Clinical trials: Magnesium Sulphate
Severe Sepsis, Septic Shock
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations.
- Trial name
- NCT01332734
- Testing
- Magnesium Sulfate
- Where
- Lithuania
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Myofascial Pain Dysfunction Syndrome
Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG.
Two groups of patients diagnosed with Myofascial Pain Dysfunction Syndrome (MPDS) will be included in this study. One group will receive trigger point injections of lidocaine alone.
- Trial name
- NCT07390851
- Testing
- Lidocaine 2% (preservative-free, without vasoconstrictor), Lidocaine 2% + Magnesium Sulfate 10% (combination)
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Chronic Pain
Trans-foraminal Lumbar Epidural Injection of Dexmedetomidine Against Magnesium Sulfate When Combined With Dexamethasone in Uni-lateral Lower Limb Radicular Pain. Multi-centeric Comparative Study
Transforaminal injection of chronic radicular lower limb injection by either dexmedetomdine or magnesuim sulfate
- Trial name
- NCT05271721
- Testing
- epidural transforaminal injection of magnesuim sulfate, epidural transforaminal injection of dexmedtemodine, transforaminal epidural injection of dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Postoperative Pain
Analgesic Efficacy of the Erector Spinae Plane Block Using Bupivacaine Versus Bupivacaine/Magnesium Sulphate in Patients Undergoing Lumbar Spine Surgery
Introduction: Severe postoperative pain following spine surgery is a significant cause of morbidity, extended length of facility stay, and marked opioid usage The analgesic regime for postoperative pain usually includes…
- Trial name
- NCT04433624
- Testing
- Group (B)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Postoperative Pain, Thoracic Surgery
Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
Thoracic surgery often produces severe postoperative pain due to nerve injury and inflammation. Effective pain control is essential to reduce complications and opioid use.
- Conditions
- Postoperative Pain, Thoracic Surgery, Multimodal Analgesia, Opioid Consumption, Postoperative
- Trial name
- LKM-Thorax (NCT07359469)
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Universidad Pública de Navarra
HIE - Hypoxic - Ischemic Encephalopathy
COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHLOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE
COMPARISON OF OUTCOME OF HYPOXIC ISCHEMIC ENCEPHALOPATHY MANAGED WITH COMBINATION OF MAGNESIUM SULPHATE AND MELATONIN VERSUS MAGNESIUM SULPHATE ALONE Participants of group A will have 3 doses of MgSO4 infusion at rate of 250mg/kg…
- Trial name
- NCT07652801
- Testing
- MgSO4 (seizure prevention), Melatonin , Mgso4
- Volunteers
- 80 people
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Premature Birth, Premature Labor
Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor
Primary Hypothesis: Acute tocolysis (48 hours) using oral nifedipine is more effective than intravenous magnesium sulfate in prolonging pregnancy in women with preterm labor with intact membranes between 24 and 32 6/7 weeks'…
- Trial name
- NCT00306462
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cough Suppression
Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery
Functional Endoscopic Sinus Surgery (FESS) is a widely performed procedure for the management of chronic rhinosinusitis and nasal polyposis.
- Trial name
- NCT07213037
- Testing
- Dexmedetomidine, Magnesium sulfate, lidocaine
- Volunteers
- 102 people
- Sponsor
- Assiut University
Primary Dysmenorrhea
Effect of a Magnesium Sulfate Footbath on Primary Dysmenorrhea Pain
Primary dysmenorrhea is a common condition characterized by painful menstruation. This three-arm randomized controlled trial evaluated the effect of a warm-water footbath containing magnesium sulfate on primary dysmenorrhea pain.
- Trial name
- NCT07726264
- Testing
- Magnesium Sulfate Warm-Water Footbath, Warm-Water Footbath
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kocaeli University
Colonic Adenoma, Bowel Preparation
Efficacy of Split-dose of Oral MMS for Bowel Preparation in Elderly Patients
Adequate bowel preparation is critical for successful colonoscopy and a large volume of PEG was required for bowel preparation in patients undergoing colonoscopy.
- Trial name
- NCT04948567
- Testing
- split-dose of Magnesium Sulfate solution, split-dose of PEG
- Where
- 2 sites in China
- Volunteers
- 1,174 people
- Sponsor
- Air Force Military Medical University, China
Effect of Drug
Comparative Effect of Transforaminal Injection of Magnesium Sulphate Versus Ozone Therapy on Oxidative Stress Biomarkers in Lumbar Disc Related Radicular Pain
Chronic lumbar radicular (CLR) pain is a term used to describe neuropathic pain symptoms in the distribution of a particular lumbar nerve root due to disc protrusion, spinal stenosis, facet hypertrophy, or fibrosis after previous…
- Trial name
- NCT04562493
- Testing
- Transforaminal Epidural injection
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Conscious Sedation
Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
The investigators hypothesize that magnesium sulphate owing to its analgesic and sedative properties is not inferior to fentanyl in providing conscious sedation as adjuvants to propofol and local injection of lidocaine in…
- Trial name
- CSDH (NCT03548493)
- Testing
- Magnesium sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Kasr El Aini Hospital
Opioid Consumption, Multimodal Analgesia
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the…
- Conditions
- Opioid Consumption, Multimodal Analgesia, Acute Appendicitis, Complication of Treatment
- Trial name
- NCT06563349
- Testing
- Intravenous magnesium sulfate, Normal saline infusion
- Where
- Poland
- Volunteers
- 188 people
- Sponsor
- Medical University of Warsaw
Postoperative Pain
Effect of Intraperitoneal Nebulisation of Magnesium Sulphate for Analgesia Following Laparoscopic Cholecystectomy
intraperitoneal nebulisation with magnesuim sulphate will reduce post operative pain and analgesic consumption in postoperative period following laparoscopic cholecystectomy.
- Trial name
- NCT01542697
- Testing
- intraperitoneal nebulisation of magnesium sulphate
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Lung Diseases
Adverse Events With Magnesium Sulfate
To investigate in pregnant women the adverse pulmonary effects of magnesium sulfate (MgSO4), a commonly used drug for tocolysis or arrest of labor.
- Trial name
- NCT00005448
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rest Cramps
Exploring the Role of Magnesium in Rest Cramps
This study sets out to show whether infusions of magnesium can lessen the frequency of rest cramps and to determine whether rest cramp sufferers have a deficiency in magnesium.
- Trial name
- NCT00423540
- Testing
- Intravenous Infusion of Magnesium Sulfate
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Analgesia, Pain, Postoperative
Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery
The rationale for multimodal analgesia is to achieve additive or synergistic analgesic properties while decreasing the incidence of side effects by reducing the dose of each agent.
- Conditions
- Analgesia, Pain, Postoperative, Spinal Stenosis, Spinal Disease
- Trial name
- NCT04391855
- Testing
- Tramadol with ropivacaine, Dexmedetomidine with ropivacaine, Magnesium with ropivacaine
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac; Dysrhythmia, Postoperative, Congenital Heart Surgery
Prevention of Post-Operative Cardiac Arrhythmias
Aim 1: Primary Prevention of Post-operative Cardiac Arrhythmias 1. To evaluate the efficacy of dexmedetomidine vs. the combination of Magnesium Sulfate and dexmedetomidine for the prevention of post-operative cardiac arrhythmias…
- Trial name
- POCA (NCT04234906)
- Testing
- Dexmedetomidine, Magnesium Sulfate, Amiodarone
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- Jeffrey Moak
Fetal Neuroprotection
Magnesium Sulfate (MgSO4) and Fetal Heart Rate (FHR) in Case of Prematurity
Type of study: prospective descriptive monocentric study Population: 2 groups: -Exposed group: pregnant patient between 24AW+0day and 32AW+0day receiving magnesium sulfate for fetal neuroprotection in the doubt of premature…
- Trial name
- NCT03956121
- Testing
- injection of magnesium sulfate
- Where
- France
- Volunteers
- 57 people
- Sponsor
- CHU de Reims
Labor, Premature
Tocolytics Trial: Intravenous (IV) Magnesium Versus Oral Nifedpine in Fetal Fibronectin (FFN) Postive Population
In women with singleton gestations, to contemporarily assess the efficacy of oral nifedipine versus intravenous magnesium sulfate in the acute management of preterm labor in terms of defined early and late neonatal measures
- Trial name
- NCT00641784
- Testing
- Magnesium, Nifedlipine
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- MemorialCare