Clinical trials: Maintenance Phase
Breast Neoplasms
Maintenance Treatment With Liposomal Doxorubicin (Caelyx) in Metastatic Breast Cancer Patients
This is a randomized, prospective and multicenter phase IV clinical trial, which has been designed as a phase III study. One hundred fifty-four women (77 per treatment arm) will be recruited in the study.
- Trial name
- NCT00128778
- Testing
- Pegylated liposomal doxorubicin
- Where
- Spain
- Volunteers
- 288 people
- Sponsor
- Spanish Breast Cancer Research Group
Acute Myeloid Leukemia
Enasidenib (AG-221) Maintenance Post Allogeneic HCT in Patients With IDH2 Mutation
This phase II trial studies the side effects of using enasidenib as maintenance therapy in treating patients with acute myeloid leukemia with IDH2 mutation following donor stem cell transplant.
- Trial name
- NCT03728335
- Testing
- Enasidenib Mesylate
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- City of Hope Medical Center
Kidney Transplant
Study to Evaluate the Efficacy and Safety of Tacrolimus in Kidney Transplant Recipients (BLOSSOM)
The purpose of this study is to evaluate the efficacy and Safety after conversion to TacroBell SR cap. or TacroBell cap. in patients who in renal transplant patients undergoing maintenance therapy with Reference Tacrolimus.
- Trial name
- NCT04224350
- Testing
- TacroBell SR cap., Tacrolimus cap.
- Where
- South Korea
- Volunteers
- 184 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Carcinoma, Nonsquamous Non-small-cell Lung
Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, versus (vs) pembrolizumab plus maintenance pemetrexed for the treatment of non-squamous NSCLC. The study's 2 primary hypotheses are: 1.
- Trial name
- NCT03976323
- Testing
- Pembrolizumab, Pemetrexed, Carboplatin
- Where
- 178 sites in United States, Argentina and 18 more
- Volunteers
- 1,003 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Insomnia
Brief Behavioral Treatment of Insomnia in Military Veterans: Phase 2 (BBTIMVII)
The purpose of this study is to adapt and test the effects of a 4-week behavioral treatment that targets chronic insomnia (lasting >1 month) in service members returning from Operation Iraqi Freedom (OIF) and Operation Enduring…
- Trial name
- BBTIMVII (NCT00840255)
- Testing
- BBTI-MV, Information Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Cervical Cancer
A Phase II Clinical Trial of Cediranib and Olaparib Maintenance in Advanced Recurrent Cervical Cancer
COMICE is a randomised, double blind placebo controlled Phase II trial. The trial is recruiting 108 patients with advanced recurrent cervical cancer who have completed their 1st line chemotherapy for advanced/recurrent disease.
- Trial name
- COMICE (NCT04487587)
- Testing
- Cediranib, Olaparib
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Endometrial Cancer, Papillary Serous Endometrial Carcinoma
Trial of Maintenance With Niraparib- Uterine Serous Carcinoma
Uterine serous carcinoma (USC) accounts for up to 40% of endometrial cancer-related deaths. Patients with USC share many genomic and clinical characteristics with patients who has serous ovarian cancer.
- Conditions
- Endometrial Cancer, Papillary Serous Endometrial Carcinoma, Uterine Serous Carcinoma, Endometrial Carcinoma
- Trial name
- NCT04080284
- Testing
- Niraparib
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Northwell Health
Non-muscle Invasive Bladder Cancer
A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer
The purpose of this study is to learn about the safety and effects of the study medicine (sasanlimab) in people with non-muscle invasive bladder cancer.
- Trial name
- CREST (NCT04165317)
- Testing
- PF-06801591, Bacillus Calmette-Guerin
- Where
- 196 sites in United States, Australia and 12 more
- Volunteers
- 1,068 people
- Sponsor
- Pfizer
Anesthesia, Sevoflurane
MAAS Method (Minimal-flow Auto-control Anesthesia System) for the Administration of Desflurane and Sevoflurane
In the present work the investigators will study the accuracy of the MAAS (Minimal-flow Autocontrol Anesthesia System) method to estimate the percentage of halogenated anesthetic (HA) to be supplied to the anesthetic circuit…
- Conditions
- Anesthesia, Sevoflurane, Desflurane, Low Flow Anesthesia
- Trial name
- MAAS (NCT05511610)
- Testing
- Sevoflurane uptake and supply, Washout phase, Desflurane uptake and supply
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Hepatitis C
A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and Methadone
The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) TMC435 (150 mg, once a day) on the steady state pharmacokinetics (what the body does to the medication) of R…
- Trial name
- NCT00915564
- Testing
- TMC435, Methadone
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Chronic Myeloid Leukemia
TKI and Interferon Alpha Evaluation Initiated by the German Chronic Myeloid Leukemia Study Group - the TIGER Study
Advances in Chronic Myeloid Leukemia (CML) therapy led to an expected survival prolongation of > 20 years after diagnosis. So far, discontinuation of tyrosine kinase inhibitors led to recurrence of disease in the majority of…
- Trial name
- TIGER (NCT01657604)
- Testing
- Peginterferon α2b, Nilotinib
- Where
- 112 sites in Czechia, Germany and 1 more
- Volunteers
- 717 people
- Sponsor
- University of Jena
Stage IV Pancreatic Cancer
Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer
The Investigators in the PCRT team have developed a therapeutic regimen which attacks both the tumor compartment and the stromal compartment of pancreatic cancer and induces complete responses in a small percentage of patients…
- Trial name
- NCT01488552
- Testing
- Gemcitabine, nab-paclitaxel, FOLFIRINOX
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pancreatic Cancer Research Team
Multiple Myeloma
GEM05 for Patients With Multiple Myeloma Under 65 Years
The primary objective is to compare safety and efficacy of three induction treatments: VBMCP-VBAD / Velcade versus Thalidomide / Dexamethasone versus Velcade / Thalidomide / Dexamethasone.
- Trial name
- GEM05MENOS65 (NCT00461747)
- Testing
- VBMCP/VBAD/Velcade, Thalidomide/Dexamethasone, Velcade/Thalidomide/Dexamethasone
- Where
- 79 sites in Spain
- Volunteers
- 390 people
- Sponsor
- PETHEMA Foundation
Ovarian Cancer, Ovarian Neoplasms
A Trial of Vigil for Participants With Ovarian Cancer
The goal of this clinical trial is to compare participants with ovarian, fallopian tube or primary peritoneal cancer when treated with investigational product (Vigil) compared to placebo.
- Trial name
- VITAL (NCT02346747)
- Testing
- Vigil
- Where
- 26 sites in United States
- Volunteers
- 92 people
- Sponsor
- Gradalis, Inc.
Anaplastic Thyroid Cancer, Thyroid Cancer
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
This multicenter study examines the safety and feasibility of the combination of neoadjuvant XL092 and cemiplimab prior to surgical resection in participants with wild-type (WT) anaplastic thyroid cancer (ATC) that has a BRAF…
- Conditions
- Anaplastic Thyroid Cancer, Thyroid Cancer, BRAF Mutation-Related Tumors
- Trial name
- NEO-COMBATXL (NCT06902376)
- Testing
- Cemiplimab, XL092
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HIV-1 Infection
Capacity of the Dual Combination Raltegravir/Etravirine to Maintain Virological Success in HIV-1 Infected Patients of at Least 45 Years of Age- ANRS 163 ETRAL
This multicenter, international, non randomized (single arm), open, phase II trial aims to evaluate the capacity of the dual combination raltegravir/etravirine to maintain virological success in virologically suppressed HIV-1…
- Trial name
- NCT02212379
- Testing
- raltegravir and etravirine
- Where
- 19 sites in France, Spain
- Volunteers
- 170 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hemodialyzed Patients, Epoetin Treatment
Epoetin Dosing Regimens in Haemodialysis
Currently, less frequent than once weekly subcutaneous epoetin administration regimens were shown to be equally effective and safe as the once-weekly schedules in stable pre-dialyzed and peritoneal dialyzed patients…
- Trial name
- NCT00349960
- Testing
- NeoRecormon SC once-weekly versus once-every-other-week
- Where
- 9 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Romanian Society of Nephrology
Metastatic Pancreatic Adenocarcinoma, Pancreatic Cancer
Metastatic Non-Familial Adenocarcinoma Maintenance Therapy With DZ-002: Heptamine Carboxymethine Dye Conjugate
The goal of this clinical trial is to learn if drug DZ-002 works to treat adults with metastatic pancreatic adenocarcinoma. It will also learn about the safety of drug DZ-002.
- Trial name
- DZ-002-201 (NCT07344220)
- Testing
- DZ-002 - 5 mg/kg, 6 mg/kg, or 7 mg/kg
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Anemia
An Observational Study of Mircera (Methoxy Polyethylene Glycol-Epoetin Beta) in Stage III-IV Chronic Kidney Disease Patients Not on Dialysis With Renal Anemia
This observational study will evaluate the use in clinical practice and efficacy of Mircera (methoxy polyethylene glycol-epoetin beta) in stage III-IV chronic kidney disease patients not on dialysis receiving Mircera for the…
- Trial name
- NCT01695746
- Testing
- C.E.R.A.
- Where
- 6 sites in India
- Volunteers
- 108 people
- Sponsor
- Hoffmann-La Roche
Triple -Negative Breast Cancer
Capecitabine as Maintenance Therapy vs Observation in Early-stage Triple-negative Breast Cancer
Eligible patients was assigned in a 1:1 ratio to receive either low-dose capecitabine maintenance (intervention group) which is newly diagnostic to be planned to receive capecitabine after finishing the standard adjuvant…
- Trial name
- NCT07143097
- Testing
- capecitabine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University