Clinical trials: Magnetic Resonance Imaging (MRI)
Mild Traumatic Brain Injury
Acute and Mild TBI Injury in Military and Civilian Population Using Advanced MR Imaging
This is a prospective longitudinal study of patients with acute mTBI and comparison with chronic mTBI patients and a cohort without history of TBI or none within 5 years of enrollment.
- Trial name
- NCT05101239
- Testing
- MRI imaging exam
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
Breast Cancer
TPI 287 in Breast Cancer Metastatic to the Brain
The goal of the first part of this clinical research study is to find the highest tolerable dose of TPI-287 in patients with breast cancer that has spread to the brain.
- Trial name
- NCT01332630
- Testing
- TPI 287, Dexamethasone, Benadryl
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Female, Doxorubicin Induced Cardiomyopathy
Doxorubicin-associated Cardiac Remodeling Followed by CMR in Breast Cancer Patients
Twenty-seven breast cancer women without heart failure, underwent CMR imaging (3T-Achieva, Philips) before and 3 times serially after 4-cycles of adjuvant DOX (60mg/m2).
- Trial name
- NCT03000036
- Testing
- Doxorubicin, Achieva, Philips Medical Systems (3T magnet), Gadoterate Meglumine
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- University of Campinas, Brazil
Central Nervous System Disease, Central Nervous System Neoplasms
Retrospective Study of MRI in Pediatric Patients
Collection of already existing data and images for patients < 2 years of age having MultiHance administration for a MRI of the brain or spine.
- Trial name
- NCT02291822
- Testing
- Gadobenate Dimeglumine
- Volunteers
- 90 people
- Sponsor
- Bracco Diagnostics, Inc
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
COPD (Chronic Obstructive Pulmonary Disease)
Airway Dysfunction, Occlusions and Remodeling: COPD Patients and Mepolizumab
The goal of this study is to evaluate the effect of mepolizumab on patients with COPD using MRI and CT imaging as well as breathing tests.
- Trial name
- ADORE (NCT07749001)
- Testing
- Mepolizumab 100 MG Injection
- Volunteers
- 36 people
- Sponsor
- Western University, Canada
Foetal Differences Between Healthy and Schizophernic Parents
Schizophrenia Imaging
Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia.
- Trial name
- NCT01655472
- Testing
- imaging follow up: MRI scan, imaging follow up: Ultrasonographic examination
- Where
- 8 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neuralgia
Ketamine and fMRI for Neuropathic Pain
Neuropathic or nerve injury related pain (NP), an extremely unpleasant condition that is difficult to treat, often has a severe, persistent, and unremitting course. Conventional treatments are often ineffective in relieving NP.
- Trial name
- NCT02373449
- Testing
- RS-fMRI, Ketamine
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- University Health Network, Toronto
Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
Liver Disease in Urea Cycle Disorders
This is a multi-center, cross-sectional study to assess risk for liver fibrosis and hepatic injury in individuals with urea cycle disorders (UCDs) using serum biomarkers, Fibroscan, and MRE.
- Conditions
- Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency, Citrullinemia 1, ARGI Deficiency
- Trial name
- NCT04612764
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Baylor College of Medicine
Major Depressive Disorder
Vagus Nerve Stimulation: Integration of Behavior and Cardiac Modulation
This study characterized the impact of respiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry, vagal tone and depressed mood in patients with major depressive disorder…
- Trial name
- tVNS-MDD (NCT04467164)
- Testing
- exhalatory-gated transcutaneous vagus nerve stimulation (e-RAVANS), Inhalatory-gated transcutaneous vagus nerve stimulation (i-RAVANS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis
Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA)
Phase IIIb study to determine early response to Certolizumab Pegol (CZP) with Magnetic Resonance Imaging (MRI) score Outcome Measures in Rheumatoid Arthritis (RA) Clinical Trials (OMERACT) RA MRI Scoring System (RAMRIS) in…
- Trial name
- MARVELOUS (NCT01235598)
- Testing
- Certolizumab Pegol (CZP) 200 mg, Certolizumab Pegol (CZP) 400 mg
- Where
- 10 sites in Denmark, Netherlands and 2 more
- Volunteers
- 41 people
- Sponsor
- UCB Pharma
Atherosclerosis, Peripheral Vascular Disease
Magnetic Resonance Imaging to Detect Blood Vessel Inflammation in Patients Undergoing Peripheral Balloon Angioplasty
This study will examine the use of magnetic resonance imaging (MRI) in detecting blood vessel inflammation. The results of this study may later be applied to diagnosing inflammation of arteries in patients with atherosclerosis…
- Trial name
- NCT00004549
- Testing
- Magnetic resonance imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rectal Neoplasms, Magnetic Resonance Imaging
Diagnostic Value of Novel MR Imaging Techniques for the Primary Staging and Restaging of Rectal Cancer
The purpose of this study is to determine the clinical value of the novel MRI-techniques DWI and gadofosveset-enhanced MRI for the management of rectal cancer patients.
- Conditions
- Rectal Neoplasms, Magnetic Resonance Imaging, Neoplasms Staging
- Trial name
- NCT01721785
- Testing
- GADOFOSVESET TRISODIUM 244 Mg in 1 mL INTRAVENOUS INJECTION, SOLUTION [Ablavar]
- Where
- 10 sites in Netherlands
- Volunteers
- 307 people
- Sponsor
- Maastricht University Medical Center
Brain Tumor
Multihance at 3 Tesla (3T) in Brain Tumors
Compare the efficacy of MultiHance and Magnevist
- Trial name
- NCT00395863
- Testing
- Multihance, Arm 2 - Magnevist
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Bracco Diagnostics, Inc
Pharmacokinetics, Magnetic Resonance Imaging
Oral Pharmacokinetics of Sulfasalazine, Paracetamol, Fexofenadine and Valsartan Using Different Administration Mediums
The purpose of this study is to determine pharmacokinetics of the probe-drugs sulfasalazine, given in 240 ml non-caloric water and paracetamol, fexofenadine and valsartan after oral administration, given in 240 ml non-caloric…
- Conditions
- Pharmacokinetics, Magnetic Resonance Imaging, Administration, Oral
- Trial name
- NCT03012763
- Testing
- Paracetamol, Sulfasalazine, Fexofenadine
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Alzheimer's Disease
Study of Memantine in Assessment of Selected Measures of Volumetric Magnetic Resonance Imaging (MRI) and Cognition in Moderate AD (Alzheimer's Disease)
The purpose of this study is to characterize the progression of disease using volumetric MRI techniques and cognitive outcome measures in patients with moderate dementia of the Alzheimer's type treated with open-label memantine.
- Trial name
- NCT00334906
- Testing
- memantine HCl
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Forest Laboratories
Peripheral Arterial Disease, Intermittent Claudication
Non-Contrast Enhanced Peripheral Magnetic Resonance Angiography
To systematically develop, test, and refine peripheral vascular electrocardiography-gated fast spin echo magnetic resonance imaging for the accurate diagnosis of peripheral arterial disease without gadolinium contrast.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Peripheral Vascular Disease
- Trial name
- NCT02823444
- Testing
- Magnetic Resonance Angiography
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Utah
Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder
Neurologic Injuries in Adults With Urea Cycle Disorders
Urea cycle disorders (UCDs) are a group of rare inherited metabolism disorders. The purpose of this study is to evaluate how UCD-related neurologic injuries affect adults with one of the most common types of UCD.
- Conditions
- Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
- Trial name
- NCT00472732
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Andrea Gropman
Nasopharyngeal Carcinoma
Combining MRI and CEUS to Diagnose Small Cervical Lymph Node Metastases in NPC Patients
This is a single-center diagnostic accuracy study, with the purpose to define the criteria to diagnose small cervical lymph node metastases in patients with nasopharyngeal carcinoma by combining MRI scanning and contrast-enhanced…
- Trial name
- NPC-LN (NCT05389306)
- Testing
- MRI Scanning, Contrast-Enhanced Ultrasonography, Ultrasound-guided Lymph Node Aspiration
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Sun Yat-sen University
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