Clinical trials: Macular Hole, open to volunteers
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Macular Hole Surgery
Autologous Tenon's Capsule Graft for Refractory Macular Holes
This prospective interventional study evaluates the anatomical and functional outcomes of autologous Tenon's capsule grafting in patients with refractory full-thickness macular holes.
- Trial name
- ATCG-RMH (NCT07318961)
- Testing
- Autologous Tenon's Capsule Graft Placement
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Cataract, Vitreous Hemorrhage
Surgical Procedure Efficiency Evaluation stuDy
The purpose of this real-world evidence study is to compare surgical procedure times for UNITY® VCS and CONSTELLATION® Vision System.
- Conditions
- Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker
- Trial name
- NCT07228091
- Testing
- UNITY VCS, CONSTELLATION
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Alcon Research
Macular Hole Surgery, ILM Peeling
Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)
The aim of this study is to compare the functional visual outcomes, anatomical closure rate and macular perfusion changes assessed by OCT and OCTA after surgical repair of macular hole using Tenon capsule graft versus ILM flap.
- Conditions
- Macular Hole Surgery, ILM Peeling, Tenon Capsule, ILM Flap
- Trial name
- NCT07633457
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Macular Holes
Full-Thickness Macular Hole Surgery: A Comparison of Ten Techniques
This study compares ten modern vitreoretinal surgical techniques for full-thickness macular hole repair. Participants will be randomly assigned to one of the surgical approaches during pars plana vitrectomy, using stratified…
- Trial name
- FTMH-10 (NCT07606404)
- Testing
- Pars Plana Vitrectomy (PPV)-Based Macular Hole Surgery, Autologous Platelet-Rich Plasma (PRP), Human Amniotic Membrane (hAM) Graft
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Eye Research Institute
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Macular Hole, Macular Hole Surgery
No Endotamponade for Macular Hole Repair: the NEMAR Study
Full-thickness macular hole (MH) is a common sight threatening macular condition with a prevalence of 3.3 per 1000 individuals. Prompt surgical repair of MH is imperative in preventing irreversible vision loss from MH as the…
- Trial name
- NEMAR (NCT06908824)
- Testing
- Conventional surgery, ILM flap with no gas tamponade
- Where
- 3 sites in Hong Kong, Poland and 1 more
- Volunteers
- 180 people
- Sponsor
- Chinese University of Hong Kong
Idiopathic Macular Hole, Macular Hole
Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes
The goal of this clinical trial is to evaluate the visual and anatomical outcomes of large (410-1000 μm) full-thickness macular holes repair surgery using perfluoropropane (15% C3F8), sulfur hexafluoride (20% SF6) gas tamponade.
- Conditions
- Idiopathic Macular Hole, Macular Hole, Macular Holes, Full Thickness Macular Hole
- Trial name
- NCT06927544
- Testing
- Pars plana vitrectomy
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Macular Holes
Duration of Face Down Positioning for Full-Thickness Macular Hole Repair
A full-thickness macular hole is when there is a small gap that opens in the center part of the retina (the light-sensitive layer of tissue in the back of the eye).
- Trial name
- NCT06000111
- Testing
- 3 Days of face-down positioning, 7 Days of face-down positioning
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Macular Hole, Macular Hole Surgery
Minimal Vitrectomy and ILM Flap with Sodium Hyaluronate Gel for MH
The purpose of this clinical trial is to compare the prognostic validity of two different surgical approaches: minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap…
- Conditions
- Macular Hole, Macular Hole Surgery, Idiopathic Macular Hole, Macular Hole of Left Eye (Disorder)
- Trial name
- ILM MH (NCT06685328)
- Testing
- minimal posterior pole vitrectomy combined with a sodium hyaluronate gel-covered internal limiting membrane(ILM) flap with balanced saline filling and postoperative supine position, Conventional vitrectomy combined with inner limiting membrane flap flip coverage with sterile air filling and postoperative prone position
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Jie Zhong
Macular Holes
Small Macular Holes Treated With Air
Non-inferiority trial comparing intraocular air and gas tamponade for closure of macular holes.
- Trial name
- NCT06211907
- Testing
- Postoperative intraocular tamponade
- Where
- 7 sites in Greece, Norway and 1 more
- Volunteers
- 132 people
- Sponsor
- Helse Stavanger HF
Full Thickness Macular Hole
Full Thickness Macular Hole; Should it be Handled Subacutely?
Full thickness macular hole, FTMH, is a retinal disease involving the fovea that cause central vision loss, metamorphopsia and central scotoma.
- Trial name
- NCT05828251
- Testing
- Vitrectomy (Sequential phakoemulsification and vitrectomy), Combined phako-vitrectomy, Phako (Sequential phakoemulsification and vitrectomy)
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Macular Holes
PEELED INTERNAL LIMITING MEMBRANE REPOSITION
Macular hiatus (MH) refers to a tissue defect in the photoreceptor cell layer of the inner boundary membrane of the optic disc in the macular region.
- Trial name
- NCT06359548
- Testing
- Peeled ILM Reposition, ILM Peeling
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Holes
GaslEss Macular Hole Surgery
Macular holes are a hole in the centre of the retina, the light-sensing layer in the back of the eye. They cause a central 'blind spot' in the vision, which can be very disabling for patients.
- Trial name
- GEM (NCT06079593)
- Testing
- Gasless Macular hole surgery, Standard Macular hole surgery
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust