Clinical trials: Macula Hole
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Intraocular Pressure,, Postoperative Complications
Primary Vitrectomy for the Treatment of Retinal Detachment in Highly Myopic
Purpose: To assess the functional and anatomical outcome of primary vitrectomy without scleral buckling for rhegmatogenous retinal detachment (RRD) in highly myopic eyes with axial length over 30 mm.
- Trial name
- NCT01480505
- Testing
- Pars plana vitrectomy with gas tamponade
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Hole, Myopia
Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent
Macular hole (MH) is a common condition that affects approximately 1.6/1000 elderly Chinese population. The prevalence is expected to be even higher in individuals with high myopia (HM), an established risk factor for MH.
- Trial name
- NCT07129798
- Testing
- ILM flap with no endotamponade technique
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Macular Holes, Retina Detachment
Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
The aim of this study was to determine whether inverted ILM peeling technique could contribute to high reattachment and closure rates after vitrectomy in patients with myopic macular hole retinal detachment (MHRD) in comparison…
- Trial name
- NCT04011007
- Testing
- vitrectomy with or without inverted ILM flap technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Macular Holes
Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery.
- Trial name
- NCT01687829
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yifan Feng
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Macular Hole Surgery
Autologous Tenon's Capsule Graft for Refractory Macular Holes
This prospective interventional study evaluates the anatomical and functional outcomes of autologous Tenon's capsule grafting in patients with refractory full-thickness macular holes.
- Trial name
- ATCG-RMH (NCT07318961)
- Testing
- Autologous Tenon's Capsule Graft Placement
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Idiopathic Macular Hole, Effective Prone Time
Analysis of Novel Positioning Sensor-assisted Postoperative Position Correction and Effective Prone Time Recorded in Patients With Different Prone Times After Macular Hole Surgery
Idiopathic macular hole (IMH) is a fundus disease without clear etiology, most often seen in healthy women over 50 years of age, and is often associated with ocular manifestations such as loss of central vision and visual…
- Trial name
- NCT05757349
- Testing
- Face-down position time 1-day, Face-down position time 3-day
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin Medical University Eye Hospital
Macular Holes
Duration of Face Down Positioning for Full-Thickness Macular Hole Repair
A full-thickness macular hole is when there is a small gap that opens in the center part of the retina (the light-sensitive layer of tissue in the back of the eye).
- Trial name
- NCT06000111
- Testing
- 3 Days of face-down positioning, 7 Days of face-down positioning
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Full Thickness Macular Hole
Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)
The purpose of this study is to determine the effect of postoperative posturing on the outcome of macular hole surgery. Current practice is divided; some individuals are advised to posture face-down for 10 days and others are…
- Trial name
- NCT01020760
- Testing
- Face down posture
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Retinal Detachment, Full Thickness Macular Hole
Inflammasomes in Cell Death in FTMH, ERM, and RRD
Prospective study evaluating the role of inflammasomes in cell death in retinal detachment, full thickness macular hole, and epiretinal membrane.
- Conditions
- Retinal Detachment, Full Thickness Macular Hole, Epiretinal Membrane
- Trial name
- NCT03332758
- Testing
- Pars plana vitrectomy, External drainage
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Allen C. Ho, MD
Macular Hole, Visual Acuity
Combined Versus Successive Macular Hole and Cataract Surgery
The purpose of this study is to compare functional and anatomical results of a combined surgery and two time surgery for macular hole and cataract extraction in one hundred and twenty patients (120 eyes) with idiopathic Macular…
- Trial name
- NCT01069029
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ophthalmopathy
Autologous Blood for Full-thickness Macular Hole
Autologous blood for primary and recurrent holes
- Trial name
- NCT05494229
- Testing
- Pars-plana vitrectomy
- Where
- Iraq
- Volunteers
- 5 people
- Sponsor
- Omer Othman Abdullah
Macular Hole, RPE Detachment
Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies
The purpose of this study is to compare the newly released Spectral OCT/SLO (OTI, Toronto, Canada) with the Zeiss Stratus OCT (Carl-Zeiss Meditec, Dublin, CA) with regards to the quality of the images obtained as well as the ease…
- Conditions
- Macular Hole, RPE Detachment, Epiretinal Membrane, Posterior Vitreous Detachment
- Trial name
- NCT00408720
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The New York Eye & Ear Infirmary
Macular Holes, Macular Hole Surgery
Autologous Tenon's Capsule Autograft for Large and Recurrent Full-Thickness Macular Holes
This prospective interventional clinical trial aims to evaluate the anatomical and functional outcomes of autologous Tenon's capsule autograft in the surgical management of large and recurrent full-thickness macular holes.
- Trial name
- ATCG-MH (NCT07760259)
- Testing
- Autologous Tenon's Capsule Autograft
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Macular Hole
Air Tamponade in Macular Hole Surgery
Macular hole is a hole formation which takes place in the center of the retina. Such a hole needs surgical steps in order to close. Closure of the macular hole will lead to a substantially improvement of vision in most cases.
- Trial name
- NCT01680068
- Testing
- Pars plana vitrectomy and postoperative air tamponade
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Helse Stavanger HF
Diabetic Retinopathy, Retinal Vein Occlusion
Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph
Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma.
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Retinal Artery Occlusion, Central Serous Chorioretinopathy
- Trial name
- NCT04723160
- Testing
- Software assisted imaging diagnosis
- Where
- 5 sites in China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Visionary Intelligence Ltd.