Clinical trials: Magnetic Resonance Spectroscopy Imaging
Healthy, Nervous System Disease
Functional and Metabolic Imaging Using Magnetic Resonance Imaging and Spectroscopy
Technical advances in magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have provided researchers with the opportunity to study changes of the central nervous system (CNS) and improve diagnosis and…
- Trial name
- NCT00001591
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Brain Mapping, Healthy Volunteer
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
Background: Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain.
- Trial name
- NCT01266577
- Testing
- NSR MAGNETOM 7T, 1Tx x 32Rx Head Coil
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Prostate Cancer
Magnetic Resonance (MR) Spectroscopy in Localized Prostate Cancer
This study is designed to investigate whether filling the rectum with high density barium prior to a magnetic resonance spectroscopy (MRS)exam of the prostate improves the quality of the acquired spectrum.
- Trial name
- NCT00756392
- Testing
- 3T MR Spectroscopy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- AHS Cancer Control Alberta
ADHD
A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
The proposed study is to test and validate a novel intervention that integrates computerized cognitive training with real-time neuromonitoring and neurofeedback to enhance working memory by probing the individualized neural…
- Trial name
- NCT04002167
- Testing
- Neurofeedback, Cognitive training
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
Traumatic Brain Injury, Mild Traumatic Brain Injury
Cerebrovascular Reactivity in American Football Players
Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after repetitive mild traumatic brain injury (rmTBI) as…
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03417492
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Breast Cancer
Quantitative Methods for Supplementing Contrast-Enhanced Magnetic Resonance Imaging of Breast Cancer
Contrast-enhanced magnetic resonance imaging (CE-MRI) is now established as the most accurate non-invasive imaging modality for characterizing breast cancer.
- Trial name
- NCT02058758
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anxiety, Depression
Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults.
This is a 12-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of sub-clinical anxiety and depression.
- Trial name
- NutriMOOD (NCT04844034)
- Testing
- High-EPA multinutrient supplement.
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Heart Diseases, Heart Failure
Fluid Status and T1-mapping by CMR
It is unclear to what extent systemic fluid overload has an impact on T1-mapping results by cardiovascular mangetic resonance imaging.
- Conditions
- Heart Diseases, Heart Failure, Valvular Heart Disease
- Trial name
- BCM-CMR-T1 (NCT03372512)
- Testing
- Bioimpedance spectroscopy
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Minimal Hepatic Encephalopathy
Study of Rifaximin in Minimal Hepatic Encephalopathy
Rifaximin therapy will improve brain functioning on MRI scanning and change the microbiome and metabolome.
- Trial name
- NCT01069133
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Autoimmune Encephalitis
Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis
Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody…
- Trial name
- DANCE-AE (NCT05280600)
- Testing
- Not applicable - non-interventional study
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy
UTSW HP [13-C] Pyruvate Injection in HCM
The study objective is to identify the earliest changes in energy substrate metabolism in patients with cardiomyopathies (CMP). To achieve this objective, we plan first to test the hypothesis that patients with CMP present focal…
- Conditions
- Cardiomyopathy, Hypertrophic, Dilated Cardiomyopathy, Duchenne Muscular Dystrophy, Cardiac Sarcoidosis
- Trial name
- HPHCM (NCT03057002)
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Brain Tumor, Glioma
Metabolic Characterization of Space Occupying Lesions of the Brain
High field MR-technologies are expected to boost metabolic spectroscopic imaging (MRSI), but also CEST-MRI. This is due to the fact that increased SNR is available which can be used to increase the spatial resolution of all…
- Conditions
- Brain Tumor, Glioma, IDH Mutation
- Trial name
- FASTMRSI (NCT04233788)
- Testing
- MR-scans using a 3T Prisma and a 7T Terra scanner (Siemens, Erlangen Germany)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Alzheimer's Disease
MRI to Measure Treatment With Antibiotics in Alzheimer's Disease
Objectives: To study the changes in brain structure and function using MRI scans in patients treated for Alzheimer's disease. Methods: A pilot study of treating Alzheimer's disease with antibiotics showed some promise that this…
- Trial name
- DARAD-MRI (NCT00692588)
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Malignant Glioma
Characterization of Serial Magnetic Resonance Spectroscopy Imaging in Patients With Malignant Glioma Undergoing Radiotherapy
Malignant glioma is the most common primary brain tumor in adults. Despite aggressive therapy, less than 40% of these patients are expected to live beyond 5 years.
- Trial name
- NCT00125697
- Testing
- 3T MRI Scanning
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- AHS Cancer Control Alberta
Opioid-Related Disorders, Alcohol-Related Disorders
Imaging Biomarker for Addiction Treatment Outcome
Background: Many people suffer from drug addiction. But currently, treatments are not very effective. One group of patients in this study are enrolled in addiction treatment through physician health programs (PHPs).
- Trial name
- NCT03427424
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Posterior Cortical Atrophy
Testing Personalized High-Definition Transcranial Direct Current Stimulation (HD-tDCS) as a Treatment of Posterior Cortical Atrophy
This study is being completed to learn if high-definition transcranial direct current stimulation (HD-tDCS) has an effect on visual and thinking abilities in persons with posterior cortical atrophy (PCA).
- Trial name
- PCA (NCT07191327)
- Testing
- HD-tDCS sessions, HD-tDCS sessions - Open-label (after randomized treatment)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Uterine Cervical Neoplasms
MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer
To detect differences in MR spectroscopy, diffusion weighted MR, diffusion tensor imaging (DTI) or dynamic contrast enhancement (DCE) MR imaging between primary cervical tumors and normal cervical tissue.
- Trial name
- MRI (NCT01060033)
- Testing
- MR Spectroscopy, Fat-Saturation and Diffusion-Weighted Imaging, Dynamic Contrast Enhancement MRI (MR-DCE)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine