Clinical trials: Macular Holes
Full Thickness Macular Hole
Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole
This is a pilot randomised controlled trial (RCT) to investigate the effect of postoperative face-down positioning on the outcome of macular hole surgery.
- Trial name
- NCT01226160
- Testing
- Postoperative face-down posturing, Postoperative non-posturing group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Retinal Perforations, Myopia, Degenerative
Corneal Flap Transplantation for Macular Hole Repair of High Myopia
The goal of this clinical trial is to learn about an innovative surgical technique for macular hole repair. This technique is for patients with high myopia using pars plana vitrectomy (PPV) combined with corneal flap…
- Trial name
- NCT05875909
- Testing
- corneal flap transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First People's Hospital of Hangzhou
Macular Hole
Alleviated Positioning for Small Macular Holes
Rational of the study: There are arguments to think that the closure of macular holes can be obtained without a strict positioning under certain conditions, i.e.
- Trial name
- NCT00190164
- Testing
- Macular hole surgery with alleviated positioning, Macular hole surgery with no alleviated positioning
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Macular Holes, Intraocular Lens Opacification
Oral Sedation in Vitreoretinal Surgery
The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.
- Conditions
- Macular Holes, Intraocular Lens Opacification, Vitrectomy, Vitreous Hemorrhage
- Trial name
- NCT04346095
- Testing
- Oral Sedatives with or Without Analgesia, Intravenous Sedatives with or Without Analgesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC
Macular Hole
Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery
The purpose of this study is to determine the effects of two different internal limiting membrane (ILM) peeling area on anatomical closure outcomes after macular hole surgery measured by optical coherence tomography (OCT).
- Trial name
- NCT02930369
- Testing
- ILM peeling surgery
- Volunteers
- 128 people
- Sponsor
- Peking University People's Hospital
Macula Hole
Macular Hole Surgery With Temporal Inverted Internal Limiting Membrane Flap (MARTIAL)
Since 1991, idiopathic macular holes (MH) can benefit from an effective treatment initially involving pars plana vitrectomy, stripping of epiretinal membranes and intraocular gas tamponade followed by facedown positioning.
- Trial name
- MARTIAL (NCT03287102)
- Testing
- Macular hole surgery
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Idiopathic Macular Hole, Effective Prone Time
Analysis of Novel Positioning Sensor-assisted Postoperative Position Correction and Effective Prone Time Recorded in Patients With Different Prone Times After Macular Hole Surgery
Idiopathic macular hole (IMH) is a fundus disease without clear etiology, most often seen in healthy women over 50 years of age, and is often associated with ocular manifestations such as loss of central vision and visual…
- Trial name
- NCT05757349
- Testing
- Face-down position time 1-day, Face-down position time 3-day
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Tianjin Medical University Eye Hospital
Macular Holes
Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery
The objective is to determine whether a recovery of the microstructures of the foveal photoreceptors after macular hole (MH) closure is correlated with the best-corrected visual acuity (BCVA) is determined.
- Trial name
- NCT01306487
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 58 people
- Sponsor
- Kyorin University
Macular Holes, Optical Coherence Tomography
Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness Idiopathic Macular Holes < 600 μm With Air Versus 10% SF6 Tamponade
State of the art treatment for idiopathic macular holes consists of pars plana vitrectomy, internal limiting membrane staining with a blue colouring dye, internal limiting membrane peeling and filling of the vitrectomized space…
- Trial name
- NCT05223205
- Testing
- Air, 10% SF6 and 90% air
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Macular Holes
Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macular Hole
The main objective of this study is to evaluate the therapeutic effectiveness of the internal limiting membrane (ILM) peeling and translocation surgery compared to the conventional surgical approach for treating large idiopathic…
- Trial name
- NCT06063005
- Testing
- Translocation ILM Flap, ILM Peeling
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Macular Disease
Epiretinal Proliferation in Eyes With Full Thickness Macular Hole
We evaluated preoperative and postoperative optical coherence tomograpghic images in eyes with full thickness macular hole (FTMH) whether the epiretinal proliferation (EP) was detected and detection of EP was correlated to the…
- Trial name
- NCT03376776
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 390 people
- Sponsor
- Kyorin University
Intraocular Pressure,, Postoperative Complications
Primary Vitrectomy for the Treatment of Retinal Detachment in Highly Myopic
Purpose: To assess the functional and anatomical outcome of primary vitrectomy without scleral buckling for rhegmatogenous retinal detachment (RRD) in highly myopic eyes with axial length over 30 mm.
- Trial name
- NCT01480505
- Testing
- Pars plana vitrectomy with gas tamponade
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ophthalmopathy
Single Superior ILM/ERM Flap for the FTMH.
In this study, the investigators will make the only upper flap either from the internal limiting membrane or from the epiretinal membrane to cover the full thickness macular hole.
- Trial name
- NCT05494242
- Testing
- Surgical intervention
- Where
- Iraq
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Omer Othman Abdullah
Macular Hole, Visual Acuity
Combined Versus Successive Macular Hole and Cataract Surgery
The purpose of this study is to compare functional and anatomical results of a combined surgery and two time surgery for macular hole and cataract extraction in one hundred and twenty patients (120 eyes) with idiopathic Macular…
- Trial name
- NCT01069029
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Epimacular Gliosis, Macular Hole
Observational Study - ILM Peeling
This observational study investigates the effects of epimacular membrane peeling on the structure and function of the retina.
- Trial name
- NCT01083056
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Macular Hole Surgery
Autologous Tenon's Capsule Graft for Refractory Macular Holes
This prospective interventional study evaluates the anatomical and functional outcomes of autologous Tenon's capsule grafting in patients with refractory full-thickness macular holes.
- Trial name
- ATCG-RMH (NCT07318961)
- Testing
- Autologous Tenon's Capsule Graft Placement
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
Proliferative Diabetic Retinopathy, Macular Degeneration
Analysis of Aqueous and Vitreous Humor
Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate.
- Conditions
- Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma
- Trial name
- ARK (NCT02067013)
- Testing
- Ranibizumab, No Ranibizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- California Retina Consultants
Full Macular Hole
Changes InMPOD After Full-thickness Macular Hole Closure
The notable increase in MPOD following successful surgery suggests its potential role as a valuable adjunctive biomarker associated with a good visual prognosis following this type of macular hole surgical interventions.
- Trial name
- NCT06664515
- Testing
- Ciro Costagliola
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Federico II University
Macular Hole, Epiretinal Membrane
Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery
Study designed to evaluate the safety and efficacy of double staining with brilliant blue G 0.025% as an adjuvant to macular surgery. Patients undergoing surgery for macular hole or epiretinal membrane will be included.
- Trial name
- NCT01820520
- Testing
- brilliant blue G
- Where
- Mexico
- Volunteers
- 22 people
- Sponsor
- Asociación para Evitar la Ceguera en México