Clinical trials: Macular Pigment
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
Diabetes Visual Function Supplement Study
This study will evaluate the effects of a novel multi-component dietary supplement on the visual function and retinal structure of patients with diabetes with both no diabetic retinopathy and mild to moderate diabetic…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Non-proliferative Diabetic Retinopathy
- Trial name
- DiVFuSS (NCT01646047)
- Testing
- multi-component nutritional supplement capsules, multi-component dietary supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- ZeaVision, LLC
Persons Issued From Amd Parents
Lutein Influence on Macula of Persons Issued From Amd Parents
Age-related macular degeneration (AMD) is a degenerative disease of the centre of the retina (named macula) and is the leading cause of blindness in industrialized countries.
- Trial name
- LIMPIA (NCT01269697)
- Testing
- Nutrof Total
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Vision, Entoptic
Macular Pigment and Glare Disability
The purpose of this study is: I. To measure MP optical density (MPOD) in two groups (experimental and placebo) of 50 subjects each (N = 100), during an Lutein + Zeaxanthin supplementation period of 12 months. II.
- Trial name
- MP-GD (NCT00909090)
- Testing
- 12 mg Lutein + Zeaxanthin
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Retinal Ageing
Carotenoid Supplementation and Normal Ocular Health
Normal ageing affects vision as a result of preretinal and retinal changes. Photoreceptors, the light sensitive cells in the retina, degenerate and the rods (responsible for night vision) are most susceptible to damage with…
- Trial name
- NCT02147171
- Testing
- VisionAce
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Cognitive Change, Achievement
Enhancing Children's Cognitive Function and Achievement Through Carotenoid Consumption
The aim of this study is to test the casual relationship between carotenoid supplementation, cognitive function, and achievement over a school-year.
- Conditions
- Cognitive Change, Achievement, Macular Pigmentation
- Trial name
- NCT05177679
- Testing
- Active supplement
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Age-Related Macular Degeneration
The Role of Inflammation in AMD and Related Disorders
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
- Trial name
- NCT02588378
- Testing
- multi-modal cSLO imaging
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Changes in Macular Pigment Optical Density
Regional Kale as Source of Lutein and Zeaxanthin to Improve Vision of AMD-patients
The age-related macular degeneration (AMD) is an age-dependent, multi-factorial disease. In Western industrial countries, it is the main cause of visual impairments. In Germany, approximately 4.5 million people suffer from AMD.
- Trial name
- KALESIGHT (NCT02136303)
- Testing
- S1: Dosage-dependency, S2: Kale extract versus kale purée, S3: Kale extract: AMD-patients
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jena
Pigment Epithelial Detachment
iSONEP to Treat Persistent Pigment Epithelial Detachment (PED) in Subjects With Exudative Age-Related Macular Degeneration (AMD) or Polypoidal Choroidal Vasculopathy (PCV)
LT1009-Oph-002 is a Phase 1b study designed to evaluate the safety and potential efficacy of iSONEP following one, two or three injections of iSONEP, as needed, for the treatment of Pigment Epithelial Detachment (PED) secondary…
- Trial name
- PED (NCT01334255)
- Testing
- iSONEP (sonepcizumab/LT1009)
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Lpath, Inc.
Neovascular Age-related Macular Degeneration
Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor
Purpose: To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term…
- Trial name
- NCT03679156
- Testing
- OCT
- Volunteers
- 18 people
- Sponsor
- Hospital Hietzing
Age Related Macular Degeneration
Association of MPOD Values With Blue Light.
This study aims to investigate in healthy adults 18-65 years of age the association of electronic device blue light exposure and macular pigment optical density (MPOD) considering usual dietary intake of lutein and zeaxanthin…
- Trial name
- AMPBL19 (NCT04779398)
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Macular Degenerative Disease
A Safety Surveillance Study in Subjects With Macular Degenerative Disease Treated With Human Embryonic Stem Cell-derived Retinal Pigment Epithelial Cell Therapy
The purpose of this study is to is to evaluate the occurrence of late onset (i.e., greater than 5 years after treatment) adverse events of special interest (AESI) in participants who have received sub-retinal transplant of human…
- Trial name
- NCT03167203
- Testing
- Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Astellas Institute for Regenerative Medicine
Age Related Macular Degeneration
Ranibizumab In Pigment Epithelium Tears Secondary To Age-Related Macular Degeneration Study
The Ranibizumab in Pigment Epithelium Tears Secondary To Age-Related Macular Degeneration (RIP) Study is a prospective, multicenter, uncontrolled, interventional phase 2 clinical trial that investigates the effect of fixed…
- Trial name
- RIP (NCT01914159)
- Testing
- Ranibizumab (Lucentis, Novartis Pharma GmbH, Germany)
- Where
- 3 sites in Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bonn
Macular Edema, Central Serous Chorioretinopathy
Selective Retinal Pigment Epithelium Laser Therapy for Macular Disease of the Retina
Laser photocoagulation of the retina targeting the outer layers is an established therapy for proliferative retinopathy and macular edema from diabetic microangiopathy or retinal vein occlusion, centrals serous retinopathy, and…
- Conditions
- Macular Edema, Central Serous Chorioretinopathy, Retinal Vein Occlusion, Age-related Macular Degeneration
- Trial name
- NCT02088151
- Testing
- Selective retinal pigment epithelium laser therapy using the R:GEN Laser System
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Macular Teleangiectasia, Macular Pigment
MPOD in Macular Teleangiectasia Following Supplementation of Lutein and Zeaxanthin
Earlier investigations have detected low levels of macular pigment (MP) in the center of the fovea and a halo of MP at a higher eccentricity in persons with type 2 idiopathic juxtafoveal teleangiectasia (MACTEL)[Helb H-M, Charbel…
- Trial name
- MacTEL-Supp (NCT00568828)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- The Lowy Medical Research Institute Limited
Low Vision, Retinitis Pigmentosa
Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision
Purpose: To validate a newly developed battery of performance-based tests of visual function to be presented using virtual reality.
- Conditions
- Low Vision, Retinitis Pigmentosa, Stargardt Disease 1, Stargardt Disease 3
- Trial name
- NCT04281732
- Testing
- Virtual Reality Headset based tests
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen's University, Belfast
Macular Degeneration
Safety and Efficacy of Autologous Transplantation of iPSC-RPE in the Treatment of Macular Degeneration
This project intends to perform autologous transplantation of induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE).
- Trial name
- NCT05445063
- Testing
- Autologous iPSC-derived RPE
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tongren Hospital
Exudative Age-related Macular Degeneration
Macular Pigment Density Evolution in Unilateral Wet AMD Versus Non AMD Patients With or Without Lutein and Zeaxanthine Supplementation
•Purpose: Age-related Macular Degeneration ( AMD) is the leading cause of blindness and visual impairment in industrialized countries.
- Trial name
- NCT01404845
- Testing
- Nutrof Total, food supplement without Lutein and Zeaxanthin
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Affordance
Macular Pigment Optical Density
The Effect of Gojiberry Intake (Lycium Barbarium) on Macular Function
Objective: To evaluate the effects of goji berry intake for three months on macular pigment ocular density (MPOD) between 45 and 65 years old.
- Trial name
- NCT03983525
- Testing
- Goji berry, Lutein + zeaxanthin supplementation
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitiligo
Efficacy and Safety of ACH24 in the Treatment of Vitiligo
This is a multicenter clinical trial, phase III, randomized, placebo-controlled, parallel group, enroll 94 patients, to assess the efficacy of ACH24 in the repigmentation of achromatic areas in patients with vitiligo.
- Trial name
- NCT01419964
- Testing
- Group 01, Group 02
- Where
- Brazil
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.