Clinical trials: Major Abdominal Surgery
Inguinal Hernia, Chronic Pain
A National Center for Persistent Severe Pain After Groin Hernia Repair
This prospective, consecutive cohort study presents nationwide 5-year outcome data on patients with severe persistent pain after groin hernia repair (SPG).
- Trial name
- Q5Y (NCT03713047)
- Volunteers
- 222 people
- Sponsor
- University of Copenhagen
Postoperative Complication
Effect of Remote Ischemic Preconditioning on Postoperative Complications in Visceral Surgery
Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion.
- Trial name
- RIPC (NCT02375269)
- Testing
- RIPC with a tourniquet
- Where
- Switzerland
- Volunteers
- 526 people
- Sponsor
- University of Zurich
Major Abdominal Surgery
Paravertebral Block vs. General Anesthesia for Major Abdominal Surgery
Elderly patients are usually presented with higher risk for developing cardiopulmonary complications after general anesthesia (GA).
- Trial name
- NCT02534012
- Testing
- Paravertebral block, General anesthesia, Major abdominal surgery
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Makassed General Hospital
Surgery, Malnutrition
Malnutrition is a Severe Health Issue for Cancer Patients. This Study Examines How Preoperative Nutritional Status Affects Postoperative Delirium in Patients Undergoing Major Abdominal Surgery for Gynecological and Gastrointestinal Tumors.
The World Health Organization (WHO) identifies malnutrition as a significant public health threat. It is a common issue among cancer patients due to various factors.
- Conditions
- Surgery, Malnutrition, Delirium, Postoperative, Abdominal Neoplasm
- Trial name
- NCT06657599
- Testing
- Major Abdominal Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Electrical Cardiometry VS Esophageal Doppler
Hemodynamic Monitoring and Correlation Between Electrical Cardiometry and Esophageal Doppler in Patients Undergoing Major Abdominal Surgery
The aim of this study is to correlate hemodynamic monitoring between noninvasive Electrical Cardiometry and minimally invasive Esophageal Doppler in patients undergoing major abdominal surgery
- Trial name
- NCT04255550
- Testing
- Esophageal doppler
- Where
- Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pilot Study
A Trimodal Prehabilitation Study for Patients Undergoing Major Abdominal Surgery
Prehabilitation programmes have the potential to reduce post-operative complications following abdominal cancer surgery by improving pre-operative fitness levels.
- Trial name
- NCT04047524
- Testing
- Monitoring using a FitBit
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Shira Baram
Pediatric Cancer, Pain, Postoperative
Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries
Surgical trauma initiates multiple physiological mechanisms that cause postoperative pain. Postoperative pain has nociceptive, inflammatory, and neuropathic components.Inadequate relief of postoperative pain leads to significant…
- Trial name
- NCT03580980
- Testing
- Paracetamol and ketamine, Caudal levobupivacaine, Morphine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Heart Failure
Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries
The objective of this pilot study is to evaluate the efficacy and safety of preoperative administration of levosimendan in patients with chronic heart failure scheduled for major abdominal cancer surgery assuming the reduction of…
- Trial name
- NCT03557255
- Testing
- Levosimendan, Saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Norepinephrine, Post-induction Hypotension
Determination of the ED50 and ED95 of Prophylactic Norepinephrine Infusion for Preventing Post-induction Hypotension in Elderly Patients Undergoing Major Abdominal Surgery
The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down…
- Trial name
- NCT05637164
- Testing
- norepinephrine bitartrate
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Major Abdominal Surgery
Albumin Kinetics in Generalized Inflammation
The purpose of this study is to determine whether the kinetics of endogenous albumin is altered by the generalized inflammation caused by major abdominal surgery.
- Trial name
- NCT01194492
- Testing
- Albumin transcapillary escape rate (125I-albumin)
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Ileus
Thoracic Epidural for Postoperative Ileus
The investigators try to find whether thoracic epidural analgesia (TEA) shortens the first gas-out time compared to iv-PCA and promotes earlier discharge after major upper abdominal surgery.
- Trial name
- NCT02491385
- Testing
- thoracic epidural analgesia, iv-PCA
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samsung Medical Center
Surgical Procedure, Unspecified, Postoperative Complications
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors
The goal of this clinical trial is to identify those situations in which the increase of lactate levels is not clinically relevant since it is associated with altered genetic polymorphism of the genes involved in the membrane…
- Conditions
- Surgical Procedure, Unspecified, Postoperative Complications, Hyperlactatemia, Abdomen Disease
- Trial name
- NETTUNO (NCT06222021)
- Testing
- Genetic analysis of polymorphism of membrane receptors involved in lactate transport
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bowel Disease, Liver Diseases
The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery
Major abdominal surgery - like non-laparoscopic bowel resection, liver, gastric, or pancreas surgery - is performed under general anesthesia.
- Conditions
- Bowel Disease, Liver Diseases, Pancreas Disease, Anesthesia; Functional
- Trial name
- NCT04021264
- Testing
- Ropivacaine-Sufentanil, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
CGM, Intensive Care (ICU)
Evaluate the Performance of the Dexcom G7 Continuous Glucose Monitoring (CGM) System in Critically Ill Patients Undergoing Major Abdominal Surgery and Solid Organ Transplantation Which Require Blood Glucose Monitoring for Intensive Insulin Therapy.
Main objective: The goal is to to determine the accuracy of Dexcom G7 Continuous glucose monitor system in critically ill patients, undergoing major abdominal surgery and solid organ transplantation, in the intensive care unit.
- Conditions
- CGM, Intensive Care (ICU), Liver Transplant Surgery, Solid Organ Transplantation
- Trial name
- DREAM-ICU (NCT07611721)
- Testing
- Continuous glucose monitor
- Where
- Czechia
- Volunteers
- 62 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Postoperative Pain
Postoperative Pain Relief After Major Abdominal Gynecological Surgery
The aim of our study was to compare the effects of Lomber Epidural Analgesia (LEA), Transversus Abdominis Plane (TAP) block and Local Anesthetic Infiltration (LAI) on postoperative morphine consumption, time to first recue…
- Trial name
- NCT05845385
- Testing
- lumbar epidural analgesia with bupivacaine, transversus abdominis plane block with bupivacaine, wound infiltration with bupivacaine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Major Abdominal Surgery, Chronic Pain
Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants
The opioid crisis is a growing problem around the world, with prescription opioids being a major contributor to this crisis. They can be prescribed in different chronic and acute settings, such as surgery.
- Conditions
- Major Abdominal Surgery, Chronic Pain, Opioid Use
- Trial name
- POCAS (NCT05197465)
- Testing
- Questionnaires
- Where
- 2 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiac Output Measurement
Comparative Noninvasive Continuous Cardiac Output by the Clearsight® With Invasive Monitoring by PICCO® in Abdominal Major Surgery
In high-risk patients, it is now recommended to guide the intraoperative volume replacement via the stroke volume. Today, the most commonly used technique for estimating the stroke volume is the transpulmonary thermodilution and…
- Trial name
- CLEARPICCO (NCT02941952)
- Testing
- Cardiac output and stroke ejection volume monitoring with both ClearSight® and PICCO® in major abdominal surgery.
- Where
- France
- Sponsor
- Poitiers University Hospital
Aortic Aneurysm, Abdominal, Arterial Occlusive Diseases
Plasma Transfusion in Major Vascular Surgery
BACKGROUND Major blood loss is frequent in open repair of ruptured and intact abdominal aortic aneurysm (AAA) as well as in aorto-bifurcated prosthesis insertion due to aortoiliac occlusive disease.
- Trial name
- NCT04514575
- Testing
- Plasma transfusion
- Where
- Denmark
- Volunteers
- 17,000 people
- Sponsor
- Naestved Hospital
Major Surgery, Intraabdominal Hypertension
Different Intra-abdominal Pressures and Optic Nerve Size
In intensive care patients, high intraabdominal pressure is frequently encountered. Intra-abdominal pressure is often measured as high, especially after major abdominal surgery procedures.
- Conditions
- Major Surgery, Intraabdominal Hypertension, Optic Nerve Congestion
- Trial name
- NCT04556877
- Testing
- Intraabdominal pressure and optic nerve diameters
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Trakya University
Pain
Efficacy and Safety Study of Meloxicam Nanocrystal Injection for the Treatment of Moderate to Severe Pain
The purpose of this study is to evaluate the efficacy and safety of meloxicam nanocrystal injection in subjects with moderate to severe pain after abdominal surgery.
- Trial name
- NCT06379165
- Testing
- Meloxicam Nanocrystal Injection
- Where
- China
- Volunteers
- 192 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.