Clinical trials: MYOPATHY, open to volunteers
Liver Cirrhosis, Muscle Cramps
Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity.
- Trial name
- NCT02423395
- Testing
- orphenadrine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Cerebral Palsy (CP), Musculoskeletal Pain
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy
This randomized, double-blind, sham-controlled clinical trial will evaluate the safety and efficacy of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with cerebral palsy (CP)…
- Trial name
- NCT07585292
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Exercise Recovery, Physical Performance Parameters
Effects of Pork Protein on Recovery Following Simulated Fireground Activity
The goal of this clinical trial is to learn whether consuming pork-based protein before and after physically demanding simulated firefighting activities can improve recovery, physical performance, and cognitive performance in…
- Conditions
- Exercise Recovery, Physical Performance Parameters, Muscle Damage, Cognition
- Trial name
- PORK-FIRE (NCT07819565)
- Testing
- Pork-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals, Carbohydrate-Focused Lower-Protein Ready-to-Eat Meals
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
IBM, Inclusion Body Myositis
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
This study will evaluate whether neuromuscular ultrasound and MRI can be used as imaging markers of bulbar involvement and swallowing dysfunction in individuals with inclusion body myositis (IBM).
- Conditions
- IBM, Inclusion Body Myositis, Myopathy, Myositis
- Trial name
- NCT07823101
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Duchenne Muscular Dystrophy
Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy
This is a randomised, double-blind, placebo-controlled, multicentre study to evaluate the efficacy, safety, and tolerability of givinostat in non-ambulant male paediatric (aged 9 to <18 years) patients with DMD.
- Trial name
- ULYSSES (NCT05933057)
- Testing
- Givinostat
- Where
- 29 sites in Belgium, Canada and 10 more
- Volunteers
- 138 people
- Sponsor
- Italfarmaco
Muscle Weakness, Low Muscle Mass
Muscle Aging Phenotypes in Childhood Cancer Survivors
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality.
- Conditions
- Muscle Weakness, Low Muscle Mass, Sarcopenia
- Trial name
- NCT07531498
- Testing
- Multimodal Muscle Imaging and Functional Assessment, Multimodal Muscle Imaging and Neuromuscular Assessment, Comprehensive Muscle Phenotyping
- Where
- United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Munich ME/CFS Cohort Study
The Munich cohort study MUC-CFS aims at the characterization and long-term follow-up of myalgic encephalitis/chronic fatigue syndrome (ME/CFS) in young people aged up to 25 years, as well as at the identification of…
- Trial name
- MUC-CFS (NCT06005246)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Myotonic Dystrophy Type 1 (DM1), DM1
Remote Assessments and Genetic Determinants of Myotonic Dystrophy
The goal of this observational study, conducted in participants' homes and requiring no travel to a study site, is to better understand disease variability in people with myotonic dystrophy type 1 (DM1) and to identify effective…
- Trial name
- REACH-DM (NCT07505342)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Rochester
Sarcopenia, Asthma
Impact of Sarcopenia on Dyspnea in Patients With Asthma
Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown.
- Conditions
- Sarcopenia, Asthma, Dyspnea, Dyspnea; Asthmatic
- Trial name
- MUDYSA (NCT06870890)
- Testing
- muscle evaluation, Dosage, Cardiopulmonary exercise test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Oculopharyngeal Muscular Dystrophy
Oral Health, Saliva Viscosity and Composition in Oculo-Pharyngeal Muscular Dystrophy (OPMD)
The goal of this observational study is to explore whether oral health and saliva viscosity and composition in Oculopharyngeal Muscular Dystrophy (OPMD) is different from control subjects.
- Trial name
- NCT07118280
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Fibromyalgia, Pregabalin
The Efficacy and Safety of Pregabalin Combined With Dexmedetomidine in Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, and emotional disorders. Its onset is related to factors such as central sensitization and imbalance of neurotransmitters.
- Conditions
- Fibromyalgia, Pregabalin, Dexmedetomidine
- Trial name
- NCT07230197
- Testing
- Pregabalin, Pregabalin with dexmedetomidine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Back Pain, Low Back Pain
Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica
The purpose of this study is to identify the prevalence of neck and low back pain in medical students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and…
- Conditions
- Back Pain, Low Back Pain, Neck Pain, Neck Pain Musculoskeletal
- Trial name
- NCT03707288
- Testing
- Clinical Control Group (Group A), Spine Exercise Program (Group B)
- Where
- 2 sites in Jamaica
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Fibromyalgia, Cognitive Dysfunction
Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia
The aim of the study is to investigate the relationship between central sensitization parameters and cognitive dysfunction in patients with fibromyalgia.The main questions it aims to answer are: Do central sensitization symptoms…
- Conditions
- Fibromyalgia, Cognitive Dysfunction, Central Sensitisation
- Trial name
- NCT06948903
- Testing
- Central Sensitization Inventory, The Montreal Cognitive Assessment, Cognitive Symptom Severity Scale-Extended
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy
Critical Illness Weakness Outside the Intensive Care Unit.
When people become seriously ill, their bodies can be affected in many ways beyond the original disease. One well-known complication in patients treated in intensive care units (ICUs) is the development of severe muscle weakness…
- Conditions
- Critical Illness Polyneuromyopathy, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- CRI-WEAK-OUT (NCT07478367)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Clinico Humanitas
Intensive Care Unit Syndrome, Intensive Care Neuropathy
Recovery From ICUAW Following Severe Respiratory and Cardiac Failure
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO).
- Conditions
- Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy, Acute Respiratory Distress Syndrome
- Trial name
- CLEVERER (NCT03753412)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Fibromyalgia
Thoracolumbar Fascia Thickness in Women With Fibromyalgia
This prospective cross-sectional observational study aims to compare thoracolumbar fascia thickness between women with fibromyalgia and healthy female controls using ultrasonography.
- Trial name
- FMS (NCT07839065)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
To Evaluate the Efficacy and Safety of Selected TCM Elbow Manipulation in Treating, Lateral Epicondylitis
Efficacy and Safety of Selected Traditional Chinese Medicine Elbow Manipulation Versus Mill's Manipulation as Control for Lateral Epicondylitis
Background: Lateral epicondylitis (LE), also referred to as lateral elbow tendinopathy and tennis elbow, is commonly seen clinically as an orthopedic disease.
- Trial name
- NCT07843771
- Testing
- Selected Traditional Chinese Medicine manipulation, Mill's Manipulation
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Giant Cell Arteritis, Polymyalgia Rheumatica
Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA).
- Trial name
- NCT04102930
- Where
- 76 sites in United Kingdom
- Volunteers
- 4,500 people
- Sponsor
- University of Leeds
Psychoeducation, Parents
Psychoeducation Program for Parents of Children with Duchenne Muscular Dystrophy
Having and caring for a child with disabilities brings emotional, social and economic difficulties for many families. Families may experience many physiological and psychological problems due to the stress and anxiety they…
- Conditions
- Psychoeducation, Parents, Psychological Wellness, Duchenne Muscular Dystrophy
- Trial name
- NCT06412328
- Testing
- Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Lokman Hekim University
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