Clinical trials: Major Bleed
Blood Transfusion
Effect of Indication Based Blood Product Transfusion in Patients Undergoing Major Oncological Surgery
Investigators aimed to compare the effect on different indications (blood volume loss based VS hemoglobin concentration based ) based blood transfusion practices in patients undergoing major oncological surgery for pelvic or…
- Trial name
- NCT05607940
- Testing
- blood volume loss based blood transfusion, hemoglobin concentration based blood transfusion
- Volunteers
- 260 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Soft Tissue Bleeding
The Severe Soft Tissue Bleeding Study
The objective of this study is to evaluate the safety and hemostatic effectiveness of the Fibrin Pad (FP) versus standard of care treatment (SoC) in controlling challenging severe soft tissue bleeding during abdominal, pelvic…
- Trial name
- NCT00977925
- Testing
- Fibrin Pad, Standard of Care
- Where
- 17 sites in Australia, Germany and 2 more
- Volunteers
- 91 people
- Sponsor
- Ethicon, Inc.
Non-valvular Atrial Fibrillation
A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.
Using mandatory nationwide registries and possibly hospital electronic medical records in Norway, the researchers want to understand how well a group of drugs called "non-vitamin K antagonist oral anticoagulants" (rivaroxaban …
- Trial name
- PROTECT-AF (NCT03715725)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Apixaban (Eliquis), Dabigatran etexilate (Pradaxa)
- Where
- Norway
- Volunteers
- 70,000 people
- Sponsor
- Bayer
Trauma, Haemorrhage
Fibrinogen Early In Severe Trauma studY
Haemorrhage in severe trauma is a significant cause of mortality and is potentially the most preventable cause of death in trauma patients Trauma Induced Coagulopathy (TIC) is a complex coagulopathy associated with severe trauma…
- Conditions
- Trauma, Haemorrhage, Coagulopathy
- Trial name
- FEISTY (NCT02745041)
- Testing
- Fibrinogen Concentrate, Cryoprecipitate
- Where
- 4 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Gold Coast Hospital and Health Service
Pulmonary Arterial Hypertension
Bleeding Frequency Under Anticoagulant Treatment in Pulmonary Hypertension
Pulmonary hypertension (PHT) patients often receive long term oral anticoagulants. If the indication is strong, in the secondary chronic thrombo-embolism pulmonary hypertension (CTE-PHT) prevention, the frequent prescription (50…
- Trial name
- HEMA-HTP (NCT02800941)
- Testing
- Oral anticoagulant treatment
- Where
- 4 sites in France
- Volunteers
- 203 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Severe Traumatic Brain Injury, Subarachnoid Hemorrhage
Cortical Excitability in Patients With Severe Brain Injury
The aim of the study is to evaluate the cortical excitability in the severe brain injured patients. We hypothesize that: 1. There is a continuous decrease in intracortical inhibition from healthy subjects to awake patients with…
- Conditions
- Severe Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00788723
- Testing
- Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hemophilia and Other Severe Bleeding Disorders
Swiss Hemophilia Registry
The Swiss Hemophilia Registry will collect data on the prophylactic and therapeutic use of factor concentrates in patients with hemophilia and other severe bleeding disorders in Switzerland.
- Trial name
- NCT02512250
- Testing
- Registry
- Where
- 19 sites in Switzerland
- Volunteers
- 900 people
- Sponsor
- Swiss Hemophilia Network
Thoracic Surgery, Vascular Injury
Major Vascular Injuries in Elective Thoracic Surgery: A 10-Year Single-Center Experience
This study retrospectively examines major vascular injuries that occurred during elective thoracic surgeries over a 10-year period at a single tertiary care center.
- Conditions
- Thoracic Surgery, Vascular Injury, Intraoperative Complications
- Trial name
- NCT07100509
- Testing
- Major Vascular Injury During Elective Thoracic Surgery
- Volunteers
- 11 people
- Sponsor
- Caner İşevi, MD
Congenital Bleeding Disorder, Haemophilia A
A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A
Investigating single dose pharmacokinetics and safety of turoctocog alfa pegol from the pivotal process and turoctocog alfa pegol from the commercial process in patients with severe haemophilia A
- Trial name
- pathfinder™7 (NCT02920398)
- Testing
- turoctocog alfa pegol
- Where
- 14 sites in United States, Denmark and 4 more
- Volunteers
- 21 people
- Sponsor
- Novo Nordisk A/S
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Anemia, Iron Deficiency, Uterine Bleeding
IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department
The primary aim of this randomized trial is to assess the efficacy of IV Ferric Derisomaltose vs Oral Iron in the management of women with severe Iron Deficiency Anemia due to Uterine Bleeding in the emergency department.
- Trial name
- NCT05304442
- Testing
- Ferric Derisomaltose 1000 Mg in 10 mL INTRAVENOUS SOLUTION [Monoferric], Ferrous Sulfate 65 mg elemental iron (325 mg tablets)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Severe Hemophilia A
Post Approval Phase 4 Study to Learn More About How Safe Octocog Alfa is, and How Well it Works in Patients With Severe Hemophilia A in India
Hemophilia A is a genetic condition that makes it hard for blood to clot properly. This happens because the body does not have enough of a protein called Factor VIII, which helps stop bleeding.
- Trial name
- HEMOCT INDIA (NCT07446010)
- Testing
- Octocog alfa
- Volunteers
- 30 people
- Sponsor
- Bayer
Intracranial Hemorrhages, Prematurity
Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event.
- Trial name
- NCT00817310
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Primary Immune Thrombocytopenia
Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia
This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP).
- Trial name
- NCT05070845
- Testing
- PF-06835375
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
Hemophilia A
UPLC-MS/MS Monitoring of Emicizumab Therapy
Emicizumab is a monoclonal bispecific antibody with a terminal half-life of 28 days which is now licensed in the treatment of severe haemophilia A with or without inhibitors.
- Trial name
- EMICARE (NCT04472169)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Trauma
Rotational Thromboelastometry Activated Transfusion In Trauma Trial
This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of blood products, effects on coagulation and…
- Trial name
- ROTATE-IT (NCT03765866)
- Testing
- Thromboelastometry guided transfusion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
Bleeding Disorder
Recombinant vWF Concentrate and ECMO
Adult patients on extracoporeal membrane oxygenation (ECMO) frequently experience bleeding, which is in part caused by acquired von Willebrand syndrome (vWS).
- Trial name
- NCT06118372
- Testing
- Recombinant von Willebrand Factor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Adult Patient Undergoing Major Surgery
Evaluation of the Accuracy and Precision of the Masimo Labs Pulse-Hemoglobin-Meter Monitor in Surgical Patients
The Masimo monitor can measure hemoglobin level noninvasively and accuratly
- Trial name
- NCT00762398
- Testing
- Masimo hemoglobin-meter, drawing blood sample
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Uterine Hemorrhage
A Study of Severe Uterine Bleeding Following Exposure to Direct Oral Anticoagulants
The purpose of this study is assess the: (a) incidence of severe uterine bleeding (SUB) following exposure to individual direct oral anticoagulant (DOACs) (rivaroxaban, apixaban, dabigatran) and warfarin, (b) individual DOACs…
- Trial name
- NCT04394234
- Testing
- Direct oral anticoagulant (DOACs), Warfarin
- Where
- United States
- Volunteers
- 961,985 people
- Sponsor
- Janssen Research & Development, LLC
Major Trauma, Traumatic Brain Injury
Severe Trauma Registry in Tarragona
Severe trauma is one of the leading causes of morbidity, mortality, and disability worldwide. Currently, it is the primary cause of death among individuals under 45 years of age.
- Trial name
- IcuTrauma (NCT06007807)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.