Clinical trials: Macular Oedema
Diabetic Macular Edema
Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial
The purpose of this study is to compare the efficacy and safety of intravitreal injection of bevacizumab alone versus bevacizumab combined with triamcinolone for treatment of refractory diabetic macular edema.
- Trial name
- NCT00370422
- Testing
- Triamcinolone, Bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Diabetes, Diabetic Macular Edema
OCT Screening for Diabetic Macular Edema at Primary Diabetes Care Visits
The purpose of this protocol is to determine whether point of care optical coherence tomography (OCT) imaging combined with an OCT-guided retinal referral algorithm at primary diabetes care visits increases rates of retina…
- Conditions
- Diabetes, Diabetic Macular Edema, Diabetic Retinopathy
- Trial name
- DME FOUND (NCT01875783)
- Testing
- OCT imaging
- Where
- 4 sites in United States
- Volunteers
- 385 people
- Sponsor
- Joslin Diabetes Center
Diabetic Macular Edema, Pars Plana Vitrectomy
Compare the Efficacy of VItrectomy Combined With DExamethasone Implant Versus With Aflibercept in DME Patients Diagnosed by Intraoperative OCT (the VIDEO Study): Study Protocol for a Randomized Controlled Trial
Diabetic macular edema (DME) is the main cause of severe vision loss in diabetic retinopathy. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) and Ozurdex are two safe and effective ways to treat DME.
- Conditions
- Diabetic Macular Edema, Pars Plana Vitrectomy, Dexamethasone Intravitreal Implant, Intraoperative Optical Coherence Tomography
- Trial name
- NCT05990829
- Testing
- Ozurdex, Aflibercept
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tianjin Medical University Eye Hospital
Diabetic Retinopathy, Diabetic Macular Edema
Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy
The objective of this study is to evaluate the safety and efficacy of APX3330 to treat diabetic retinopathy (DR) and diabetic macular edema (DME).
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, NPDR - Non Proliferative Diabetic Retinopathy, PDR - Proliferative Diabetic Retinopathy
- Trial name
- ZETA-1 (NCT04692688)
- Testing
- APX3330
- Where
- 24 sites in United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Macular Edema, Cystoid Macular Edema
Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma
To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex) and compare it with safety and efficacy of intravitreal bevacizumab in eyes with macular edema after plaque radiotherapy of uveal melanoma.
- Conditions
- Macular Edema, Cystoid Macular Edema, Uveal Melanoma, Radiation Maculopathy
- Trial name
- NCT01471054
- Testing
- Ozurdex, Bevacizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arman Mashayekhi
Diabetic Retinopathy, Diabetic Macular Edema
Conjunctival Flora Patterns After Serial Intravitreal Injections in Diabetic Patients
The aim of this study is to investigate the conjunctival bacterial flora and antibiotic resistance patterns following serial intravitreal injections of anti-VEGF in diabetic patients, using a povidone-iodine preparation without…
- Trial name
- NCT02337972
- Testing
- povidone-iodine 4%
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Cystoid Macular Edema, Fuchs Dystrophy
Descemet Membrane Endothelial Keratoplasty vs. Descemet's Stripping With Endothelial Keratoplasty vs. Descemet Stripping Only
This study aims to evaluate and compare incidence of post-operative cystoid macular edema (CME) after Descemet Membrane Endothelial Keratoplasty (DMEK), Descemet's Stripping Automated endothelial Keratoplasty (DSEK) and Descemet…
- Trial name
- NCT04527523
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Wake Forest University Health Sciences
Diabetic Macular Edema
Comparative Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea® in Subjects With Diabetic Macular Edema (DME)
Three hundred and twenty-four (324) eligible adult subjects with diabetes mellitus with central DME involvement to be randomized 1:1 to intravitreal treatment with MYL-1701P or Eylea®.
- Trial name
- DME (NCT03610646)
- Testing
- MYL-1701P, Eylea
- Where
- 73 sites in United States, Czechia and 7 more
- Volunteers
- 355 people
- Sponsor
- Mylan Pharmaceuticals Inc
Age-related Macular Degeneration, Diabetic Retinopathy
Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study)
To compare the efficacy and comfort of two FDA approved pre-injection antiseptics when used for intravitreal injections.
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- PAVE (NCT04018482)
- Testing
- Povidone Iodine, Hypochlorous Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- California Retina Consultants
Diabetic Macular Edema
Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema
This study will evaluate the safety and efficacy of an intravitreal insert of fluocinolone acetonide for the treatment of diabetic macular edema.
- Trial name
- FAME (NCT00344968)
- Testing
- fluocinolone acetonide, Standard of care laser photocoagulation
- Where
- United States
- Volunteers
- 956 people
- Sponsor
- Alimera Sciences
Blepharoptosis, Age-Related Macular Degeneration
Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study
Intravitreal anti-VEGF injections are a mainstay of treatment for retinal diseases such as neovascular age-related macular degeneration, diabetic macular edema and retinal vein occlusion, and usually require repeated…
- Conditions
- Blepharoptosis, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT07821450
- Testing
- Repeated intravitreal anti-VEGF injection with eyelid speculum
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abdulkadir Küçük
Macular Edema, Epiretinal Membrane
Intravitreal Dexamethasone Implant for Persistent Macular Thickening and Edema After Vitrectomy for Epiretinal Membrane
This study seeks to evaluate the effect of the intravitreal 0.7mg dexamethasone implant on central macular thickness and visual acuity in those patients with persistent macular edema after pars plana vitrectomy for epiretinal…
- Conditions
- Macular Edema, Epiretinal Membrane, Vitrectomy
- Trial name
- DEMO (NCT02995746)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Macular Edema Due to Diabetes Mellitus
Home Monitoring of Diabetic Macular Edema
Diabetic macular edema (DME) is part of diabetic retinopathy (DR) and a leading cause of central visual loss in people with diabetes .
- Trial name
- NCT05223569
- Testing
- Home OCT monitoring model, Hospital-based monitoring with a staff-administrated OCT
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Retinal Diseases
Efficacy of Ranibizumab Therapy With Aflibercept in Patients With Diabetic Macular Edema
The purpose of this study in to compare the efficacy of treatment of diabetic macular edema (DME) using Ranibizumab (Lucenti®), Aflibercept (Eylea®) and Aflibercept (Eylea®) plus Ranibizumab (Lucentis®).
- Trial name
- NCT02646670
- Testing
- Ranibizumab, Aflibercept, Ranibizumab and Aflibercept
- Volunteers
- 20 people
- Sponsor
- Instituto de Olhos de Goiania
Diabetic Retinal Edema
Treatment of Diabetic Macular Edema (DME) With Anti-VEGF and Focal Laser
Long-term follow-up of patients with diabetic macular edema (DME) treated with intravitreal anti-vascular endothelial growth factor (anti-VEGF) combined focal laser and identification of prognostic morphological characteristics.
- Trial name
- NCT03590444
- Testing
- Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Hospital Hietzing
Uveitis
Efficacy, Safety and Tolerability of Repeated Dosis of Intravitreous Bevacizumab in Uveitic Macular Oedema
The purpose of this study is to determine whether intravitreous bevacizumab or intravitreous triamcinolone acetonide are effective and safe in the treatment of uveitic macular oedema
- Trial name
- EBEV (NCT01095809)
- Testing
- bevacizumab, triamcinolone acetonide
- Where
- 5 sites in Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Clinic of Barcelona
Diabetic Macular Edema
A Study to Evaluate the Effectiveness and Safety of OZURDEX® in Patients With Diabetic Macular Edema But Never Treated
This study will evaluate the efficacy and safety of OZURDEX in patients with Diabetic Macular Edema when used in a real world setting in Spain and Portugal.
- Trial name
- EYEberia (NCT03953807)
- Testing
- Dexamethasone Intravitreal Implant
- Where
- 26 sites in Portugal, Spain
- Volunteers
- 82 people
- Sponsor
- Allergan
Diabetic Macular Edema, Diabetes
Laser Versus Vitrectomy Versus Intravitreal Triamcinolone Injection for Diabetic Macular Edema
Macular edema is the main cause of vision loss in diabetic patients. Its treatment is mainly based on laser photocoagulation, but has limited results.
- Trial name
- VITRILASE (NCT00764244)
- Testing
- Vitrectomy, Intravitreal triamcinolone injections, Laser photocoagulation
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Macular Edema
Study Comparing Two Populations of Patients Treated With Anti VEGF for Diabetic Macular Edema, One Being Followed at the Hospital and the Other One Being Followed at Home Using a Software Allowing Self-assessment of Visual Acuity
Verify the reliability of VA measured every week at home, by the patient using a TC, compared to the reliability of VA also measured by the patient using a TC but every 2 month at the hospital, during standard DME follow-up visits
- Trial name
- NCT04776343
- Testing
- telemedecine follow-up
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Macular Edema
Study Assessing AR-1105 in Subjects With Macular Edema Due to Retinal Vein Occlusion (RVO)
This study will evaluate the safety, tolerability and efficacy of AR-1105 (dexamethasone implant) for the treatment of macular edema (ME) due to retinal vein occlusion (RVO).
- Trial name
- NCT03739593
- Testing
- AR-1105-CF1, AR-1105-CF2
- Where
- 11 sites in United States
- Volunteers
- 49 people
- Sponsor
- Aerie Pharmaceuticals