Clinical trials: Major Abdominal Surgeries
Colon Cancer, Inflammatory Bowel Diseases
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early post operative physical…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT00982618
- Testing
- Lidocaine, Epidural Block, PCA Morphine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Postoperative Pulmonary Complications
AI-Assisted Education Before Surgery to Prevent Lung Complications in Older Surgical Patients
This study aims to determine whether preoperative patient education prepared with the assistance of artificial intelligence can reduce lung complications after major abdominal surgery in older patients.
- Trial name
- NCT07889557
- Testing
- Artificial Intelligence-Assisted Preoperative Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 242 people
- Sponsor
- Hilal KAHRAMAN
Paralytic Ileus
Effect of Preoperative Intrathecal Dexamethasone Versus Dexmedetomidine on Paralytic Ileus After Major Abdominal Surgery
Postoperative Ileus (POI) is considered as intolerance of oral intake due to disruption of the normal coordinated propulsive motor activity of the gastrointestinal (GI) tract following abdominal or non-abdominal surgery.
- Trial name
- NCT06752317
- Testing
- Dexamethasone, Dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Blood Pressure, Dexmedetomidine
Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes
Perioperative organ injuriy remain an important threat to patients undergoing major surgeries. Intraoperative hypotension is associated with an increase in postoperative morbidity and mortality.
- Conditions
- Blood Pressure, Dexmedetomidine, High-risk Patients, Abdominal Surgery
- Trial name
- NCT03933306
- Testing
- Dexmedetomidine, Goal-directed blood pressure management, Routine blood pressure management
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Peking University First Hospital
Elective Major Abdominal Surgery
Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.
This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery.
- Trial name
- NCT07303855
- Testing
- Goal-Directed Fluid Therapy (GDFT)
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Surgical Site Infection
Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective Surgeries
Pragmatic randomized clinical trial comparing Iodine Povacrylex based on alcohol to Chlorhexidine also based on alcohol in efficacy and security to diminish frequency of surgical site infections in major abdominal elective clean…
- Trial name
- NCT03859908
- Testing
- Iodine Povacrylex 7 MG/ML / Isopropyl Alcohol 0.74 ML/ML, Chlorhexidine Gluconate 20 MG/ML / Isopropyl Alcohol 0.7 ML/ML
- Where
- El Salvador
- Volunteers
- 18 people
- Sponsor
- Universidad de El Salvador
Acute Kidney Injury
Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
- Trial name
- NCT04130347
- Volunteers
- 499 people
- Sponsor
- Uppsala University
Neoplasms Malignant, Surgery
Improved Adherence With Extended Venous Thromboembolism Prophylaxis After Major Cancer Surgery
This is a prospective, twin-center, cohort study in patients discharged from the hospital after major abdominal or pelvic cancer surgery for cancer.
- Conditions
- Neoplasms Malignant, Surgery, Venous Thromboembolism, Prophylaxis
- Trial name
- NCT04479579
- Testing
- Apixaban 2.5 milligram
- Where
- 2 sites in Canada
- Volunteers
- 53 people
- Sponsor
- McMaster University
Hypothermia
Impact of Prewarming on Perioperative Body Core Temperature and the Outcomes of Cytoreductive- and Major Open Abdominal Surgery: A Randomised Trial
The primary purpose of this study is to determine whether a prewarming period of at least 30 minutes during induction of general and combined epidural anesthesia reduces the core temperature drop normally occuring in patients…
- Trial name
- PREWARM (NCT02364219)
- Testing
- Prewarming, Microdialysis
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Charite University, Berlin, Germany
Aortic Aneurysm
Melatonin and Cardiac Outcome After Major Surgery
The purpose of this study is to assess whether treatment with melatonin can reduce cell damage and inflammatory stress response and thereby occurrence of myocardial injury after abdominal aortic surgery.
- Trial name
- NCT00315926
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Major Abdominal Surgeries
Cold Water Gargling After Major Abdominal Surgery
This randomized controlled trial examined the effect of cold water gargling on postoperative oral dryness, thirst severity, and patient satisfaction in patients who underwent major abdominal surgery.
- Trial name
- NCT07506226
- Testing
- Cold water gargling
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- TC Erciyes University
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Postoperative Complications
Etomidate to Improve Outcome in Elderly Patients
Elderly patients have high mortality and postoperative complications rate after surgery, especially postoperative cardiac complications.
- Trial name
- EPIC (NCT02910206)
- Testing
- Etomidate, propofol, Sufentanil
- Where
- China
- Volunteers
- 1,917 people
- Sponsor
- Zhihong LU
Non-Cardiac/ Non-Thoracic Surgery, Abdominal Surgery
Assisted Fluid Management IDE Study
The primary objective of this study is to evaluate the performance of the Acumen™ Assisted Fluid Management (AFM) Feature in its ability to predict a subject's fluid responsiveness.
- Conditions
- Non-Cardiac/ Non-Thoracic Surgery, Abdominal Surgery, Pelvic Surgery, Major Peripheral Vascular Surgery
- Trial name
- AFM (NCT03469570)
- Testing
- EV1000 Clinical Platform with Assisted Fluid Management (AFM) Feature
- Where
- 10 sites in United States
- Volunteers
- 330 people
- Sponsor
- Edwards Lifesciences
Postoperative Pain, Inflammatory Response
Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery
This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
- Trial name
- NCT03958942
- Testing
- Ultrasound quadratus lumborum block with bupivacaine 25%, lumbar epideural block with bupivacaine 25%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Perioperative Myocardial Injury
Perioperative Reduction of Inapparent Myocardial Injury
Recent data suggests that subclinical myocardial injury occurs in patients undergoing major abdominal surgery, and the degree of damage is proportionally linked to morbidity and mortality in the short and medium terms.
- Trial name
- PRIME (NCT01850927)
- Testing
- Remote ischaemic preconditioning, Control
- Where
- United Kingdom
- Volunteers
- 84 people
- Sponsor
- London Surgical Research Group
Abdominal Cancer, Blood Pressure
The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery
Esophageal Doppler Monitoring (Deltex CardioQ Esophageal Doppler Monitor, ODM) is used to manage patients' fluid therapy by non-invasively measuring continuous cardiac output with an esophageal probe.
- Conditions
- Abdominal Cancer, Blood Pressure, Cardiac Indices
- Trial name
- NCT06293391
- Testing
- cardiac indices in supine and trendelenburg position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital