Clinical trials: Major Depression Moderate
Depression
Shortened Depression Assessment Study
Participants will be asked to fill out an online questionnaire about their demographics information and all 42 items from the Depression Anxiety Stress Scale (DASS-42).
- Trial name
- NCT05123794
- Where
- Canada
- Volunteers
- 39,000 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Patients With Moderate to Severe Pain Requiring Analgesic Medications
Observation and Study on the Application of Different Analgesic Regimens in Critically Ill Patients Without Mechanical Ventilation
Pain management is a common treatment measure in the Intensive Care Unit (ICU). Due to their underlying diseases and invasive treatments, patients often experience discomfort and pain, leading to agitation, unplanned extubation…
- Trial name
- NCT07031453
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Major Depressive Disorder
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
X-NOVA3 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of azetukalner as a monotherapy in adult participants diagnosed with Major…
- Trial name
- X-NOVA3 (NCT07076407)
- Testing
- Azetukalner
- Where
- 50 sites in United States, Finland and 5 more
- Volunteers
- 450 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Depression, Depression Moderate
Outcomes Associated With Suicidality in Inpatients With Symptoms of Depression (OASIS-D)
This 6-month, naturalistic cohort study examines male and female inpatients aged 18 to 75 years i) with any form of unipolar depressive episode (cohort 1); ii) clinical diagnosis of a moderate or severe unipolar depressive…
- Conditions
- Depression, Depression Moderate, Depression Severe, Suicidal and Self-injurious Behavior
- Trial name
- OASIS-D (NCT04404309)
- Where
- Germany
- Volunteers
- 3,331 people
- Sponsor
- Charite University, Berlin, Germany
Major Depressive Disorder (MDD)
A Phase 2 Study to Evaluate Efficacy and Safety of KH607 Tablets in Adult Participents With Major Depressive Disorder
This is a two-part (open-label followed by double-blind) study evaluating the safety, tolerability, pharmacokinetics, and efficacy of KH607 in 120 participants diagnosed with moderate or severe Major Depressive Disorder.
- Trial name
- NCT07101120
- Testing
- KH607 tablets
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Depression Mild, Depression Moderate
Treating Major Depression With Yoga Mono-therapy
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria…
- Trial name
- NCT06091527
- Testing
- Yoga practice, Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, San Francisco
Major Depression Moderate, Major Depression Severe
EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in older age patients diagnosed with Major Depressive Episode, Major Depression, and Bipolar Disorder…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07740694
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Depressive Disorder
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy
Ketamine has been used successfully as the sole medication for anesthesia in the setting of electroconvulsive therapy (ECT), and has more recently been studied as an adjunct agent in combination with propofol (the most commonly…
- Trial name
- NCT02579642
- Testing
- Ketamine
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Alberta
Depression, Unipolar, Depression Moderate
The Cerebral and Cognitive Changes After Intermittent Theta Burst Stimulation (iTBS) Treatment for Depression
The present project aims to assess the neurocognitive impact of a two-week once-a-day regimen of intermittent theta burst stimulation (iTBS) compared to sham iTBS, when targeting the left dorsolateral prefrontal cortex (LDLPFC)…
- Trial name
- NCT06534684
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
Depression, Anxiety
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing symptoms of depression and anxiety will receive one dose of either a drug…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT06820723
- Testing
- CYB003
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Depression
A Study of the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression
The purpose of this study is to evaluate the Effectiveness and Safety of JS1-1-01 in Patients With Moderate to Severe Depression
- Trial name
- NCT06259526
- Testing
- JS1-1-01 low-dose group, JS1-1-01 high-dose group, Active drug group
- Where
- 17 sites in China
- Volunteers
- 267 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd