Clinical trials: Maintenance
Post Concussion Syndrome, Head Injury
Evaluation of Two Treatments for Chronic Post Concussion Syndrome
This study is designed to investigate factors that are associated with prolonged recovery from mild head injury. The investigators are particularly interested in defining the impact of anxiety related variables, such as health…
- Trial name
- NCT00871884
- Testing
- Psychoeducation, Relaxation Training, Interoceptive Exposure
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Postoperative Complications, Fatigue
Melatonin Treatment After Laparoscopic Cholecystectomy
Circadian disturbances occur after surgery. A double blinded, placebo controlled randomized clinical trial was made to investigate effects of melatonin on postoperative fatigue, sleep disturbances and general wellbeing.
- Conditions
- Postoperative Complications, Fatigue, Dyssomnias
- Trial name
- NCT00113906
- Testing
- melatonin
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insomnia, Depression
The Sleep Course: An Online Sleep Intervention for Adults With Self-reported Sleep Difficulties
This study evaluates an internet-delivered cognitive behavioural therapy for insomnia (ICBTi) intervention, known as the Sleep Course, within a routine online therapy clinic (the Online Therapy Unit).
- Conditions
- Insomnia, Depression, Anxiety
- Trial name
- NCT06745349
- Testing
- Sleep Course
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Regina
Primary Plasma Cell Leukemia
An Investigator-Initiated, Phase II, Multicenter, Open-Label, Single-Arm, Prospective Clinical Trial to Evaluate the Efficacy and Safety of Alternating Bortezomib-Based Regimens in Combination With DaratUMumab Followed by Maintenance With Daratumumab in the Frontline Setting of Primary Plasma CEll L
The primary objective of this study is to evaluate the efficacy of the alternating D-PAD/D-CVD induction regimen followed by D-CVD consolidation regimen and maintenance with daratumumab monotherapy, in terms of PFS, in the…
- Trial name
- EUMELEIA (NCT06636552)
- Testing
- Daratumumab (Subcutaneously)
- Where
- 7 sites in Greece
- Volunteers
- 43 people
- Sponsor
- Hellenic Society of Hematology
Multiple Myeloma
Use of Thalidomide, Lenalidomide, Carfilzomib, Bortezomib and Vorinostat in the Initial Treatment of Newly Diagnosed Multiple Myeloma Patients
The purpose of this study is to compare a standard chemotherapy regimen of cyclophosphamide, dexamethasone plus thalidomide with a newer regimen of cyclophosphamide, dexamethasone plus lenalidomide with or without carfilzomib.
- Trial name
- Myeloma XI (NCT01554852)
- Testing
- Induction (intensive pathway) - cyclophosphamide, lenalidomide, & dexamethasone (CRD) regimen, Induction (intensive pathway) - cyclophosphamide, thalidomide, & dexamethasone (CTD) regimen, Induction (intensive pathway) - carfilzomib, cyclophosphamide, lenalidomide, & dexamethasone (CCRD) regimen
- Where
- United Kingdom
- Volunteers
- 4,420 people
- Sponsor
- University of Leeds
Olfactory Disorder, Olfaction Disorders
Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the treatment of olfactory dysfunction.
- Conditions
- Olfactory Disorder, Olfaction Disorders, Olfactory Nerve Injuries, Olfactory Nerve Disorder
- Trial name
- NCT04406584
- Testing
- Injection into olfactory cleft
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Transplants and Implants
Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant
The purpose of the study was to determine if rapid discontinuation of corticosteroids (also known as prednisone withdrawal) and maintenance immunosuppression with Prograf (tacrolimus) and CellCept (mycophenolate mofetil) while…
- Trial name
- NCT00596947
- Testing
- prednisone, rabbit antithymocyte globulin, Tacrolimus
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Pennsylvania
Sleep Bruxism, Adult, Splints
Occlusal Splints in the Treatment of Sleep Bruxism
Occlusal splints are employed in the treatment of sleep bruxism. These appliances decrease sleep-related actions and damages bruxism, like grinding, tooth-wear, headache, and temporomandibular joint disorders.
- Conditions
- Sleep Bruxism, Adult, Splints, Sleep
- Trial name
- bruxism (NCT04934449)
- Testing
- Occlusal splint
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Insomnia
Efficacy and Safety of Two Doses of Hipnos in the Treatment of Adults With Insomnia
The purpose of this study is to evaluate the efficacy and safety of three doses of Hipnos medication in adults with insomnia.
- Trial name
- NCT03814135
- Testing
- Hipnos 3, Hipnos 5
- Sponsor
- EMS
Primary Insomnia
Study of the Insomnia in Patients With Low Back Pain
The purpose of this study is to examine whether insomnia due to chronic low back pain can improve with use of eszopiclone.
- Trial name
- NCT00365976
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Opioid-Related Disorders, Substance-Related Disorders
Buprenorphine Maintenance Dose Schedule and Treatment Setting - 1
The purpose of this study is to assess optimal dosage of buprenorphine on a thrice weekly schedule in a pilot clinical trial.
- Trial name
- NCT00000318
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Asthma
A Study to Compare the Efficacy of Fluticasone Furoate/Vilanterol Inhalation Powder With Usual Inhaled Corticosteroids (ICS)/Long Acting Beta Agonists (LABA) in Persistent Asthma
The combination of FF, an ICS and VI, an orally inhaled LABA has been developed as a once-daily combination therapy for the long-term maintenance treatment of asthma in adults and children >=12 years of age.
- Trial name
- NCT02446418
- Testing
- Fluticasone Furoate, Vilanterol, Fluticasone propionate
- Where
- 93 sites in France, Germany
- Volunteers
- 423 people
- Sponsor
- GlaxoSmithKline
Multiple Myeloma, Multiple Myeloma Without Mention of Remission
Evaluating the Uptake and Utility of Clinical Pathways for Newly Diagnosed Patients With Multiple Myeloma
All4Cure is partnering with community oncology practices participating in the Quality Cancer Care Alliance (QCCA) and Exigent Research to develop a clinical pathway that standardizes the evaluation, treatment and ongoing…
- Trial name
- NCT06149910
- Testing
- Multiple Myeloma Pathway, All4Cure Platform, Documentation Pathway
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- All4Cure
Multiple Sclerosis
Cognitive Functions in Patients With Multiple Sclerosis
Approximately 65% of multiple sclerosis (MS) patients appear to have problems in their cognitive function. Long-term memory is one of the most frequently affected functions in MS patients.
- Trial name
- NCT03594357
- Where
- Turkey (Türkiye)
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Gazi University
Temporomandibular Joint Disorders, Restless Legs Syndrome
Restless Legs Syndrome in Temporomandibular Joint Disorders
This observational, cross-sectional, descriptive study aims to evaluate the prevalence of restless legs syndrome in patients with temporomandibular joint dysfunction and to investigate its effects on sleep quality and…
- Conditions
- Temporomandibular Joint Disorders, Restless Legs Syndrome, Sleep Quality
- Trial name
- NCT07292077
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Opioid-use Disorder, Adherence, Medication
Social Networks and Methadone Maintenance Treatment Retention and Antiretroviral Therapy Retention in Tanzania
Investigators will adapt the Brief Social Behaviour and Network Therapy (B-SBNT) intervention developed to facilitate recovery among people receiving medication-assisted treatment for opioid use disorder in the United Kingdom.
- Conditions
- Opioid-use Disorder, Adherence, Medication, HIV Infections
- Trial name
- NCT04479475
- Testing
- Supportive care through community support persons
- Where
- Tanzania
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Metastatic Breast Cancer
Maintenance Bevacizumab or Observation After Taxane Based First Line Chemotherapy In Metastatic Breast Cancer
Investigators propose to assess,the safety and tolerability profile (number of participants with adverse events)of bevacizumab (Avastin) when combined with standard chemotherapy as first line treatment of patients with metastatic…
- Trial name
- NCT01978977
- Where
- 6 sites in Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Oncology Research Group
Obesity
Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for…
- Trial name
- NCT02043457
- Testing
- phenotyping
- Where
- United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Vulvar Cancers
A PHASE II, RANDOMIZED TRIAL TO ASSESS MAINTENANCE THERAPY WITH CEMIPLIMAB VERSUS BEST SUPPORTIVE CARE AFTER 1ST LINE PLATINUM-BASED CHEMOTHERAPY IN ADVANCED/RECURRENT VULVAR CANCER
This is a phase II, randomized study that will include 42 participants who have received 4 to 6 cycles of first-line platinum-based chemotherapy for advanced vulvar squamous cell carcinoma (SCC) not amenable to curative surgical…
- Trial name
- BRAVA VULVAR (NCT07101848)
- Testing
- Cemiplimab
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Hospital Israelita Albert Einstein