Clinical trials: Major Depression, open to volunteers
Depression, HIV
Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in Nigeria
The goal of this clinical trial is to find out the usefulness and well-being of people when drugs for treating depression (fluoxetine) and HIV (dolutegravir) are used together.
- Trial name
- FLUDOPRESS (NCT07110831)
- Testing
- Fluoxetine, Cognitive-behavioral therapy
- Where
- Nigeria
- Volunteers
- 168 people
- Sponsor
- University of Ibadan
Depression - Major Depressive Disorder, Generalised Anxiety Disorder
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
The goal of this clinical trial is to learn if an internet-based Unified Protocol (iUP) intervention is effective for treating depression and anxiety disorders in Hong Kong young adults aged 18-29 years.
- Conditions
- Depression - Major Depressive Disorder, Generalised Anxiety Disorder, Anxiety Disorder (Panic Disorder or GAD), Depressive and Anxiety Disorders
- Trial name
- NCT07908628
- Testing
- Internet-based Unified Protocol (iUP), Waitlist Control Group
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Spinal Cord Injury, Depression - Major Depressive Disorder
Psilocybin to Treat Depression in Spinal Cord Injury
The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg).
- Conditions
- Spinal Cord Injury, Depression - Major Depressive Disorder, Veteran
- Trial name
- STOP (NCT07251491)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Major Depressive Diorder
Efficacy and Safety of DTMS in Adolescent Major Depressive Disorder
The goal of this randomized controlled trial is to explore the efficacy and safety of two different dTMS devices in adolescent depression: deep TMS H1 coil and deep TMS H7 coil.
- Trial name
- NCT06728280
- Testing
- deep transcranial magnetic stimulation with H1coil, deep transcranial magnetic stimulation with H7 coil
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Zhifen Liu
Depression, Major Depressive Disorder
Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD).
- Trial name
- RADIANT (NCT06976840)
- Testing
- Intermittent theta burst stimulation, Continuous theta burst stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Marta Peciña, MD PhD
Major Depression, Pregnancy
RCT of At-Home tDCS for Depression in Pregnancy
This is a randomized, sham-controlled trial to determine whether treatment with transcranial direct current stimulation (tDCS) is superior to a sham condition at reducing the symptoms of depression in pregnant people with…
- Conditions
- Major Depression, Pregnancy, Postpartum Depression
- Trial name
- NCT05097586
- Testing
- active tDCS, workbook
- Where
- 2 sites in Canada
- Volunteers
- 156 people
- Sponsor
- Women's College Hospital
Major Depressive Disorder
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression
Background and Rationale With rapid economic development and increasing societal pressures, the incidence of neuropsychiatric disorders has risen annually, ranking as the leading cause of disability worldwide and imposing a…
- Trial name
- NCT07775586
- Testing
- rTMS-Tiny Treatment
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder (MDD) With Insomnia
Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia
Major Depressive Disorder (MDD) affects 5% of the global population and is the second leading cause of disability worldwide. Despite the widespread use of antidepressants, 50-60% of patients do not respond adequately after 8…
- Trial name
- CombiChronoS (NCT07120880)
- Testing
- AD + SHR + active LT and extended-release melatonin 2mg
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder (MDD), Depression in Adults
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD.
- Conditions
- Major Depressive Disorder (MDD), Depression in Adults, Depression - Major Depressive Disorder, Depression Disorders
- Trial name
- EMBRACE (NCT06793397)
- Testing
- CYB003, Psychological Support
- Where
- 79 sites in United States, Australia and 6 more
- Volunteers
- 330 people
- Sponsor
- Cybin IRL Limited
Depression - Major Depressive Disorder, Anxiety
Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer
The purpose of this randomized clinical trial is to study anxiety and depression symptoms at diagnosis in patients with colon cancer. Previous studies have shown that so-called.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Colon Cancer
- Trial name
- BAdepCa (NCT06745700)
- Testing
- Brief Behavioural Activation, Care as usual
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Västmanland
Major Depressive Episode (MDE), Beliefs
Belief Update: The Effects of Depression and Antidepressants in Older People
People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment…
- Conditions
- Major Depressive Episode (MDE), Beliefs, Beliefs About Future, Depression
- Trial name
- OLDBELIEFS (NCT07681492)
- Testing
- Response to questionnaire
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Generalized Anxiety Disorder (GAD), Major Depressive Disorder
Therapy and Tech Study
The investigators want to test if gen AI can support therapy by recruiting patients already in therapy.
- Trial name
- NCT07225192
- Testing
- Chatbot Therapy
- Volunteers
- 204 people
- Sponsor
- University of California, Irvine
Serious Mental Illness, Schizophrenia
Mindfulness-Based Therapy for Serious Mental Illness
Serious mental illness (SMI), encompassing schizophrenia-spectrum and major mood disorders, has been estimated to affect approximately 5.4% of the U.S. adult population each year.
- Conditions
- Serious Mental Illness, Schizophrenia, Major Depressive Disorder, Bipolar Disorder
- Trial name
- MBT (NCT06880796)
- Testing
- Mindfulness-based therapy, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Butler Hospital
Major Depressive Disorder, Suicidal Behavior
Basal Plasma Lithium Levels and Suicidal Events
Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk.
- Conditions
- Major Depressive Disorder, Suicidal Behavior, Bipolar Disorder
- Trial name
- LIPS (NCT05409794)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 158 people
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder, Dysthymic Disorder
Testing a Precision Psychotherapy System for Low-income Patients
The purpose of this study is to evaluate the feasibility of an evidence-based system to recommend core interventions, before the beginning of treatment, to psychotherapists treating low-income patients with depressive or anxiety…
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Specific Phobia, Social Anxiety Disorder
- Trial name
- ML_LMIC (NCT05118594)
- Testing
- Pre-treatment psychotherapy recommendations
- Volunteers
- 111 people
- Sponsor
- National Council of Scientific and Technical Research, Argentina
TBI (Traumatic Brain Injury), Depressive Disorder, Major
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
The purpose of this randomized controlled trial is to evaluate whether the InMotion intervention, delivered via telehealth (using a HIPAA-compliant video platform or phone), which uses evidence-based behavioral and motivational…
- Conditions
- TBI (Traumatic Brain Injury), Depressive Disorder, Major, Clinical Depression, Mood Depressed
- Trial name
- NCT06005194
- Testing
- InMotion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Major Depressive Disorder (MDD), IBNI617
Probiotic IBNI617 for Moderate to Severe Depression
IBNI617 is a live biotherapeutic product(LBP). This is a randomized, double-blind, placebo-controlled, parallel-group Phase II clinical trial to evaluate the efficacy and safety of IBNI617 in adult patients with major depressive…
- Trial name
- NCT07728253
- Testing
- Live biotherapeutic product
- Where
- China
- Volunteers
- 148 people
- Sponsor
- IBIOME BIOTECHNOLOGY CO., LTD
Patients With Major Depressive Disorder
Cognitive Behavior Therapy Among Patients With Major Depressive Disorder-Multiple Episodes.
The main purpose of this study to teach the patients how to manage their depression, generalized Anxiety symptoms, mental health seeking attitude, motivation and attitude toward changing health, to improve the quality of life…
- Trial name
- NCT07300527
- Testing
- Cognitive Behavior Therapy, treatment as usual (TAU) (Control Group)
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Major Depressive Disorder
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel.
- Trial name
- GATE-251 (NCT06547489)
- Testing
- Zelquistinel
- Where
- 34 sites in United States
- Volunteers
- 164 people
- Sponsor
- Syndeio Biosciences, Inc
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier