Clinical trials: Major Depressive Disorder, completed
Suicidal Ideation, Major Depressive Disorder
Adaptation of Dialectical Behavior Therapy Skills-Groups for Individuals With Suicidal Ideation and Depression
Harley and colleagues demonstrated that adding Dialectical Behavior Therapy (DBT) skills-groups and therapist consultation to treatment as usual successfully reduced symptoms of depression.
- Trial name
- NCT01441258
- Testing
- Dialectical Behavior Therapy Skills (DBT-S) Groups, Wait List-Treatment as Usual, No intervention-treatment as usual
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Maurizio Fava, MD
Seasonal Affective Disorder (SAD), Winter Depression
Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence
Major depression is a highly prevalent, chronic, and debilitating mental health problem with significant social cost that poses a tremendous economic burden.
- Conditions
- Seasonal Affective Disorder (SAD), Winter Depression, Major Depressive Disorder, Recurrent, With Seasonal Pattern
- Trial name
- NCT01714050
- Testing
- Cognitive-Behavioral Therapy (CBT), Light Therapy (LT)
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Vermont
Major Depressive Disorder
A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)
The investigators will be looking at MAO-A density before and after seven weeks of treatment with an antidepressant and dietary supplement. MAO-A is an enzyme that breaks down brain chemicals that regulate mood.
- Trial name
- NCT02269540
- Testing
- Sertraline, Citalopram, N-acetylcysteine (NAC)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Depressive Disorder, Major
The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopy
This study evaluates the activation on prefrontal cortex with acupuncture and moxibustion for major depressive disorder.Half of participants will receive the treatment of acupuncture and moxibustion, while the other participants…
- Trial name
- ACUfNIRS (NCT04272476)
- Testing
- acupuncture and moxibustion, Fluoxetine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Major Depressive Disorder, Psychotic Disorders
A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00130676
- Testing
- Mifepristone
- Where
- 23 sites in United States
- Volunteers
- 257 people
- Sponsor
- Corcept Therapeutics
Treatment Resistant Depression, Major Depressive Disorder
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate a short-term treatment option for major depressive disorders by administering nitrous oxide gas.
- Trial name
- SMILE (NCT04957368)
- Testing
- Nitrous Oxide 99 %, Oxygen + Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Glutamate Probes in Adolescent Depression
The purpose of this study is to learn if measures of brain chemicals from a brain scan called Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) and brain activity (known as cortical excitability and inhibition) collected by…
- Conditions
- Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
- Trial name
- GPII (NCT02307617)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Major Depression
Brain Abnormalities in Late-Onset Major Depression
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging…
- Trial name
- NCT00260468
- Testing
- Clinical examination program
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Depressive Symptoms
Physical Exercise and Depressive Symptoms in Moderately or Severely Depressed Adults
This study is a comparative trial comparing the time course of depressive symptoms between moderately and severely depressed participants over a 10-week long exercise program
- Trial name
- EXIMOS (NCT05703776)
- Testing
- Nordic Walking
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Je Bouge Pour Mon Moral
Depressive Disorder, Major, Depression
Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder
Evidence exists supporting the ability of genetic variations to influence patient drug response and side effects. Previous studies utilizing an open-label design have shown significant improvement in major depressive disorder…
- Conditions
- Depressive Disorder, Major, Depression, Depressive Disorder
- Trial name
- NCT02466477
- Testing
- GeneSight Psychotropic (GEN), Enhanced-GeneSight Psychotropic (E-GEN), Treatment as Usual (TAU)
- Where
- 14 sites in Canada
- Volunteers
- 542 people
- Sponsor
- Assurex Health Inc.
Major Depressive Disorder
Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression Disorder
Assessing psychiatric and physiological co-morbidity in TRD and non-TRD patients
- Trial name
- NCT00229398
- Sponsor
- Sheba Medical Center
Major Depressive Disorder(MDD)
Efficacy of Clinical Application of Transcranial Low Intensity Focused Ultrasonic Stimulation for Patients With Major Deperessive Disorder - Exploratory Clinical Trial
The non-invasive type ultrasonography system is applied to patients with major depressive disorder to evaluate their effectiveness and safety.
- Trial name
- NCT04405791
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Gangnam Severance Hospital
Major Depressive Disorder
Feasibility of a Behavioral Activation Trial
The goal of this project is to train community mental health therapists in behavioral activation (BA) treatment for major depressive disorder and then to conduct a study examining the feasibility of evaluating the effectiveness…
- Trial name
- NCT02992158
- Testing
- behavioral activation, treatment-as-usual
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Mood Disorders, Bipolar Disorder
Technology Enhanced Family Treatment
The investigators propose to enhance the scalability of family-focused therapy (FFT), a 12-session evidence-based therapy for youth at high risk for mood disorders, through augmentation with a novel mobile phone application…
- Conditions
- Mood Disorders, Bipolar Disorder, Major Depression
- Trial name
- NCT03913013
- Testing
- Family-Focused Treatment with MCC App
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder, Healthy Controls
Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets
The study is investigating dysfunctions in neurocircuitry in regards to irritability with healthy controls (HC) and individuals with Major Depressive Disorder (MDD) by performing MRIs.
- Trial name
- UNIKET (NCT05046184)
- Testing
- Ketamine Hydrochloride, Midazolam injection
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Depressive Disorders
Acute, Affective, Organic Disorders.
The purpose of the study is to investigate whether patients with brief depressive periods together with other fluctuating psychiatric symptoms, have this condition due to epilepsy or an other organic brain disorder.
- Trial name
- NCT00201474
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- Norwegian University of Science and Technology
Major Depressive Episode, Major Depressive Disorder
Depression-Reduction by Accelerated Personalized NeuroModulation and Its Effects on Sleep
Advances in repetitive transcranial magnetic stimulation (rTMS) protocols with intermittent theta-burst stimulation (iTBS) have significantly decreased the duration for one single session and thereby enabled accelerated treatment…
- Conditions
- Major Depressive Episode, Major Depressive Disorder, Borderline Personality Disorder
- Trial name
- DREAMS (NCT04832750)
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Oldenburg
Depression
fMRI Studies of Emotional Brain Circuitry in People With Major Depression
This study will examine activation of a brain circuit that regulates emotion in depressed patients before and after treatment to see which areas of the brain are involved in chronic depression.
- Trial name
- NCT00749125
- Testing
- Lexapro
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder
Study of Intravenous NRX-1074 in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy and safety of NRX-1074 following a single intravenous dose in subjects with major depressive disorder.
- Trial name
- NCT02067793
- Testing
- NRX-1074 1 mg, NRX-1074 5 mg, NRX-1074 10 mg
- Where
- 12 sites in United States
- Volunteers
- 151 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Depressive Symptoms, Remited Major Depressive Disorder
Cognitive Control Emotion Training to Prevent Major Depression in Youth At-Risk
The goal of this clinical trial is to learn if intervention of positive emotion working memory (PEWM), or negative emotion working memory (NEWM), or positive attention bias training (PABT) can prevent major depressive disorder…
- Trial name
- CTE 2019 (NCT04346784)
- Testing
- positive emotion working memory(PEWM) training, negative emtion working memory(NEWM) training, PABT
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Hunan Normal University
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