Clinical trials: Magnetic Resonance Spectroscopy Imaging
Uterine Neoplasms
MRI and Metabolomics Biomarkers for Uterine Malignancy
The aims of this project are: (1) To establish a research platform in order to integrate multiparametric imaging and metabolomics data for uterine malignancy.
- Trial name
- EMCAMRS (NCT02528864)
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Alcohol-related Liver Disease, Metabolic Dysfunction Associated Steatotic Liver Disease
Investigating Myosteatosis in Steatotic Liver Diseases
Steatotic liver diseases (SLD) are the most common chronic liver diseases worldwide. SLD are defined by an excessive liver lipid content (steatosis) of more than 5% of the total liver weight and includes 3 clinical entities …
- Conditions
- Alcohol-related Liver Disease, Metabolic Dysfunction Associated Steatotic Liver Disease, Steatotic Liver Disease of Mixed Origin (MetALD), Steatotic Liver Diseases
- Trial name
- MYO-SLD (NCT06514300)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Obsessive Compulsive Disorder
Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD
This study will examine the feasibility and potential efficacy of augmenting SRIs with minocycline. The study will assess whether the addition of minocycline leads to measurable changes in striatal glutamate (Glu) levels.
- Trial name
- NCT01695291
- Testing
- Minocycline
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
Mild Cognitive Impairment, Older Adults at High Risk for MCI
The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI
The goal of this clinical trial is to learn about the effect of long resistance training intervention on brain and muscle health in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT06252844
- Testing
- Resistance exercise training, Active control
- Where
- 2 sites in Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Radiation Injury, Brain Tumor
Differentiating Recurrent Brain Tumor Versus Radiation Injury Using MRI
The purpose of this study is to determine if certain MRI imaging sequences (pictures) are more helpful to the physicians in determining if a brain tumor has recurred or if the person has radiation injury following their treatment.
- Trial name
- NCT00760409
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Michigan
Type1diabetes, Depressive Symptoms
Type 1 Diabetes and Depression: Role of Brain Glutamate
The goal of this study is to examine the effect of chronic and acute hyperglycemia in type 1 diabetes mellitus (T1DM) on brain glutamate levels using magnetic resonance spectroscopy (MRS), and associations of brain glutamate with…
- Conditions
- Type1diabetes, Depressive Symptoms, Major Depressive Disorder
- Trial name
- NCT05355285
- Testing
- Glucose Clamp
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Breast Cancer
Evaluation of Patients With Breast Cancer Using DCE-MRI, MRS, and Proteomics
RATIONALE: Diagnostic procedures, such as dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI), magnetic resonance spectroscopy (MRS), and tissue proteomics, may help doctors find and diagnose breast cancer and plan the…
- Trial name
- NCT00656604
- Testing
- proteomic profiling, lumpectomy or mastectomy, dynamic contrast-enhanced magnetic resonance imaging
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
First Episode Psychosis (FEP)
Dopamine and Insulin in Psychosis
Patients with schizophrenia have a high risk of developing metabolic disorders and current evidence points to an overlap in mechanisms underlying psychiatric symptoms and metabolic disturbances.
- Trial name
- DIPS (NCT07252752)
- Testing
- Intranasal Insulin, Low dose insulin infusion, [11C] (+)-4-propyl-(+)-4-propyl-9-hydroxynaphthoxazine (PHNO)
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pancreatic Cyst
Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection
To learn if Hyperpolarized C-Pyruvate Magnetic Resonance (HP-MR) Spectroscopic Imaging can help doctors detect low-risk (benign) and high-risk (malignant) cysts.
- Trial name
- NCT05873699
- Testing
- Hyperpolarized 13-C-pyruvate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Heart Failure With Preserved Ejection Fraction, Obesity
The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
This study looks at the effects of weight loss in people who have heart failure with preserved ejection fraction (HFpEF) and are overweight or obese.
- Trial name
- OWL-HFPEF (NCT05878912)
- Testing
- Diet intervention
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Oxford
Mood
The Effects of Cranial Electrotherapy Stimulation (CES) on Brain Function, Brain Chemistry and Mood
Document whether the Fischer Wallace Cranial Stimulator produces any measurable changes in brain activity.
- Trial name
- CES (NCT01860677)
- Testing
- Fisher Wallace Cranial Stimulator
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Obesity
Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus
This interventional study is part of a broader research project entitled "Bone Marrow Adipose Tissue in Relation to Bone and Energy Metabolism in Obesity and Type 2 Diabetes Mellitus." The broader project includes both a…
- Trial name
- BOD-BMAT (NCT07731438)
- Testing
- Caloric Restriction
- Where
- 3 sites in Czechia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- General University Hospital, Prague
Brain and Central Nervous System Tumors
Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI), (done before, during, and after treatment) may help doctors predict a patient's response to treatment…
- Trial name
- NCT00274755
- Testing
- chemotherapy, conventional surgery, magnetic resonance imaging
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Francisco
Breast Cancer
MRg-NIRS Imaging System Breast Cancer Trial
This trial is a study of 20 women with breast cancer to evaluate the addition of MR-guided (MRg) near-infrared spectroscopy (NIRS) with and without contrast, as part of a program to improve clinical management of women receiving…
- Trial name
- MRg-NIRS (NCT06400563)
- Testing
- MRg-NIRS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Keith D. Paulsen
Pancreatic Adenocarcinoma
Evaluation of Safety and Efficacy of Electrochemotherapy in the Treatment of Pancreatic Adenocarcinoma
The purpose of this study is to see how well electrochemotherapy works at treating people with Stage III pancreatic adenocarcinoma. Electrochemotherapy is a treatment that combines electroporation and chemotherapy administration.
- Trial name
- NCT02514421
- Testing
- Electroporation, gemcitabine, nab-paclitaxel
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Psychosis
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
Background Psychosis is a mental health condition that affects around 3 in 100 people in their lifetime. Most treatments for psychosis target a brain chemical called dopamine but they don't work for everyone and don't address…
- Trial name
- LEVHIPPRO (NCT06224530)
- Testing
- Levetiracetam
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- King's College London
Glioblastoma
Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma
The purpose of this study is to assess the efficacy, of treating patients with recurrent glioblastoma using Gamma-Knife Radiosurgery (GKS) to target a tumor volume defined by a combination of gadolinium enhancement and magnetic…
- Trial name
- GKS (NCT01011231)
- Testing
- Gamma Knife Radiosurgery
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Bone Tumor, Soft Tissue Tumor
Osteoarticular Tumor Characterization by Advanced Imaging
The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which…
- Trial name
- TUMOSTEO (NCT02895633)
- Testing
- Ecography, CT scan, MRI
- Where
- France
- Volunteers
- 1,090 people
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Disease, Healthy
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation).
- Trial name
- NCT00001874
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)