Clinical trials: Major Depressive Disorder, completed
Major Depressive Disorder
Venlafaxine ER Phase 3 Study for Major Depressive Disorder (MDD)
This is a phase 3, multi-center, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of venlafaxine ER 75 mg/day (fixed dose) and venlafaxine ER 75 mg/day to 225 mg/day (flexible…
- Trial name
- NCT01441440
- Testing
- venlafaxine ER 75 mg/day (fixed dose), venlafaxine ER 75 mg/day to 225 mg/day (flexible dose)
- Where
- 63 sites in Japan
- Volunteers
- 538 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Mild Cognitive Impairment, Major Depressive Disorder
Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment
Alzheimer's disease (AD), the most common dementing disorder of later life, is a major cause of disability and death in the elderly. Although a number of theoretical causes exist, the etiology of AD is still unknown.
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Disease
- Trial name
- NCT01876823
- Testing
- es-citalopram, Memantine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Stress and the Sympathetic Nervous System in Adults With Depression
To test our hypotheses, we will enroll healthy adults having no history of mood disorders and adults with major depressive disorder (MDD) having a broad range of depressive symptom severity.
- Trial name
- NCT04838262
- Testing
- Acute Stressors
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Treatment Resistant Depression, Electroconvulsive Therapy
ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real world setting with patient reported outcomes as…
- Conditions
- Treatment Resistant Depression, Electroconvulsive Therapy, ECT, Ketamine
- Trial name
- ELEKT-D (NCT03113968)
- Testing
- electroconvulsive therapy (ECT), Ketamine
- Where
- 5 sites in United States
- Volunteers
- 403 people
- Sponsor
- Bo Hu
Depression, Major Depressive Disorder
The Treatment of Depression With Yoga and Walking
This randomized controlled trial is designed to test the Vagal-gamma amino-butyric acid (GABA) Hypothesis that one of the mechanisms by which yoga-based practices improve mood and decrease anxiety is by correcting an autonomic…
- Conditions
- Depression, Major Depressive Disorder, PTSD, Anxiety
- Trial name
- NCT02907476
- Testing
- Iyengar Yoga, Walking
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Boston University
Bipolar Disorder, Bipolar I Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
- Conditions
- Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression
- Trial name
- NCT03336918
- Testing
- Lithium
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
fMRI Study of tES in Major Depression
This is a functional MRI study that will examine the effects of noninvasive transcranial electrical stimulation (tES) on brain function in individuals with Major Depression.
- Trial name
- NCT04031547
- Testing
- Transcranial Electrical Stimulation (tES)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwestern University
Major Depressive Disorder
MemFlex to Prevent Depressive Relapse
A wealth of research has demonstrated that they way in which the investigators recall our personal, autobiographical memories is influential in the course of depression.
- Trial name
- NCT02614326
- Testing
- Autobiographical Memory Flexibility (MemFlex) training, Psychoeducation
- Where
- 2 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Major Depressive Disorder (MDD)
Improving Depression Outcome by Enhancing Memory for Cognitive Therapy
Existing drug and talking therapies for major depressive disorder (MDD) fail to produce complete recovery. This study will determine if substantial improvements to one of the most promising therapies, cognitive therapy (CT), can…
- Trial name
- NCT01790919
- Testing
- Cognitive therapy for depression
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, Berkeley
Major Depressive Disorder, Anhedonia
Dopamine Neurotransmission in Major Depression
The overall aim of this study is to utilize an integrative research model in order to dynamically assess reward-related dopamine (DA) transmission in major depressive disorder (MDD) and test the role of dysfunctional DA release…
- Trial name
- NCT01659814
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder
Aripiprazole (Abilify®) as an Adjunctive Treatment for Inadequate Response in Major Depressive Disorder
The investigators hypothesized that combined pharmacotherapy using adjunctive aripiprazole of standard antidepressants would be associated with improved depression response in Major depressive disorder, especially in Quality of…
- Trial name
- NCT01696617
- Testing
- Aripiprazole 6-week group, Aripiprazole 8-week group
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital
Depression
MRI-Guided High-Definition Transcranial Direct Current Stimulation (tDCS) for Depression
The purpose of this research is to understand how a neurostimulation technique, transcranial electrical stimulation (tES), affects brain function in adults with major depression measured with functional magnetic resonance imaging…
- Trial name
- NCT05090397
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Northwestern University
Depression, Depressive Disorder, Major
Sleep, Wake and Light Therapy for Depression
The aim of this study is to determine if altering the pattern of one's sleep and having light therapy can speed up the treatment of depression.
- Conditions
- Depression, Depressive Disorder, Major, Depression, Unipolar, Depression Moderate
- Trial name
- NCT03405493
- Testing
- Wake and Light Therapy, Sleep and Light Therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Depressive Disorder, Major
Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy
The proposed study is a randomized, placebo-controlled, double-blind trial to evaluate the safety and efficacy of antidepressant combination for the treatment of depression.
- Trial name
- COATS (NCT00150839)
- Testing
- Mirtazapine, Venlafaxine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Major Depressive Disorder
Improving Therapeutic Learning in Depression: Proof of Concept
Despite advances in both pharmacotherapy and psychotherapy for major depression, non-response and partial-response remain relatively common outcomes, motivating the search for new treatments.
- Trial name
- NCT02376257
- Testing
- 250 mg DCS, 100 mg Modafinil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Boston University Charles River Campus
Treatment Resistant Depression, Major Depressive Disorder
Optimizing Outcomes of Treatment-Resistant Depression in Older Adults
The purpose of this research study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD).
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Treatment-Refractory Depression, Late Life Depression
- Trial name
- OPTIMUM (NCT02960763)
- Testing
- Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion
- Where
- 5 sites in United States, Canada
- Volunteers
- 742 people
- Sponsor
- Washington University School of Medicine
Post-Traumatic Stress Disorder
Bringing What Works to Youth in Corrections: A Trauma Intervention
Youth with mental illnesses are disproportionately represented in juvenile correctional facilities and limited evidence exists about effective treatments in this setting.
- Trial name
- NCT01560728
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States
- Volunteers
- 57 people
- Sponsor
- University of Texas at Austin
Major Depression
Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients
This is a pilot study. The purpose of this study is to determine whether adding 4 months of behavioral therapy to primary care physician medication treatment(relative to medication treatment alone) improves outcomes for…
- Trial name
- NCT00541957
- Testing
- behavior therapy, Medication prescribed by PCP
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
MDD
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment
To investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in active adults with MDD, 18 to 35 years old, who are experiencing an inadequate selective serotonin reuptake inhibitor (SSRI)/serotonin…
- Trial name
- NCT02013609
- Testing
- Brexpiprazole
- Where
- 24 sites in United States
- Volunteers
- 48 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.