Clinical trials: Magnetoencephalography (MEG)
THC
Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.
- Trial name
- THC-MEG (NCT05641766)
- Testing
- THC
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Acute Effect of Three Neuroactive Drugs Measured by Magnetoencephalography (MEG), Electroencephalography (EEG) and the Synchronous Neural Interaction Test
This placebo-controlled crossover study is intended to measure the effect of three, common neuroactive medications on brain activity measured by magnetoencephalography (MEG) and electroencephalography (EEG).
- Trial name
- NCT00972985
- Testing
- modafinil, methylphenidate, lorazepam
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.
Healthy
Brain Activity During Production of Movement
This study will use electroencephalography (EEG) to examine how the brain prepares for movement. It will look at 1) what changes occur in a person's brain just before voluntary movement, 2) when the changes occur, 3) how…
- Trial name
- NCT00029939
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Schizophrenia Disorders, Psychosis
Magnetoencephalography in Psychosis Program
This research involves the examination of speech, thinking patterns and symptoms and recordings from brain's activity in patients with schizophrenia.
- Trial name
- MEGPSY (NCT06978881)
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Alzheimer Disease, Mild Cognitive Impairment
Memory Enhancement Using Transcranial Alternating Current Stimulation
The 32 million Alzheimer's disease (AD) and 69 million prodromal AD patients worldwide contribute to a large economic burden. Effective and safe therapies that slow or prevent the progression from mild cognitive impairment (MCI)…
- Trial name
- Memento (NCT06202872)
- Testing
- Gamma (40 Hz) tACS at the precuneus region
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Amsterdam UMC, location VUmc
Severe Enduring Anorexia Nervosa
Pilot Study of Deep Brain Stimulation for Severe Anorexia Nervosa
Anorexia Nervosa (AN) has the highest mortality of any psychiatric disorder and a paucity of effective treatments. AN becomes intractable in around 20%, resulting in huge individual and healthcare costs.
- Trial name
- NCT01924598
- Testing
- DBS to nucleus accumbens/anterior limb of internal capsule
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Oxford
Normal Physiology
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Researchers are testing a new type of magnetic field sensor called OPM.
- Trial name
- NCT04950309
- Testing
- SQUID MEG, OPM MEG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Pain
Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG
The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain.
- Trial name
- BODMEG (NCT03232723)
- Testing
- Whole-cortex MEG System (with optional EEG)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Suicide, Depressive Disorder, Treatment-Resistant
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective.
- Conditions
- Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action
- Trial name
- NCT06511908
- Testing
- (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Torticollis, Cervical Dystonia
Effects of Botulinum Toxin in Cervical Dystonia
Botulinum toxin injection in the contracting muscles has proven to be a safe and effective method of relieving pain and lessening dystonic posturing.
- Trial name
- NCT01056861
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Epilepsy
Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment…
- Trial name
- EPI-OPM (NCT07281222)
- Testing
- MEG OPM, MEG SQUID
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Motor Cortex, Primary Motor Cortex
Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
The whole body's voluntary movements are controlled by the brain. One of the brain areas most involved in controlling these voluntary movements is the motor cortex and it is often viewed as the primary 'output' region of the…
- Trial name
- MOBETA (NCT04727944)
- Testing
- Reach and grasp tasks in healthy participants using MEG technique (Experiment 1), Reach and grasp tasks in healthy participants using EEG technique (Experiment 2)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Schizophrenia
A Study of a Remediation Program of Social Cognition in Schizophrenia
Theory of mind (ability to infer others' intention, emotion, etc) is known to be altered in patients with schizophrenia and its deficit to be correlated with their decreased social proficiency.
- Trial name
- REMEDCOG (NCT01077791)
- Testing
- original cognitive therapy
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Magnetoencephalography, Optical Pump Magnetometer
Magnetoencephalography by Optical Pumping Magnetometer
MagnetoEncephaloGraphy (MEG) is a method of recording brain activity with high temporal resolution and good spatial resolution, compared to current recording techniques such as ElectroEncephaloGraphy (EEG).
- Conditions
- Magnetoencephalography, Optical Pump Magnetometer, Neonate, Premature
- Trial name
- MEG OPM (NCT05835817)
- Testing
- Magnetoencephalography
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fibromyalgia
Brain Rhythms in Fibromyalgia: A Magnetoencephalography (MEG) Study
The long-term purpose of the investigator's research is to understand the pathophysiological basis of chronic pain. This will help provide a framework for the development of effective treatments.
- Trial name
- FMP (NCT02159300)
- Testing
- experience brain activity recording
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Anxiety Disorders and Symptoms, Social Anxiety Disorder
Emotional Perceptual Training as a Treatment for Social Anxiety: Behavioral and Neural Evidence.
The Perceptual Training Study is a series of studies performed with the purpose of identifying a potential avenue for treatment of mood disorders, particularly anxiety-based mood disorders.
- Trial name
- PTL (NCT03437317)
- Testing
- Perceptual Retraining, Gender Discrimination
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Florida State University
Tinnitus, Subjective, Acoustic Stimulation
Cohort Study on Biomarkers and Clinical Treatment of Tinnitus
The goal of this clinical trial is to search for biomarkers in tinnitus patients in tinnitus patients and changes in biomarkers before and after treatment.
- Conditions
- Tinnitus, Subjective, Acoustic Stimulation, Transcranial Magnetic Stimulation, Repetitive, Magnetoencephalography
- Trial name
- NCT05871294
- Testing
- Acoustic stimulation, Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhiwu Huang, Ph.D.
Clinical High-risk Syndrome of Psychosis
RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
This study is an before-after study in the same subject, which enrolled 26 individuals with high-risk psychiatric syndrome (CHR). The target of subjects intervention relies on the results of magnetoencephalography localization.
- Trial name
- NCT06802952
- Testing
- rTMS
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Mental Health Center
Patients Diagnosed With a Malignant Glioma
Exploration and Characterization Ofintratumoral Electrophysiological Heterogeneity in Gliomas Using Magnetoencephalography
With more than 3,000 new cases per year in France, malignant gliomas are the most common malignant brain tumors in adults. Treatment consists of surgical removal when possible.
- Trial name
- GLIOMEG (NCT07616726)
- Testing
- MEG
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon