Clinical trials: Major Abdominal Surgeries
Peritoneal Carcinomatosis
A Nomogram to Predict Major Postoperative Complications After Cytoreductive Surgery and HIPEC Based on Pre and Peroperative Criteria: Which Patient Require Intensive Monitoring?
In this study, the investigators tend to highlight pre and peroperative factors that predict major postoperative complication after a surgery for resection of peritoneal carcinomatosis.
- Trial name
- NCT05547568
- Testing
- Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
- Where
- France
- Volunteers
- 219 people
- Sponsor
- CHU de Reims
Major Abdominal Surgery
Immunonutrition Versus Standard Enteral Nutrition Before Major Surgery
The aim of this trial is to compare preoperative Imunnonutrition with standard enteral nutrition regarding morbidity after major abdominal surgery in patients with NRS greater 3.
- Trial name
- NCT00512213
- Testing
- Immunonutrition for 5 days preoperative, Standard enteral nutrition for 5 days preoperative
- Where
- Switzerland
- Volunteers
- 154 people
- Sponsor
- University of Lausanne Hospitals
Postoperative Pain
Tegileridine vs Sufentanil for Postoperative Pain Management and Gastrointestinal Recovery After Major Laparoscopic Abdominal Surgery
This study is a single-center, randomized, triple-blind clinical trial designed to compare tegileridine and sufentanil for postoperative analgesia and gastrointestinal tolerability in patients undergoing major laparoscopic…
- Trial name
- TASPER (NCT07637968)
- Testing
- Tegileridine, Sufentanil, Palonosetron
- Volunteers
- 84 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Soft Tissue Bleeding
The Severe Soft Tissue Bleeding Study
The objective of this study is to evaluate the safety and hemostatic effectiveness of the Fibrin Pad (FP) versus standard of care treatment (SoC) in controlling challenging severe soft tissue bleeding during abdominal, pelvic…
- Trial name
- NCT00977925
- Testing
- Fibrin Pad, Standard of Care
- Where
- 17 sites in Australia, Germany and 2 more
- Volunteers
- 91 people
- Sponsor
- Ethicon, Inc.
Incisional Hernia Occurence
Assessment of Risk Factors for Incisional Hernia Following Major Abdominal Surgery
The aim of this study is to assess the independent patient-related and surgery-related risk factors associated with the development of incisional hernia following major abdominal surgeries.
- Trial name
- NCT07790172
- Testing
- cases, controls
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Pain Management
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Opioid Consumption in Patients Undergoing Major Abdominal Surgery
This study aims to design a prospective, double-blind, randomized controlled trial to compare the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative visceral pain in patients undergoing major…
- Trial name
- NCT07260266
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 108 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Abdominal Aortic Aneurysm Uncomplicated
Goal Directed Therapy for Patients Undergoing Major Vascular Surgery
The management and delivery of intravenous fluids during surgical operations is one of the important duties for anesthesiologists.
- Trial name
- NCT01681251
- Testing
- Fluid titrated with the use of arterial pulse contour cardiac output monitor if SVV >13%, Fluid titrated at the discretion of the attending anesthesiologist
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Postoperative Care
Postoperative Oral Intake Trial
Complete fasting until resumed bowel function after upper abdominal surgery is not beneficial. Enteral feeding has been claimed to be the preferred way of delivering nutritional support postoperatively.
- Trial name
- NCT00134407
- Testing
- Normal diet, Nutrition via jejunal needle-catheter
- Where
- Norway
- Volunteers
- 450 people
- Sponsor
- University Hospital of North Norway
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Abdominal Pain
Continuous Local Anesthetic and Steroid Infusion in Abdominal Surgery
The aim of the study is the identification, comparing continuous infusion of local anesthetics and steroids intralesionally with the current gold standard therapy (PCA), of the effective dose of local anesthetics and steroids…
- Trial name
- GR-CWI (NCT02002663)
- Testing
- ropivacaine 0.2%, Methylprednisolone 1mg/kg, saline 0.9%
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Third Degree Burn, Second Degree Burn
Diagnostic of Infections Following Major Abdominal Surgery and Burn Injury
This study was designed to investigate, if new biomarkers may improve the early diagnostic of infections following major abdominal surgery and severe burn injuries.
- Trial name
- Earlygnost (NCT01055587)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Klinikum St. Georg gGmbH
Major Abdominal Surgery
Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery
Host systemic responses to vigorous stimuli as trauma, surgical tissue injury, anesthesia and post-operative pain, leads to release a variety of pro-inflammatory cytokines including interleukin-1 (IL-1) and interleukin-6 (IL-6)…
- Trial name
- NCT03793075
- Testing
- Ketamine, Propofol
- Volunteers
- 36 people
- Sponsor
- Mansoura University Hospital
Hemodynamic Instability
Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach
This study compares the actual standard of care with a new protocol to guide hemodynamic optimization during major abdominal surgery, which is more tailored on patient real needs.
- Trial name
- HEART-CORE (NCT03113435)
- Testing
- Oxygen consumption optimization
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Technology
Evaluation of the IKORUS Technology in Patients Undergoing Major Abdominal Surgery
The goal of this observational substudy is to evaluate the feasibility, performance and behavior of the IKORUS (Advanced Perfusion Diagnostics, Villeurbanne, France), a new tissue perfusion device using urethral…
- Trial name
- NCT04187274
- Testing
- IKORUS technology
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Erasme University Hospital
Oxycodone, Chronic Pain, Postoperative
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain
The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery.
- Trial name
- AOPC (NCT06721988)
- Testing
- oxycodone and parecoxib sodium combinations
- Volunteers
- 1,316 people
- Sponsor
- Ailin Luo
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Intraoperative Hypotension
Hypotension Prediction Index and Intraoperative Hypotension Incidence
This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery.
- Trial name
- NCT06909786
- Testing
- HPI guided hemodynamic management, standard arterial line
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pain
A Phase Ⅱ Study to Evaluate the Efficacy and Safety of YZJ-4729 in Patients With Moderate to Severe Acute Pain After Abdominal Surgery
Primary Objective： To explore the analgesic efficacy of YZJ-4729 compared with placebo in patients with acute postoperative pain following abdominal surgery.
- Trial name
- NCT06680466
- Testing
- YZJ-4729, morphine
- Where
- China
- Volunteers
- 179 people
- Sponsor
- Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
Malignant Gastrointestinal Neoplasm, Malignant Peritoneal Neoplasm
Consumer-Based Activity Monitor in Evaluating and Measuring Activity of Older Patients With Abdominal Cancer Undergoing Surgery
This pilot clinical trial studies how well consumer-based activity monitor works in evaluating and measuring activity of older patients with abdominal cancer undergoing surgery.
- Trial name
- NCT02356471
- Testing
- Management of Therapy Complications Fitbit Zip (portable pedometer device), Questionnaire Administration, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Wake Forest University Health Sciences
Major Abdominal Surgery
Paravertebral Block vs. General Anesthesia for Major Abdominal Surgery
Elderly patients are usually presented with higher risk for developing cardiopulmonary complications after general anesthesia (GA).
- Trial name
- NCT02534012
- Testing
- Paravertebral block, General anesthesia, Major abdominal surgery
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Makassed General Hospital