Clinical trials: Magnetic Resonance Imaging Contrast Agents
Non-enhancing Cerebral Gliomas
Intraoperative Sonographically Guided Resection of Non-enhancing Gliomas
The purpose of the study is to determine whether intraoperative ultrasound guided resection of glioma without contrast enhancement in magnetic resonance imaging can achieve higher extent of resection than surgery without…
- Trial name
- SONOGLIO (NCT05470374)
- Testing
- Intraoperative sonography
- Where
- Russia
- Volunteers
- 96 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Myocardial Infarction, Angina, Unstable
Using Magnetic Resonance Imaging to Evaluate Heart Vessel Function After Angioplasty or Stent Placement Procedures
Coronary artery disease (CAD) is caused by a narrowing of the blood vessels that supply blood and oxygen to the heart. Balloon angioplasty and stent placement are two treatment options for people with reduced heart function…
- Conditions
- Myocardial Infarction, Angina, Unstable, Cardiomyopathy, Hypertrophic
- Trial name
- NCT00692991
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Johns Hopkins University
Perforator Flap Surgery
Comprehensive Imaging of Perforator Vessels and Subcutaneous Vascular Network With No-Exogenous Contrast and Non-Ionizing-Radiation Magnetic Resonance Angiography
In this study the investigators plan to enroll a total of 25 evaluable volunteers (volunteer population) for the development and optimization of perforator imaging protocols and 50 evaluable clinical patients receiving flap…
- Trial name
- NCT03567018
- Testing
- MRI Scan
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Fibrosis and Cirrhosis of Liver
Quantitative MRI Imaging in Diffuse Liver Diseases
As we all know, the early diagnosis and accurate staging of liver fibrosis are very important to reduce the incidence of liver cirrhosis and liver cancer.
- Trial name
- QMIDLD (NCT04626492)
- Testing
- Quantitative MRI imaging
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Breast Cancer
Contrast-enhanced MR Imaging as a Breast Cancer Screening in Women at Intermediate Risk
A multicenter randomized controlled trial to evaluate the performance of MRI, in terms of sensitivity, specificity, and predictive value, in the screening of women at intermediate risk of breast cancer.
- Trial name
- MRIB (NCT02210546)
- Testing
- Magnetic Resonance Imaging (MRI), Mammography (Mx) + ultrasonography (US)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Prof. Paolo Bruzzi
Healthy
Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols
One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is…
- Trial name
- CMR-TECH (NCT01728597)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Obstructive Coronary Artery Disease, Coronary Arteriosclerosis
Gadofosveset Trisodium for Heart Imaging Studies
Background: Magnetic resonance imaging (MRI) is type of imaging study that uses magnetic fields and radio waves to take pictures of the body. To help the images show up more clearly, a contrast agent is injected into a vein.
- Conditions
- Obstructive Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Artery Disease (CAD)
- Trial name
- NCT01853592
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Diabetes, Magnetic Resonance Imaging
Cardiovascular Contrast-enhanced Magnetic Resonance Imaging Using Polysaccharide Superparamagnetic Iron Oxide Injection in Diabetic Patients
This is an open-label, single-center, single-dose study aims to evaluate the effect and safety of polymeric superparamagnetic iron oxide in cardiovascular magnetic resonance imaging for diabetic patients with concomitant chronic…
- Trial name
- NCT06051565
- Testing
- Polysaccharide superparamagnetic iron oxide injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Bone Tumor, Soft Tissue Tumor
Osteoarticular Tumor Characterization by Advanced Imaging
The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which…
- Trial name
- TUMOSTEO (NCT02895633)
- Testing
- Ecography, CT scan, MRI
- Where
- France
- Volunteers
- 1,090 people
- Sponsor
- Central Hospital, Nancy, France
Healthy
First in Human Study of RVP-001, a New Manganese Based MRI Contrast Agent
The objectives of this trial are: 1. To evaluate the safety and tolerability of single ascending doses of RVP-001 in healthy adult volunteers 2.
- Trial name
- NCT05413668
- Testing
- RVP-001
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Reveal Pharmaceuticals Inc.
Healthy Aortic Blood Flow
Quantifying Blood Flow in the Aorta
This study aims to gain insights into aortic blood flow in healthy volunteers using PC 4D-flow MRI
- Trial name
- AF-4DMRI-P2 (NCT07577752)
- Testing
- 4D-flow Magnetic Resonance Imaging, Questionnaires
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Twente
Brain Tumor, Primary
Intra-operative Variation in Size of Brain Tumors After Craniotomy
We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.
- Trial name
- NCT04365647
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Crohn Disease, Ultrasound Therapy; Complications
Correlation of Cross Sectional Imaging and Small Intestinal Contrast Ultrasonography in Known Crohn's Disease
Small intestinal contrast ultrasound (SICUS) is a modality of intestinal ultrasound (IUS) which does not require any parenteral administration of contrast agent but requires ingestion of around 500 ml of polyethylene glycol…
- Conditions
- Crohn Disease, Ultrasound Therapy; Complications, Computed Tomography, Magnetic Resonance Imaging
- Trial name
- CACTUS-CD (NCT06125678)
- Testing
- Small intestinal contrast enhanced ultrasound followed by Computed tomography/Magnetic resonance enterography
- Where
- India
- Volunteers
- 407 people
- Sponsor
- Asian Institute of Gastroenterology, India
Magnetic Resonance Imaging
Kinetics of Urinary Excretion of Gadolinium Contrast Agents Used in MRI Examinations
This is a single-center cohort study aimed to describe the urinary excretion kinetics of gadolinium contrast agents (Gd-CAs). Patients with a prescription for injected MRI are invited to participate in the study.
- Trial name
- GADODURABLE (NCT06191731)
- Testing
- biological samples collection
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
For Contrast-enhanced Magnetic Resonance Imaging (MRI) of Abnormal Vascular Lesions in Body Regions Excluding the Central Nervous System (CNS)
A Study of a Gadolinium-Based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Body Parts (Non-Central Nervous System) Lesions
The purpose of this study is to evaluate the efficacy of HRS-9231 for Magnetic Resonance Imaging (MRI) of body regions excluding the Central Nervous System (CNS) in patients undergoing MRI examinations, using the patient's own…
- Trial name
- NCT07275723
- Testing
- HRS-9231 Injection, Gadobutrol Injection, Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in China
- Volunteers
- 309 people
- Sponsor
- Shanghai Shengdi Pharmaceutical Co., Ltd
Breast Cancer
Screening Contrast-enhanced Mammography
The main objective of this study is to compare the diagnostic performance of two diagnostic methods, namely CESM and MRI, in the evaluation of a lesion suspicious of breast cancer in 300 Quebec women referred for the…
- Trial name
- NCT05390229
- Where
- Canada
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Contrast-induced Nephropathy, Coronary Angiography
Using Preprocedural Urine NMR(Nuclear Magnetic Resonance) -Based Metabolomics Analysis
The use of coronary intervention has increased over the last decade. Contrast induced nephropathy (CIN) that develops as a result of procedures using intravenous or intra arterial contrast enhancement, or other diagnostic…
- Trial name
- NCT03731962
- Testing
- Coronary Angiography
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Coronary Artery Disease
Identification of Adverse Plaque Characteristics by Coronary MR Angiography
This is a pilot study to determine whether coronary magnetic resonance angiography(CMRA)can identify adverse plaque characteristics (buildup of fat, cholesterol, calcium, and other substances found in the blood) seen on coronary…
- Trial name
- NCT01986868
- Testing
- Coronary MR Angiography (CMRA)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cedars-Sinai Medical Center
Intra-axial Tumors, Extra-axial Tumors
Evaluation of Gadolinium Based Contrast Agents for Portable MR Imaging Systems
This is a prospective, multi-center, interventional study designed to evaluate the visualization benefits of FDA approved gadolinium-based contrast agents (GBCAs) in portable magnetic resonance imaging (pMRI) of the brain.
- Conditions
- Intra-axial Tumors, Extra-axial Tumors, Infection/Inflammatory Lesions
- Trial name
- Contrast PMR (NCT07296263)
- Testing
- Portable MRI (pMRI), Gadolinium-Based Contrast Agent (GBCA)
- Where
- 6 sites in United States
- Volunteers
- 85 people
- Sponsor
- Hyperfine
End Stage Renal Disease, Renal Transplant Rejection
MRI in Renal Transplantation
Renal transplantation is the optimal method of treatment for end stage kidney disease however median lifespan of a kidney transplant is around 15 years.
- Conditions
- End Stage Renal Disease, Renal Transplant Rejection, Kidney Transplant Failure and Rejection, Chronic Kidney Diseases
- Trial name
- TransRASL (NCT03705091)
- Testing
- Magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde