Clinical trials: Macular Holes
Vitreomacular Adhesion Including Macular Hole
Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole
The purpose of this study is to evaluate the treatment of symptomatic vitreomacular adhesion / (VMT) including macular hole with ocriplasmin.
- Trial name
- OASIS (NCT01429441)
- Testing
- Ocriplasmin
- Where
- 25 sites in United States
- Volunteers
- 220 people
- Sponsor
- ThromboGenics
Macular Holes
Postoperative Positioning After Surgery for Macular Holes
Idiopathic macular holes are an important cause of visual loss. Macular holes can be treated by surgically removing the vitreous gel and injecting intraocular gas.
- Trial name
- NCT01974310
- Testing
- Vitrectomy & Intraocular gas fill, Postoperative face-down positioning
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Macular Holes
Preoperative Progression of Macular Holes
Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre-optical coherence tomography era.
- Trial name
- NCT02203929
- Where
- Denmark
- Volunteers
- 37 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Idiopathic Macular Holes
Brillant Blue Versus Indocyanine Green for Macular Hole Surgery
Macular Hole Surgery with two different Dyes
- Trial name
- NCT00757471
- Testing
- Brillant Blue, Indocyanine Green
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Macular Hole Surgery
Optical Coherence Tomography-based Positioning for Macular Hole Surgery
The efficacy of macular hole (MH) surgery with the halting of prone positioning by monitoring the MH closure in the swept source optical coherence tomographic (SS-OCT) images was compared with the surgery by the surgeon's…
- Trial name
- NCT02650739
- Testing
- Macular hole surgery
- Volunteers
- 125 people
- Sponsor
- Kyorin University
Macular Holes
Extent of ILM Removal and Its Impact on Outcomes of MH Surgery
Eligible patients who were scheduled for surgery for idiopathic macular hole (MH) were equally randomized to small extent group or large extent group depending on the extent of internal limiting membrane (ILM) to be removed.
- Trial name
- NCT02010138
- Testing
- small-extent peeling, large-extent peeling
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Macular Hole
Fundus Autofluorescence After Macular Hole Surgery
Funds autofluorescence (FAF) indicates hyper fluorescence at the macular hole in the patients with macular hole. Investigators investigate the association between FAF and visual acuity, recovery of foveal microstructure, and FAF…
- Trial name
- NCT02628262
- Testing
- Vitrectomy with internal limiting membrane removal and gas tamponade
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Makoto Inoue
Macular Hole Retinal Detachment, Myopic Traction Maculopathy
Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy
The medical records of 16 eyes of 16 patients with macular hole retinal detachment or myopic traction maculopathy who received viterctomy including internal limiting membrane peeling and scleral shorting surgery were reviewed.
- Trial name
- NCT02528045
- Testing
- Vitrectomy with scleral shortening
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Kyorin University
Macular Hole, Macular Pucker
Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy
To compare postoperative inflammation and breakdown of blood-retinal barrier as measured by a laser flare-cell meter in 20G versus 23G vitrectomy.
- Trial name
- 20Gvs23G (NCT01969929)
- Testing
- 20G Vitrectomy, 23G vitrectomy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Cologne
Macular Hole
An Objective Evaluation of Postoperative Positioning in Macular Hole Surgery
The macular hole formation takes place in the centre of the retina. A closure of the macular hole is believed to take place if the central retinal area is kept dry in the postoperative period.
- Trial name
- NCT02011165
- Testing
- Positioning measuring device
- Where
- 2 sites in Norway
- Volunteers
- 43 people
- Sponsor
- Helse Stavanger HF
Trauma, Macular Hole
Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole
The purpose of this study is to compare the anatomical and visual recovery of eyes with traumatic macular hole (TMH) following either early vitrectomy or 6-month observation.
- Trial name
- NCT01509092
- Testing
- vitrectomy surgery
- Where
- 8 sites in China
- Volunteers
- 44 people
- Sponsor
- Peking University Third Hospital
Epimacular Gliosis, Macular Hole
Observational Study - ILM Peeling
This observational study investigates the effects of epimacular membrane peeling on the structure and function of the retina.
- Trial name
- NCT01083056
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Idiopathic Macular Hole
Trial of Prognostic Factors and Surgical Methods for the Treatment of Idiopathic Macular Holes
The project is a randomized clinical trial with a follow up time of 12 months comparing the effects of surgical treatment of idiopathic macular holes.
- Trial name
- NCT00302328
- Testing
- macular hole operation
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or,, Large Size Macular Hole (Diameter > 600 Microns) or
The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes
The purpose of this study is to determine the effectiveness of intravitreal autologous platelet concentrate (APC) injection during the surgery for refractory macular holes.
- Conditions
- Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or,, Large Size Macular Hole (Diameter > 600 Microns) or, Recurred or Failed Macular Hole From Previous Surgery, or Chronic Macular Hole (Symptom Duration > 6 Months)
- Trial name
- NCT02081170
- Testing
- Autologous platelet concentrate
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Macular Holes
Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis
Since Kelly and Wendel first reported successful closure of idiopathic macular holes (MH) by vitrectomy in 1991, many surgical modifications have been made to improve the anatomical and visual outcomes of this surgery.
- Trial name
- NCT01687829
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yifan Feng
Macular Hole
Air Tamponade in Macular Hole Surgery
Macular hole is a hole formation which takes place in the center of the retina. Such a hole needs surgical steps in order to close. Closure of the macular hole will lead to a substantially improvement of vision in most cases.
- Trial name
- NCT01680068
- Testing
- Pars plana vitrectomy and postoperative air tamponade
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Helse Stavanger HF
Macular Hole
Asymmetrical Recovery of Cone Outer Segment Tips and Foveal Displacement After Macular Hole Surgery
Evaluation of asymmetry in recovery of cone outer segment tips and foveal displacement after macular hole surgery
- Trial name
- NCT01959776
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 35 people
- Sponsor
- Kyorin University
Macular Hole
Optical Coherence Tomography in Gas-filled Eyes
The aim of this study is to determine the condition to detect the status of a macular hole by spectral domain optical coherence tomography (SD-OCT) in gas-filled eyes.
- Trial name
- NCT01266746
- Testing
- Vitreous surgery
- Where
- Japan
- Volunteers
- 37 people
- Sponsor
- Kyorin University
Macular Hole
Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Macular Hole
To evaluate the correlations between anatomical and functional changes studied with microperimetry (MPM) and spectral-domain OCT (SD-OCT) in patients after successful repair of idiopathic macular hole (MH).
- Trial name
- NCT01757600
- Testing
- Microperimetry
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Holes
Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery
The objective is to determine whether a recovery of the microstructures of the foveal photoreceptors after macular hole (MH) closure is correlated with the best-corrected visual acuity (BCVA) is determined.
- Trial name
- NCT01306487
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 58 people
- Sponsor
- Kyorin University