Clinical trials: Magnetic Resonance Spectroscopy
Ovarian Cancer
Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology
Patients with known ovarian cancer will be imaged up to four times with FDG-PET, C13 MRI and other novel MRI techniques during their treatment course including: before the start of any treatment (with optional repeat scanning)…
- Trial name
- MISSION-ovary (NCT03526809)
- Testing
- MRI scan and FDG-PET scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Neoplasm Metastasis, Lung Neoplasms
Proton MR Spectroscopy of Brain Metastases in Evaluation of Treatment Response.
The aim of the study is to investigate the feasibility of in vivo single volume MR spectroscopy in evaluation of treatment response in patients with brain metastases, using 3T MR instrument.
- Conditions
- Neoplasm Metastasis, Lung Neoplasms, Breast Neoplasms, Melanoma
- Trial name
- NCT00184288
- Where
- Norway
- Sponsor
- Norwegian University of Science and Technology
Bipolar Depression
Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression
There have been reports that stimulants may be effective for bipolar depression without triggering mania. This study will examine whether lisdexamfetamine can improve depressive symptoms over the course of eight weeks.
- Trial name
- NCT01051440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Head and Neck Cancer, Pharynx Cancer
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer
Radiotherapy (RT) with concurrent chemotherapy represents the state of the art in curative intent treatment for locally advanced squamous carcinoma of the head and neck.
- Trial name
- NCT00140556
- Testing
- Chemoradiotherapy, Cisplatin, Bevacizumab
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- David M. Brizel, MD
Cancer
Lactate Imaging as a Tumour Biomarker
This project is designed to investigate whether measurements of lactate in tumours, made using a magnetic resonance technique similar to MRI, is an effective non-invasive method to detect whether some new targeted drugs are…
- Trial name
- NCT01881386
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Uterine Cervical Neoplasms
MR Metabolic Biomarkers for Cervical Cancer
The purposes of this study are: (1) to develop magnetic resonance (MR) imaging and spectroscopy as surrogate biomarkers for altered cancer metabolism in cervical cancer; (2) to understand the function of human papillomavirus…
- Trial name
- NCT01874548
- Where
- Taiwan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Multiple Sclerosis
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.
REPAIR-MS is a single-center open label, sequential group, investigator and patient blinded study to assess the CNS metabolic effects, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in patients who have been diagnosed…
- Trial name
- REPAIR-MS (NCT03993171)
- Testing
- gold nanocrystals
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Clene Nanomedicine
Major Depressive Disorder
Treatment Resistant Geriatric Depression in Primary Care
This study involves collaboration between McLean Hospital, Geriatric Medicine at the Cambridge Health Alliance (CHA) and other sites within the Partners and Harvard Medical School network.
- Trial name
- NCT01392287
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Neoplasm Metastases
Clinical MR Spectroscopy of Brain Metastases at 1,5T and 3T.
Increasing magnetic field is known to give improvements in signal-to-noise-ratio (SNR) and spectral resolution. To investigate this, spectra from different subjects were examined using two clinical MR instruments operating at…
- Trial name
- NCT00184353
- Where
- Norway
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Brain Tumor
Pilot Study Effect of Sulfasalazine on Glutamate Levels by(Magnetic Resonance Spectroscopy)MRS in Patients With Glioma
The main purpose of this part of the study is to determine the Central Nervous System bioavailability of sulfasalazine.
- Trial name
- NCT01577966
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Alabama at Birmingham
Bipolar Depression
CoQ10 in Geriatric Bipolar Depression
We propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. We would also like to investigate changes in brain energy metabolites and in vivo creatine kinase (CK)…
- Trial name
- CoQ10 (NCT00720369)
- Testing
- CoEnzyme Q10
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Brain Tumors
Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity
This study in children and young adults will compare two types of imaging, positron emission tomography ([(18)F]-DG PET) and proton magnetic resonance spectroscopy ((1)H-MRSI), to determine activity of a brain tumor or abnormal…
- Trial name
- NCT00067821
- Testing
- 2-Flourodeoxyglucose
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- National Cancer Institute (NCI)
Schizophrenia, Schizoaffective Disorder
Biomarker Study of Acamprosate in Schizophrenia
NMDA receptors are brain receptors that are stimulated by glutamate. Poorly functioning NMDA receptors are thought to be involved in the pathology of schizophrenia.
- Trial name
- NCT00688324
- Testing
- Acamprosate
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Maryland, Baltimore
Systemic Lupus Erythematosus, Fibromyalgia
Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus
The purpose of this study is to find out if certain types of Magnetic Resonance (MR) scanning will help to better detect markers in the brain that are related to the neuropsychiatric symptoms of systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Fibromyalgia, Acute Neuropsychiatric Lupus
- Trial name
- NCT00723671
- Testing
- MRI
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Thoracic Cancer, Left Sided Breast Cancer
Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Patients enrolled in the study will receive standard of care adjuvant or definitive breast, chest wall or thoracic radiation therapy.Cardiac mitochondrial dysfunction is a hallmark of radiation-induced cardiac injury.
- Trial name
- NCT04044872
- Testing
- [1-13C]pyruvate along with MRI imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Hypertension, Pulmonary Arterial Hypertension
129 Xenon Imaging in Patients Treated With Sotatercept
Determine the ability of 129Xe MRI/MRS biomarker signatures to non-invasively monitor pulmonary vascular reverse remodeling induced by sotatercept in pulmonary arterial hypertension (PAH).
- Trial name
- Sox-PH (NCT06351345)
- Testing
- 129Xe Hyperpolarized
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Bastiaan Driehuys
Prostate Adenocarcinoma, PSA Level Greater Than Ten
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Predicting Treatment Response in Patients With Prostate Cancer
This phase II trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance spectroscopic imaging works in predicting treatment response in patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, PSA Level Greater Than Ten, Stage IIB Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT03581500
- Testing
- Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Obsessive-Compulsive Disorder
Characterization of Childhood-Onset Obsessive-Compulsive Disorder
The purpose of this study is to learn more about Obsessive-compulsive Disorder (OCD) in children. OCD usually has a slow onset, and symptoms that may remain at a stable level over time.
- Trial name
- NCT00044239
- Where
- 4 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Autism Spectrum Disorder
Study of Neuroimaging Biomarkers of Social Cognition Deficits in Adolescents (Age 13-17) With Autism Spectrum Disorder and Effects of Gabapentin
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is increasing in prevalence, and is characterized by deficits in social communication and interaction across multiple contexts, and restricted, repetitive…
- Trial name
- NCT03589898
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Massachusetts, Worcester
Depression, Bipolar
Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression
This research is aimed to investigate the efficacy and safety of the creatine and cytidine augmentation in treating bipolar depression and to evaluate changes in relevant brain biochemical metabolism using proton and phosphorous…
- Trial name
- NCT02625779
- Testing
- Valproate and Cytidine-containing Drug, Valproate and Creatine-containing Drug
- Where
- South Korea
- Sponsor
- Ewha Womans University Mokdong Hospital