Clinical trials: Maculopathy
Diabetic Maculopathy
Non-Responsive Diabetic Macular Edema and Spironolactone
Diabetic patients with macular edema and choroidal hyperpermeability (as manifested as a thick choroid on OCT (optical coherence tomography) and ICG hyperfluorescence on ICG) unresponsive to anti-VEGF (vascular endothelial growth…
- Trial name
- NCT04853355
- Testing
- Spironolactone 50 mg
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Age-Related Maculopathy, Age-Related Maculopathies
Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy
The purpose of this study is to determine the safety and tolerability of multiple doses of RN6G in subjects with advanced dry, age-related macular degeneration including geographic atrophy.
- Conditions
- Age-Related Maculopathy, Age-Related Maculopathies, Eye Diseases, Retinal Degeneration
- Trial name
- NCT01003691
- Testing
- RN6G
- Where
- 24 sites in United States
- Volunteers
- 24 people
- Sponsor
- Pfizer
Toxicity, Drug, Maculopathy
Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials
Maculopathy induced by retinal toxicity of synthetic antimalarials is to be screened at the sub-clinical stage. Indeed, when the first visual symptoms appear, macular damage is already irreversible and the clinical picture may…
- Trial name
- PERFOCTAPS (NCT02719002)
- Testing
- spectral domain optical coherence tomography C-scan and multifocal electroretinogram
- Where
- France
- Volunteers
- 109 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Retinitis Pigmentosa, Maculopathy, Age Related
Bimodal and Coaxial High Resolution Ophtalmic Imaging
The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- AOSLO-OCT (NCT04620876)
- Testing
- Bimodal high resolution imaging of the retina
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Age-Related Maculopathy, Choroidal Neovascularization
Reduced Fluence Photodynamic Therapy (PDT) With Visudyne in Combination With Lucentis for Age-Related Macular Degeneration
In this pilot study the researchers will evaluate the safety and efficacy of 50% reduced fluence PDT combination therapy with ranibizumab.
- Trial name
- NCT00473642
- Testing
- Ranibizumab, Verteporfin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Radiation Maculopathy
Evaluation of Retinal and Vascular Features in Radiation Maculopathy After Intravitreal Injections of Ranibizumab
This study evaluates the retinal and vascular features in patients with radiation maculopathy under the effects of Ranibizumab intravitreal injections using optical coherence tomography and optical coherence tomography…
- Trial name
- NCT04377295
- Testing
- Ranibizumab 0.5Mg/0.05Ml Oph Inj
- Volunteers
- 40 people
- Sponsor
- Federico II University
Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes
Anterior Corneal Striae in Hypotony
The goal of this is to evaluate the biomechanical properties of hypotonous eyes with vertical anterior corneal striae and/or hypotony maculopathy compared to hypotonous eyes without striae.
- Conditions
- Hypotony Ocular, Cornea Folds and Rupture of Bowman's Membrane Both Eyes, Maculopathy
- Trial name
- NCT04023123
- Testing
- Ophthalmic imaging
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopic Traction Maculopathy, Pars Plana Vitrectomy
Vitrectomy With Internal Limiting Membrane Peeling for Myopic Traction Maculopathy
Investigate the effectiveness and safety of pars plans vitrectomy, with internal limiting membrane peeling for cases of myopic traction maculopathy
- Conditions
- Myopic Traction Maculopathy, Pars Plana Vitrectomy, Internal Limiting Membrane Peeling
- Trial name
- NCT04278079
- Testing
- Pars Plana Vitrectomy with Internal Limiting Membrane peel
- Volunteers
- 52 people
- Sponsor
- Tanta University
Diabetic Macular Edema, Ischemic Maculopathy
Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA
Anti-vascular endothelial growth factor (VEGF) drugs are the mainstay of therapy for diabetic macular edema (DME), substantially improving visual acuity for many diabetics worldwide, and proving effective for treatment of both…
- Trial name
- IMPACT (NCT03246152)
- Testing
- Bevacizumab
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Cairo University
Deep Retinal Capillary Ischemia, Paracentral Acute Middle Maculopathy
Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet- Rich Plasma
To investigate the efficacy of retinal electromagnetic stimulation and sub-tenon autologous platelet rich plasma in the treatment of deep retinal capillary ischemia.
- Conditions
- Deep Retinal Capillary Ischemia, Paracentral Acute Middle Maculopathy, Acute Macular Neuroretinopathy
- Trial name
- rEMS (NCT04242719)
- Testing
- Electromagnetic stimulation, Platelet rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ankara Universitesi Teknokent
Retinal Disease, Diabetic Retinopathy
Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia
Vitreoretinal surgery has evolved to less invasive procedures, and it is used to treat a wide range of diseases. So anesthesia for vitreoretinal procedures has evolved, promoting adequate analgesia while reducing risks to the…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Maculopathy
- Trial name
- NCT03902925
- Testing
- Topical lidocaine 2% jelly plus sub-tenon ropivacaine 10% injection, Peribulbar injection
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution Retina Imaging
To increase the clinical experience of using the rtx1 camera in various retinal disorders and to follow the evolution of structural alterations during retinal diseases using adaptive optics imaging with the rtx1 camera
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IHR (NCT04128150)
- Where
- 3 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Macular Edema, Cystoid Macular Edema
Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma
To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex) and compare it with safety and efficacy of intravitreal bevacizumab in eyes with macular edema after plaque radiotherapy of uveal melanoma.
- Conditions
- Macular Edema, Cystoid Macular Edema, Uveal Melanoma, Radiation Maculopathy
- Trial name
- NCT01471054
- Testing
- Ozurdex, Bevacizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arman Mashayekhi
Choroidal Neovascularization, Age-Related Maculopathy
Safety and Efficacy of a New Treatment as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) Treatment in Patients With Age-Related Macular Degeneration (AMD)
The study will evaluate the safety and efficacy of the intravitreal implant of dexamethasone with Anti-VEGF treatment vs. Anti-VEGF alone (with sham dexamethasone injection) in patients with subfoveal choroidal neovascularization…
- Trial name
- NCT00511706
- Testing
- dexamethasone, ranibizumab
- Where
- 9 sites in United States, Australia and 7 more
- Volunteers
- 243 people
- Sponsor
- Allergan
Diabetic Maculopathy, Age Related Macular Degeneration
Reading Analysis in Ophthalmologic Patients
Investigation of the reading parameters and fixation behavior in patients with different ocular diseases (age-related macular degeneration, glaucoma, diabetic maculopathy, epiretinal membrane) and healthy subjects.
- Conditions
- Diabetic Maculopathy, Age Related Macular Degeneration, Glaucoma, Epiretinal Membrane
- Trial name
- NCT03750149
- Testing
- EyeTracker
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Diabetes Mellitus Type 1, Diabetic Maculopathy
Diameter Changes of Retinal Vessels During Hypoxia
The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
- Trial name
- NCT01689090
- Testing
- COX inhibitor, L-NG-monomethyl arginine citrate, COX inhibitor + L-NG-monomethyl arginine citrate
- Where
- Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Macular Degeneration, Age-Related Maculopathies
Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD)
This Phase 1 clinical research study will examine the safety and tolerability of an experimental gene transfer agent, AAV2-sFLT01, in patients with Neovascular Age-Related Macular Degeneration (AMD).
- Conditions
- Macular Degeneration, Age-Related Maculopathies, Age-Related Maculopathy, Maculopathies, Age-Related
- Trial name
- NCT01024998
- Testing
- AAV2-sFLT01
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Genzyme, a Sanofi Company
Diabetic Retinopathy, Visual Impairment
Shanghai Beixinjing Diabetic Eyes Study
In industrialized nations diabetic retinopathy(DR) is the most frequent microvascular complication of type 2 diabetes mellitus and the leading cause of visual impairment and blindness in the working-age population.
- Conditions
- Diabetic Retinopathy, Visual Impairment, Diabetic Maculopathy
- Trial name
- SBDES (NCT03571217)
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Age Related Maculopathy
The Role of Macular Pigment in Patients With Age-related Macular Degeneration
In the industrialised world age-related macular degeneration (ARMD) is the leading cause for legal blindness beyond the age of 50 years.
- Trial name
- NCT00494325
- Where
- Switzerland
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Maculopathy
Research of Automated Maculopathy Screening Based on AI Techniques Using OCT Images
The investigators expect to develop an algorithm that can interpret OCT images and automated determine whether the macula is normal or not by using OCT image-based deep learning techniques.
- Trial name
- NCT03476291
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University