Clinical trials: Macular Holes
Macular Holes
Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery
Spectral domain optical coherence tomography (SD-OCT) was used to determine whether the repair of photoreceptor cone outer segment tips defect is significantly correlated with the visual outcomes after macular hole surgery.
- Trial name
- NCT01381965
- Testing
- Vitreous surgery for macular hole
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Kyorin University
Stage 2 or 3 Full Thickness Macular Hole
Full Thickness Macular Hole and Internal Limiting Membrane Peeling Study
A macular hole is a fairly common problem in the retina and is an important cause of loss of central vision. The aim of this study is to determine whether, in patients with a stage 2 or 3 full thickness macular hole (FTMH)…
- Trial name
- FILMS (NCT00286507)
- Testing
- Vitrectomy, post hyaloid detachment and gas injection with or without ILM peel.
- Where
- 9 sites in Ireland, United Kingdom
- Volunteers
- 141 people
- Sponsor
- University of Aberdeen
Full Thickness Macular Hole
Protocol for RCT of Posturing in Phacovitrectomy for Full Thickness Macular Hole (FTMH)
The purpose of this study is to determine the effect of postoperative posturing on the outcome of macular hole surgery. Current practice is divided; some individuals are advised to posture face-down for 10 days and others are…
- Trial name
- NCT01020760
- Testing
- Face down posture
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Macular Holes
Elongation of Foveal Tissue After Macular Hole Surgery
In our experience, elongation of foveal tissue after macular hole surgery which was undetectable by conventional time-domain optical coherence tomography was often observed on spectral-domain optical coherence tomography images.
- Trial name
- NCT01471912
- Testing
- pars plana vitrectomy and fluid gas exchange
- Where
- South Korea
- Volunteers
- 31 people
- Sponsor
- Samsung Medical Center
Macular Pucker, Macular Hole
Brilliant Blue Versus Indocyanine Green
A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.
- Conditions
- Macular Pucker, Macular Hole, Vitreoretinal Surgery
- Trial name
- NCT01083004
- Testing
- Indocyanine green, Brilliant blue arm
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Macular Holes
Evaluation of Anatomic and Visual Outcomes of Initially Closed Macular Holes
To evaluate the anatomic and visual outcomes in patients with initially closed macular holes after vitreoretinal surgery and with one to seven years of follow-up.
- Trial name
- NCT01229657
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sun Yat-sen University
Macular Holes
Inverted ILM Repositioning as Treatment for Full Thickness Macular Holes
The purpose of this study is to evaluate the efficacy and safety of surgical treatment of FTMH using an inverted ILM repositioning to improve anatomical and functional outcomes in patients with a macular hole.
- Trial name
- NCT01228188
- Testing
- Inverted ILM Repositioning
- Where
- Poland
- Volunteers
- 25 people
- Sponsor
- Military Institute od Medicine National Research Institute
Full Thickness Macular Hole
Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole
This is a pilot randomised controlled trial (RCT) to investigate the effect of postoperative face-down positioning on the outcome of macular hole surgery.
- Trial name
- NCT01226160
- Testing
- Postoperative face-down posturing, Postoperative non-posturing group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Macular Hole, Visual Acuity
Combined Versus Successive Macular Hole and Cataract Surgery
The purpose of this study is to compare functional and anatomical results of a combined surgery and two time surgery for macular hole and cataract extraction in one hundred and twenty patients (120 eyes) with idiopathic Macular…
- Trial name
- NCT01069029
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Idiopathic Macular Hole
Outcome of Idiopathic Macular Hole
The purpose of this study is to evaluate the role of cataract surgery and cystoid macular edema (CME) on reopening of idiopathic macular holes (IMH).
- Trial name
- NCT00941291
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Pucker, Macular Hole
Membrane Blue Versus Infracyanine Green
To compare possible toxicities of membrane blue and infracyanine green in vivo by macular function and peripheral visual field.
- Trial name
- NCT00555269
- Volunteers
- 30 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Macular Hole, Proliferative Diabetic Retinopathy
Macular Hole in Diabetic Retinopathy
Macular hole in proliferative diabetic retinopathy with fibrovascular proliferation may have unique features. Internal limiting membrane peeling facilitates hole closure only in cases with shallow macular detachment.
- Trial name
- NCT00737074
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- National Taiwan University Hospital
Macular Hole
Alleviated Positioning for Small Macular Holes
Rational of the study: There are arguments to think that the closure of macular holes can be obtained without a strict positioning under certain conditions, i.e.
- Trial name
- NCT00190164
- Testing
- Macular hole surgery with alleviated positioning, Macular hole surgery with no alleviated positioning
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Macular Hole
Internal Limiting Membrane Peeling for Large Macular Holes
Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and…
- Trial name
- NCT00190190
- Testing
- With Peeling of Limiting the Intern of the Retina, Internal limiting membrane peeling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epiretinal Membrane, Macular Hole
Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal
The purpose of this trial is to compare the ability of two doses of OT-551 ophthalmic solution and drug-free solution to safely and effectively prevent or delay the progression of nuclear cataracts that frequently develop as a…
- Trial name
- NCT00333060
- Testing
- OT-551 ophthalmic solution
- Where
- 16 sites in United States
- Volunteers
- 164 people
- Sponsor
- Othera Pharmaceuticals
Epiretinal Membranes, Macular Holes
Blue-Blocking IOLs in Combined Surgery
Although commonly used in cataract surgery, the use of the blue light-filter IOLs in vitrectomy combined with cataract surgery has not been reported yet.
- Conditions
- Epiretinal Membranes, Macular Holes, Cataract
- Trial name
- NCT00537992
- Testing
- combined surgery
- Volunteers
- 60 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Idiopathic Macular Hole
Indocyanine Green or Trypan Blue for Delamination of the Internal Limiting Membrane in Macular Hole Surgery
To evaluate the anatomical and visual outcomes after vitrectomy and internal limiting membrane (ILM) peeling with indocyanine green (ICG) or trypan blue (TB) for idiopathic macular hole repair in a prospective randomized trial.
- Trial name
- NCT00419185
- Testing
- Delamination of the Internal limiting membrane
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Luebeck
Macular Hole, RPE Detachment
Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies
The purpose of this study is to compare the newly released Spectral OCT/SLO (OTI, Toronto, Canada) with the Zeiss Stratus OCT (Carl-Zeiss Meditec, Dublin, CA) with regards to the quality of the images obtained as well as the ease…
- Conditions
- Macular Hole, RPE Detachment, Epiretinal Membrane, Posterior Vitreous Detachment
- Trial name
- NCT00408720
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The New York Eye & Ear Infirmary