Clinical trials: Major Depressive Disorder, completed
Depression - Major Depressive Disorder
Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Hoa
This study aimed to evaluate whether the 8-week BA group therapy delivered at commune health stations (CHSs) improves depressive symptom severity, psychological distress, behavioral activation, resilient coping, and…
- Trial name
- not yet (NCT07527312)
- Testing
- Behaviral activation group therapy
- Where
- Vietnam
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Major Depressive Disorder
Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression
The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD)
- Trial name
- NCT06419608
- Testing
- BHV-7000
- Where
- 62 sites in United States
- Volunteers
- 336 people
- Sponsor
- Biohaven Therapeutics Ltd.
MDD
Effect of Magnesium Supplementation in Selective Serotonin Reuptake Inhibitors Treated Major Depressive Disorder Patients
A randomized, double-blind, placebo-controlled trial was conducted to assess the effect of magnesium glycinate on symptoms of moderate to severe depression in 90 patients.
- Trial name
- NCT04880460
- Testing
- Magnesium Glycinate tablet 200mg
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Major Depressive Disorder
Identifying Biological Markers for Severe Depression
The primary objective of this study is to investigate the biological components of major depression. The investigators are particularity interested in genetic variation and how it contributes to cortisol (because cortisol is…
- Trial name
- NCT01831882
- Where
- 3 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Stanford University
Major Depressive Disorder
Transcranial Direct Current Stimulation in Major Depression
Noninvasive transcranial direct current stimulation (tDCS) is a low-intensity neuromodulation technique of minimal risk that has been used as an experimental procedure for reducing depressive symptoms and symptoms of other brain…
- Trial name
- NCT03556124
- Testing
- Active - HD tDCS, Active - Conventional tDCS
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder (MDD)
Add-On Study of MSI-195 (S-Adenosyl-L-Methionine, SAMe) for Patients With Major Depressive Disorder (MDD)
The purpose of this study is to determine the efficacy and safety of 800 mg MSI-195 in reducing symptoms of depression in Major Depressive Disorder (MDD)patients with inadequate response to current antidepressant therapy.
- Trial name
- NCT01912196
- Testing
- MSI-195
- Where
- 35 sites in United States
- Volunteers
- 376 people
- Sponsor
- MSI Methylation Sciences, Inc.
Major Depressive Disorder
A Study of Aripiprazole in Patients With Major Depressive Disorder
The purpose of this 14 week, randomized, double-blind, placebo controlled study is to assess the safety and efficacy of aripiprazole to placebo as adjunctive treatment to an assigned open-label marketed antidepressant therapy…
- Trial name
- NCT00105196
- Testing
- Aripiprazole+ ADT
- Where
- 34 sites in United States
- Volunteers
- 349 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression, Bipolar Disorder
Predictors of Response to Augmentation With Ziprasidone (Geodon®) in Major Depressive Disorder
The primary outcome of this study is to determine if predictors of response can select a population of patients with MDD that is effectively treatable by augmentation with ziprasidone.
- Trial name
- NCT01168674
- Testing
- ziprasidone, Sugar pill
- Volunteers
- 49 people
- Sponsor
- Tufts Medical Center
Depression, Involutional
Neurocardiac Control in Major Depression
This study will examine how depression may influence the way the brain regulates heart function. Some researchers believe that depression may be a risk factor for some forms of heart disease.
- Trial name
- NCT00084162
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode
The study is a phase II, double-blind, randomized, placebo controlled, parallel, multicentric study in 110 patients with drug resistant depression.
- Trial name
- NCT03870776
- Testing
- MAP4343
- Where
- 10 sites in France
- Volunteers
- 126 people
- Sponsor
- Mapreg
Depressive Disorder, Major, Menopause
Estrogen and Perimenopausal Depression
During perimenopause (the time just prior to menopause), women often notice many biological, psychological, and social changes. In particular, some women experience depressive symptoms during perimenopause that are severe enough…
- Trial name
- NCT00229450
- Testing
- Estrogen
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Panic Disorder, Posttraumatic Stress Disorder
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder
The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD).
- Conditions
- Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025974
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
Family Cognitive Behavioral Therapy for Preventing Depression in Children
This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression.
- Trial name
- NCT00183482
- Testing
- Family Group Cognitive Behavioral, Written Information
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Vanderbilt University
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
To compare the antidepressant efficacy and safety of subjects receiving DVS-233 SR versus subjects receiving placebo.
- Trial name
- NCT00072774
- Testing
- DVS-233 SR
- Volunteers
- 480 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder
Brief Behavioral Therapy for Insomnia (bBT-I) for Depressed Outpatients With Refractory Insomnia
The purpose of this study is to examine the effectiveness of brief behavioral therapy for insomnia (bBT-I) in addition to treatment as usual (TAU) in comparison with TAU alone for refractory insomnia among patients with major…
- Trial name
- NCT00610259
- Testing
- brief behavioral therapy for insomnia (bBT-I), Treatment as usual (TAU)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Nagoya City University
Depressive Disorder, Major
A Safety Study in Participants With Major Depressive Disorder
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to…
- Trial name
- NCT01155661
- Testing
- LY2216684 (edivoxetine), SSRI
- Where
- 48 sites in United States, Brazil and 5 more
- Volunteers
- 608 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Long-Term Administration Study of Aripiprazole as an Adjunctive Therapy in Patients With Major Depressive Disorder
To examine the safety and efficacy of long term administration of aripiprazole as an adjunctive therapy, co-administered with either a selective serotonin reuptake inhibitor (SSRI) or a selective-norepinephrine reuptake inhibitor…
- Trial name
- NCT00882362
- Testing
- OPC-14597 (Aripiprazole)
- Where
- 8 sites in Japan
- Volunteers
- 155 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Depression
Using Functional MRI Neurofeedback to Modulate Self-blame in Major Depressive Disorder
To determine the feasibility of functional MRI neurofeedback in reducing overgeneralised self-blame in patients with depression
- Trial name
- NCT05455827
- Testing
- fMRI neurofeedback (A), fMRI neurofeedback (B)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Brighton & Sussex Medical School
Major Depressive Disorder
Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder
Therapeutic latency, lack of efficacy, and adverse drug reactions are the major concerns in current antidepressant therapies. One-third of the patients with major depressive disorder do not respond to conventional antidepressants…
- Trial name
- NCT05181527
- Testing
- Selective Serotonin Reuptake Inhibitors, Dextromethorphan
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-066)(COMPLETED)
A clinical study to determine the efficacy and safety of an investigational medication (MK0869) in the treatment of depression
- Trial name
- NCT00034983
- Testing
- aprepitant, Comparator: paroxetine HCL
- Volunteers
- 900 people
- Sponsor
- Merck Sharp & Dohme LLC
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