Clinical trials: Macular Holes
Comparison of 3D Visualization and Microscope for VR Surgery
Damages From Macular Grasping During Vitrectomy Comparing Traditional and 3D Microscope
Randomized, prospective, descriptive and comparative clinical study. The comparison is between a group of patients affected by macular pucker or macular hole, whose macular peeling is performed using a traditional optical…
- Trial name
- NCT05113212
- Testing
- Macular surgery with NGENUITY surgical display system, Macular surgery with standard operating microscope
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Anna Rita Daniele, MD
Macular Holes
ILM Flap Transposition Versus ILM Peeling for Macular Holes: a Pilot Study
Patients with macular hole <400µm will be randomized for ILM flap Transposition and ILM Peeling for surgical repair of macular holes
- Trial name
- NCT03646695
- Testing
- ILM flap transposition, ILM peeling
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Ophthalmologic Complication, Epiretinal Membrane
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
Assessing metamorphopsia and quality of vision pre and post epiretinal and macular hole surgery
- Conditions
- Ophthalmologic Complication, Epiretinal Membrane, Metamorphopsia, Macular Holes
- Trial name
- MQUEST (NCT05171621)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Hayley Westwood
Idiopathic Macular Hole
Unveiling Preclinical Idiopathic Macular Hole Formation
A macular hole is a rupture in the macula. In terms of pathogenesis, as much as 80% are idiopathic (Idiopathic Macular Hole, IMH).
- Trial name
- IMH_2012 (NCT02180633)
- Testing
- Optical Coherence Tomography Scan
- Where
- 7 sites in Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Macular Hole
Internal Limiting Membrane Peeling for Large Macular Holes
Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and…
- Trial name
- NCT00190190
- Testing
- With Peeling of Limiting the Intern of the Retina, Internal limiting membrane peeling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinal Detachment, Macular Pucker
Zeiss RESIGHT Disposable Lenses Evaluation Study
To evaluate the intra-operative efficacy of a new intra-operative viewing device.
- Conditions
- Retinal Detachment, Macular Pucker, Macular Holes, Vitreomacular Traction
- Trial name
- RESIGHT (NCT05860985)
- Testing
- ZEISS disposable
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Macular Holes, High Myopia
Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic Eyes
Full-thickness macular Hole associated with macular detachment is a one of the maculopathies of high myopia. There is controversy in the primary treatment for this situation.
- Conditions
- Macular Holes, High Myopia, Macular Detachment
- Trial name
- NCT03433547
- Testing
- Buckle, Vitrectomy, Limbal paracentesis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Macular Holes
Human Amniotic Membrane Plug for Large Macular Holes
This is a prospective, interventional, consecutive case series conducted in Alexandria university. The aim of the study is to evaluate the therapeutic efficacy of human amniotic membrane in promoting closure of large macular…
- Trial name
- NCT03917602
- Testing
- human amniotic membrane plug with vitrectomy
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- University of Alexandria
Macular Holes
Double Flap Technique for Macular Hole
Double flapping technique to close the macular hole.
- Trial name
- NCT05269563
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 20 people
- Sponsor
- Omer Othman Abdullah
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Macular Hole, RPE Detachment
Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies
The purpose of this study is to compare the newly released Spectral OCT/SLO (OTI, Toronto, Canada) with the Zeiss Stratus OCT (Carl-Zeiss Meditec, Dublin, CA) with regards to the quality of the images obtained as well as the ease…
- Conditions
- Macular Hole, RPE Detachment, Epiretinal Membrane, Posterior Vitreous Detachment
- Trial name
- NCT00408720
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The New York Eye & Ear Infirmary
Ophthalmopathy
Autologous Blood for Full-thickness Macular Hole
Autologous blood for primary and recurrent holes
- Trial name
- NCT05494229
- Testing
- Pars-plana vitrectomy
- Where
- Iraq
- Volunteers
- 5 people
- Sponsor
- Omer Othman Abdullah
Epiretinal Membrane, Macular Hole
Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
The aim of this study is to test the efficacy of the combination of dye Lutein, Zeaxanthin and brilliant blue to stain the internal limiting membrane as well as the epiretinal membranes during the Vitrectomy surgery.
- Conditions
- Epiretinal Membrane, Macular Hole, Proliferative Diabetic Retinopathy
- Trial name
- NCT01627977
- Testing
- Dye of Lutein, Zeaxanthin and Brilliant Blue
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Epiretinal Membrane, Macular Hole
Fourier Transformed Infrared Spectroscopy in Macular Surgery
Epiretinal membranes (ERM) are disorders leading to vision loss and metamorphopsia. Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of ERM.
- Trial name
- NCT03452748
- Testing
- FTIR spectroscopy
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Idiopathic Macular Hole, Effective Prone Time
Analysis of Novel Positioning Sensor-assisted Postoperative Position Correction and Effective Prone Time Recorded in Patients With Different Prone Times After Macular Hole Surgery
Idiopathic macular hole (IMH) is a fundus disease without clear etiology, most often seen in healthy women over 50 years of age, and is often associated with ocular manifestations such as loss of central vision and visual…
- Trial name
- NCT05757349
- Testing
- Face-down position time 1-day, Face-down position time 3-day
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin Medical University Eye Hospital
Macular Hole
Objective Evaluation of Postoperative Positioning in Macular Hole Surgery
The macular hole formation takes place in the centre of the retina. A closure of the macular hole is believed to take place if the central retinal area is kept dry in the postoperative period.
- Trial name
- NCT02295943
- Testing
- Positioning measuring device
- Where
- 4 sites in Norway
- Volunteers
- 205 people
- Sponsor
- Helse Stavanger HF
Platelet-rich Fibrin, Macular Holes
Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
The goal of this clinical trial is to observe the role of PRF in treating ophthalmic diseases.The efficacy and safety of PRF were validated for four ophthalmic conditions: macular hole, pterygium, corneal ulcer, and patients…
- Conditions
- Platelet-rich Fibrin, Macular Holes, Pterygium, Glaucoma
- Trial name
- NCT06200727
- Testing
- PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Lei Du
Macular Hole
Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition
ILM-flap (internal limiting Membrane-flap) transposition is a new surgical option in repair of macular holes, therefore one year outcomes are needed to better evaluate that method.
- Trial name
- NCT03465865
- Testing
- optical coherence tomography
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Macular Holes
Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors
Aim of the Study:To report the structural and visual outcomes of plasma rich in growth factors in closure of challenging macular holes
- Trial name
- NCT06115005
- Testing
- Plasma rich in growth factors ( PRGF )
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minia University
Macular Holes
Infracyanine Green vs Brilliant Blue G in Macular Hole Inverted Flap Surgery: A Swept Source OCT Analysis.
This study will compare by swept-source optical coherence tomography (SS-OCT) the retinal morphology after inverted internal limiting membrane (I-ILM) flap vitreoretinal surgery for medium-to-large macular holes using…
- Trial name
- NCT03946267
- Testing
- Inverted inner limiting membrane flap technique for large full thickness macular holes
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo