Clinical trials: MYOPATHY
Facio-Scapulo-Humeral Dystrophy
Computerized Facial Recognition for Automated Diagnosis of the Facio-Scapulo-Humeral Muscular Dystrophy (FSMHD)
The clinical diagnosis of Facio-Scapulo-Humeral Muscular Dystrophy (FSHMD) requires the movement of patients to a medical centre and a lengthy examination involving medical personnel, and may be underestimated in the most…
- Trial name
- CV4DIAGNOSIS (NCT04377217)
- Testing
- Video recording
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Muscular Weakness, Sexual Behavior
Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life
Decreased muscle mass (sarcopenia) and strength (dynapenia) are common during aging, with a rate of muscle mass loss that is approximately 6% per decade between 30 and 70 years of age.
- Conditions
- Muscular Weakness, Sexual Behavior, Quality of Life
- Trial name
- NCT03457740
- Testing
- Formula 1, Formula 2
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Inclusion Body Myositis, Sporadic
Ruxolitinib Treatment in Inclusion Body Myositis
Refer to the "Detailed Description" section.
- Trial name
- BIGTIM (NCT06536166)
- Testing
- Ruxolitinib
- Where
- 21 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Muscle Spasticity
Upper-limb Active Function and Botulinum Toxin A
This study in an observational, prospective and longitudinal study. The aim of the study is to evaluate the effect of botulinum toxin type A (BTX) injections into the elbow flexors on the reduction of spastic co-contractions…
- Conditions
- Stroke, Muscle Spasticity, Upper Extremity Paralysis
- Trial name
- ULAFBoT-Stroke (NCT03783572)
- Testing
- Clinical evaluation, Clinical evaluation and Instrumental evaluation
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fibromyalgia
FIbromyalgia anD GenetIcs Subgroups (FIDGIS)
Fibromyalgia syndrome (FS) is characterized by widespread pain and affect 0.5 to 5 % of the general population, with a higher prevalence in women.
- Trial name
- FIDGIS (NCT04624581)
- Testing
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Hematologic Malignancy, Muscle Weakness
Effects of NMES and Exercise in Hematological Cancer
Physical activity levels of adult hematologic cancer patients are deficient. The resulting physical inactivity causes fatigue, muscle loss, and deterioration in physical performance values.
- Trial name
- NCT04755465
- Testing
- Neuromuscular Electrical Stimulation, Structured Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Acibadem University
Dermatomyositis, Polymyositis
Study of M5049 in DM and PM Participants (NEPTUNIA)
The purpose of this study is to evaluate the efficacy and safety of orally administered M5049 in idiopathic inflammatory myopathies, specifically dermatomyositis (DM) and polymyositis (PM) participants for 24 weeks.
- Trial name
- NCT05650567
- Testing
- M5049 dose
- Where
- 31 sites in United States, Czechia and 5 more
- Volunteers
- 20 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Chronic Fatigue Syndrome
Valganciclovir (Valcyte) for Chronic Fatigue Syndrome Patients Who Have Elevated Antibody Titers Against Human Herpes Virus 6 (HHV-6)and Epstein-Barr Virus (EBV)
The purpose of this study determine whether the drug valganciclovir has a significant and real benefit on the central core of symptoms experienced by patients who have high titers to EBV and HHV-6 and are experiencing…
- Trial name
- NCT00478465
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Spasticity
MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity
This study is a randomized, double blind, multi-center, active drug controlled, phase III clinical trial to compare the efficacy and safety of MEDITOXIN® versus BOTOX® in treatment of post stroke upper limb(wrist, finger, thumb)…
- Trial name
- NCT01313767
- Testing
- Botulinum toxin type A
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Medy-Tox
Lateral Epicondylitis
Multimodal Rehabilitation Approach in Patients of Lateral Epicondylitis
Literature is scarce for high quality evidence regarding multimodal rehabilitation in lateral epicondylitis. By making comparisons with the conventional treatment of patients with lateral epicondylitis, the current study aims to…
- Trial name
- NCT06686732
- Testing
- Multimodal physiotherapy, Conventional physiotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Fibromyalgia
A Study of the Efficacy and Safety of Pregabalin for the Treatment of Fibromyalgia
The purpose of this study is to evaluate the efficacy and safety of pregabalin versus placebo for the symptomatic relief of pain associated with fibromyalgia.
- Trial name
- NCT00645398
- Testing
- Pregabalin
- Where
- 102 sites in United States
- Volunteers
- 751 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Limb Girdle Muscular Dystrophy
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants
A large cohort of MRI scans from patients with pathogenic variants in the anoctamin 5 gene will be collected through an international collaboration to better describe muscle involvement.
- Trial name
- ANO5 MRI (NCT05102799)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Treatment Outcome, Muscle Dystonia
Quantifying Muscle Tone in Patients With Brain Injury - a Feasibility Study
This project will determine the feasibility and validity of measuring elbow muscle flexor stiffness in a population of patients with sub-acute severe acquired brain injury using two measurement methods, the portable spasticity…
- Conditions
- Treatment Outcome, Muscle Dystonia, Spasticity, Muscle, Muscle Tightness
- Trial name
- NCT04207632
- Testing
- Botulinum toxin type A injection
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dupuytren Contracture, Collagen Shrinkage
Registry of Patient With M. Dupuytren and Validation of the Brief MHQ
The purpose of this study is the validation of the Brief Michigan Hand Questionnaire by patient with Morbus Dupuytren and to build up a register.
- Conditions
- Dupuytren Contracture, Collagen Shrinkage, CRF
- Trial name
- NCT01876498
- Testing
- Xiaflex surgery
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Schulthess Klinik
Fibromyalgia
Impact of the Restriction of Sources of Gluten in Fibromyalgia Patients
The aim of this study is to evaluate the impact of gluten-free diets on symptoms and inflammatory markers in individuals with previous diagnosis of fibromyalgia (FM), as well as to identify the presence of non-celiac gluten…
- Trial name
- NCT03129906
- Testing
- Gluten, Rice protein
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Federal University of Minas Gerais
Fibromyalgia
Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia
The goal of this clinical trial is to evaluate a new noninvasive brain stimulation intervention for fibromyalgia and to determine its effectiveness in reducing pain.
- Trial name
- NCT07226648
- Testing
- Focused Ultrasound
- Where
- 8 sites in United States
- Volunteers
- 180 people
- Sponsor
- SPIRE Therapeutics Inc.
Temporomandibular Disorders (TMD), Nociplastic Pain
Effects of Aerobic and Strength Exercice on Nociplastic Pain in Temporomandibular Disorders
Chronic temporomandibular disorders are common in the general population. Nociplastic pain seems to be present in this pathology, with an hypersensitivity to touch, pressure and movement observed in both local and remote areas…
- Conditions
- Temporomandibular Disorders (TMD), Nociplastic Pain, Aerobic Exercise, Strengthening Exercises
- Trial name
- NCT06584526
- Testing
- Physical Therapy, Physical Therapy and Aerobic Exercise, Physical Therapy and Strength Exercise
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Universitat Internacional de Catalunya
Cerebral Palsy, Spasticity
Dutch National ITB Study in Children With Cerebral Palsy
The objective of this study is to determine the efficacy and safety of treatment with intrathecal baclofen for severe spasticity in children with cerebral palsy.
- Trial name
- NCT00367068
- Testing
- baclofen, intrathecal, infusion pump for intrathecal baclofen, Synchromed, Medtronic
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Maastricht University
Systemic Sclerosis, Other Connective Tissue Disease
Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis
Systemic SClerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and/or fibrosis.
- Conditions
- Systemic Sclerosis, Other Connective Tissue Disease, Systemic Lupus Erythematosus, Dermatomyositis
- Trial name
- NETOSE (NCT06462768)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
CureDuchenne Link®: A Resource for Research
CureDuchenne link is a data hub comprised of integrated biospecimens, clinical data, and self- and/or caregiver-reported information from participants.
- Trial name
- CDLink (NCT04972604)
- Where
- 10 sites in United States
- Volunteers
- 240 people
- Sponsor
- CureDuchenne
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