCT07318441
- Testing
- Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Democracy University
Temporomandibular Disorder, Manual Therapy
Effects on Pain and Function of Orthopedic Manual Therapy in Patients With Painful Disc Displacement With Reduction
The objective of this study was to compare the short- and medium-term effects in pain and temporomandibular joint (TMJ) and function of implementing a manual therapy (MT) intervention treatment combined with a therapeutic…
- Trial name
- NCT05728905
- Testing
- Therapeutic exercise, Orthopedic manual therapy
- Where
- Mexico
- Volunteers
- 75 people
- Sponsor
- Fisioterapia Manual Ortopedica
Neuromuscular Disease
Phenotype/Genotype Correlations in Neuromuscular Disorders
The Neuromuscular Diseases Section (NDS) is conducting research on certain inherited myopathies and neuropathies, disorders that lead to disability and sometimes death.
- Trial name
- NCT00017745
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dermatomyositis, Idiopathic Inflammatory Myopathies
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis
Background: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis.
- Trial name
- NCT03267277
- Testing
- Sodium Thiosulfate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Plantar Fibromatosis, Ledderhose Disease
Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease)
This study will assess the efficacy, safety, and tolerability of EN3835 compared to placebo in the treatment of PFI (also known as Ledderhose disease).
- Trial name
- STRIDE (NCT06151197)
- Testing
- EN3835
- Where
- 66 sites in United States, Puerto Rico
- Volunteers
- 436 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Pain, Acute
Exploration of Gait Biomechanics and Muscle Pain of the Lower Extremity
This interventional study aims to test gait biomechanics in healthy individuals with and without experimental muscle pain in the lower extremities.
- Trial name
- NCT06411197
- Testing
- Hypertonic saline injection, Isotonic saline injection
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Kristian Kjær Petersen
Polymyalgia Rheumatica, Giant Cell Arteritis
Polymyalgia Rheumatica and Giant Cell Arteritis
The purpose of this study is to delineate the association of the 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) detected vasculitis pattern of the large vessels (PET positivity) and the…
- Trial name
- NCT02985424
- Testing
- 18F-FDG PET/CT
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Svendborg Hospital
Chronic Fatigue Syndrome
A Rehabilitation Program for Adolescents With Chronic Fatigue Syndrome
The aim of the programme is to develop a treatment model for adolescents with Chronic Fatigue Syndrome. The program consists of 4 elements lasting for 12 months, psychoeducation reflecting the current knowledge about the disease…
- Trial name
- NCT01806246
- Testing
- integrative rehabilitation program
- Where
- Norway
- Volunteers
- 13 people
- Sponsor
- St. Olavs Hospital
Tendinopathy, Shoulder Impingement Syndrome
The Effect of an Evidence-based Physiotherapy Regimen for Patients With Rotator Cuff Tendinopathy
Primary aim of this study is to investigate wether an evidence-based physiotherapy regimen is more effective than standard care in patients referred for arthroscopic surgery of the shoulder.
- Conditions
- Tendinopathy, Shoulder Impingement Syndrome, Shoulder Pain, Subacromial Impingement
- Trial name
- NCT02304003
- Testing
- Structured Physiotherapy Regimen, Standard Care
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Bergen University College
Myotonic Dystrophy Type 1
Metabolomic Biomarkers of Myotonic Dystrophy
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Trial name
- NCT07912983
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dermatomyositis, Myositis
A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis
This study will evaluate the safety and efficacy of empasiprubart compared with placebo in adult participants with dermatomyositis (DM). The study duration will be approximately 92 weeks for all participants.
- Trial name
- empacific (NCT06284954)
- Testing
- Empasiprubart IV
- Where
- 28 sites in United States, Georgia and 5 more
- Volunteers
- 3 people
- Sponsor
- argenx
Fibromyalgia, Diffuse Myofascial Pain Syndrome
Trial of Acupuncture in the Treatment of Fibromyalgia
Fibromyalgia is a medical condition characterized by musculoskeletal pain, fatigue, sleep disturbances and depression. It affects population at a socioeconomically active age and represents a burden for the patients and the…
- Conditions
- Fibromyalgia, Diffuse Myofascial Pain Syndrome, Fibromyalgia-Fibromyositis Syndrome, Fibromyositis-Fibromyalgia Syndrome
- Trial name
- NCT01189994
- Testing
- Acupuncture, Orientation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Santa Casa da Misericordia do Rio de Janeiro Hospital
Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies
A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases
The purpose of this study is to assess the safety and efficacy of CD19 UCAR-T cell therapy in Subjects with autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Sjögren's Syndrome
- Trial name
- ET-902-AID01 (NCT07212322)
- Testing
- CD19 UCAR-T cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Fibromyalgia
Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia
This is a 24-week, randomized, double-blind, placebo-controlled, trial to evaluate the safety, tolerability and efficacy of an orally administered growth hormone stimulating drug, (code named MK-0677) in the treatment of female…
- Trial name
- NCT00116129
- Testing
- Ibutamoren Mesylate (MK-0677)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Bennett, Robert, M.D.
Fibromyalgia
Effect of Transcranial Direct Current Stimulation Associated With Aerobic Exercise Training for Patients With Fibromyalgia
This study consists of a randomized, double-blind, clinical trial with two months' duration of follow-up. The variable used was the VAS for pain, considering the values of any difference between the data before and after…
- Trial name
- NCT02358902
- Testing
- tDCS, active intervention of aerobic exercise
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Temporomandibular Joint Dysfunction
Telerehabilitation Dual-Task Training in Temporomandibular Joint Dysfunction
This randomized controlled trial will be conducted among 18-25-year-old participants who present with temporomandibular joint dysfunction symptoms, including pain, limited range of motion, and joint crepitation.
- Trial name
- NCT07556510
- Testing
- Standard Physiotherapy Program, Dual-Task Training
- Volunteers
- 30 people
- Sponsor
- Ege University
TMD, Temporomandibular Disorders (TMD)
Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints
This randomized controlled research aimed to analyse the occlusion and assist the enamel wear before and after using of the stabilization splints produced by the conventional methods with the fully digitally fabricated…
- Trial name
- NCT06781320
- Testing
- stabilization splint
- Volunteers
- 20 people
- Sponsor
- Minia University
Injection Site, Fibromyalgia
Trigger Point Injection in Patients With Myofascial Pain Syndrome
This study aims to compare the effectiveness of blinded versus ultrasound-guided trigger point injections into the trapezius muscle in patients with FMS. Seventy-five patients with FMS will participate in this study.
- Trial name
- NCT06555523
- Testing
- Ultrasound guided injection, Blinded injection
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Firat University
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