Clinical trials: Major Depression
Depression, Unipolar
Whole-body Hyperthermia for Moderate to Severe Depressive Disorder
The primary aim of this study is to investigate the effectiveness of whole-body hyperthermia in addition to standard medical care in comparison to standard medical care alone on depressive symptom severity in patients with…
- Trial name
- HYPE2 (NCT03906149)
- Testing
- Whole-body hyperthermia + standard medical care, Standard medical care
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universität Duisburg-Essen
Depression, Anxiety
Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients
This is a prospective, randomized clinical trial to investigate the clinical impact of a preemptive pharmacogenomics strategy to guide antidepressant therapy in cancer patients.
- Conditions
- Depression, Anxiety, Generalized Anxiety Disorder, Depressive Disorder
- Trial name
- NCT03674138
- Testing
- DNA-guided choice of therapy, Clinical management
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Major Depressive Disorder (MDD)
Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
This study will look at how a new medication (dextromethorphan and bupropion taken together in one pill) affects the brain in people with depression.
- Trial name
- NCT07523048
- Testing
- Dextromethorphan-Bupropion
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Roger McIntyre
Schizophrenia, Major Depression
A Double Blind Sham Controlled Trial of tDCS in Treating Schizophrenia and Depression
The project will investigate the use of a novel technique, transcranial direct current stimulation (tDCS) in the treatment of patients with schizophrenia and patients with depression.
- Trial name
- NCT00481026
- Testing
- transcranial direct current stimulation (tDCS), active tDCS
- Where
- Australia
- Volunteers
- 31 people
- Sponsor
- Bayside Health
Major Depressive Disorder, Depression
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
The goal of this fixed order, open-label, dose-escalation study is to investigate the safety and efficacy of specific doses of dimethyltryptamine (DMT) in humans.
- Trial name
- NCT04711915
- Testing
- 0.1 mg/kg Dimethyltryptamine (DMT), 0.3 mg/kg Dimethyltryptamine (DMT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression
Study of Methylphenidate as Add on Therapy in Depressed Cancer Patients
Primary Objective To determine the efficacy of Methylphenidate as add on therapy to mirtazapine in the treatment of depression in cancer patients under palliative care Hypothesis Methyphenidate add on to mirtazapine treated…
- Trial name
- NCT01497548
- Testing
- Methylphenidate
- Where
- 2 sites in Malaysia
- Volunteers
- 120 people
- Sponsor
- University of Malaya
Anxiety Disorders, Social Anxiety Disorder
Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing Problems
To investigate the efficacy and mechanisms of change of an Internet-delivered transdiagnostic REBT intervention for adolescents with internalizing problems.
- Conditions
- Anxiety Disorders, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- REBTonAd (NCT04179526)
- Testing
- Transdiagnostic Internet-delivered REBT
- Where
- Romania
- Volunteers
- 106 people
- Sponsor
- Babes-Bolyai University
Depression
Brain Markers of Depression Vulnerability: the Case of Prefrontal Haemodynamic Response
Functional near infrared spectroscopy (fNIRS) offers a cheap and reliable tool to investigate prefrontal brain activation in the healthy and diseased human brain.
- Trial name
- NCT05427578
- Testing
- fNIRS measurement
- Where
- Hong Kong
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr Georg Kranz
Major Depressive Disorder 1
Cultural Adaptation of EMDR for Major Depressive Disorder and Compaire Its Online and Face-to-Face Testing
The present study aims to develop a culturally and methodologically adapted EMDR therapy protocol, determine its treatment fidelity, and then clinically test its efficacy in the treatment of Major Depressive Disorder in Pakistan…
- Trial name
- EMDR (NCT06439043)
- Testing
- EMDR Psychotherapy, Online EMDR Psychotherapy
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Covid19, Depression
Depression and Anxiety in Long Term Coronavirus Disease COVID-19
Background : Depression and Anxiety are linked to COVID (Coronavirus Disease)-19 long-term impact through several mechanisms. The possible way is the alteration of neurotransmitter regulation from the interaction of severe acute…
- Conditions
- Covid19, Depression, Anxiety
- Trial name
- DALT-COV (NCT04893668)
- Testing
- Depression, Anxiety
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Major Depressive Disorder, Dysthymia
L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response.
- Conditions
- Major Depressive Disorder, Dysthymia, Depression
- Trial name
- NCT03761030
- Testing
- L-DOPA
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety, and tolerability of Levomilnacipran ER fixed doses versus placebo in the treatment of outpatients with major depressive disorder.
- Trial name
- NCT00969709
- Testing
- Levomilnacipran ER
- Where
- 38 sites in United States
- Volunteers
- 724 people
- Sponsor
- Forest Laboratories
Depression, Major Depressive Disorder
Integrated Chronotherapy for Perinatal Depression
Perinatal depression is a common and serious mood disorder that increases morbidity and mortality in new mothers and results in poor infant/child outcomes.
- Conditions
- Depression, Major Depressive Disorder, Postpartum Depression
- Trial name
- NCT02053649
- Testing
- Triple Chronotherapy, Usual Care
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rhode Island Hospital
Depressive Disorder, Major, Depression, Bipolar
Optimal Electrical Stimulus During Electroconvulsive Therapy
Synopsis Aim: The purpose of the study is to determine the stimulus of electrical current during electroconvulsive therapy (ECT) that produces the optimal balance between antidepressant effect and memory disturbance.
- Trial name
- NCT04057378
- Testing
- Electroconvulsive therapy
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Region Örebro County
Major Depressive Disorder
Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity
This 26-week long, double-blinded randomized clinical trial aims to investigate the effects of semaglutide once-weekly vs. placebo on depressive symptoms in 116 patients with Major Depressive Disorder (MDD) and co-existing…
- Trial name
- SEMAMOOD (NCT07136714)
- Testing
- Semaglutide Injectable Product
- Where
- Denmark
- Volunteers
- 116 people
- Sponsor
- Nordsjaellands Hospital
Depression
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression.
- Trial name
- NCT00498706
- Testing
- Telephone-administered cognitive behavioral therapy (T-CBT), Face-to-face administered CBT (FtF-CBT)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Subjects Had Unipolar, Non-psychotic Major Depression
Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression
Atypical neuroleptics may have antidepressant qualities in bipolar depression and in unipolar depression. Some data support the use of both Risperidone and Olanzapine, but there are no direct comparisons of their relative…
- Trial name
- NCT01282632
- Testing
- Risperidone, Olanzapine
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Sunnybrook Health Sciences Centre
Human Immunodeficiency Virus, Neurocognitive Impairment
Brain Imaging for HIV-Associated Thinking and Mood Disorders
Background: Human immunodeficiency virus (HIV) infection appears to cause problems with blood vessel function. These problems may add to some thinking and mood disorders found in people with HIV infection.
- Trial name
- NCT01692236
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Major Depressive Disorder
Pilot Study of Duloxetine in Psychological Resilience
The purpose of this study is to explore benefits of duloxetine in enhancing psychological resilience and to understand the relevance of inhibiting of both serotonin (5HT) and norepinephrine (NE)to therapeutic responses.
- Trial name
- NCT00331799
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Major Depressive Disorder, Treatment Resistant Depression
Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression
We propose a clinical study of medial forebrain bundle DBS as a treatment in 20 patients with treatment refractory depression (TRD).
- Trial name
- NCT02046330
- Testing
- Deep Brain Stimulation Model 3387 Model 3389
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston