Clinical trials: Major Depressive Disorder, completed
Depressive Disorder, Major, Bipolar Depression
Triple Chronotherapy in Adolescents
Study Purpose This study is a randomized controlled trial examining the effectiveness of TCT in the acute treatment of depression and suicidality in adolescents compared to usual treatment care, which includes individual and…
- Conditions
- Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
- Trial name
- TCT-RCT (NCT03679962)
- Testing
- Triple Chronotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Billings Clinic
Major Depressive Disorder
Study Evaluating DVS-233 SR In Adult Outpatients With Major Depressive Disorder
Primary Objective: To compare the efficacy and safety of DVS-233 SR versus placebo treatment in reducing the relapse rate of depressive symptoms in subjects with major depressive disorder (MDD), and to compare the percentages of…
- Trial name
- NCT00075257
- Testing
- DVS-233 SR
- Volunteers
- 603 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Major Depressive Disorder, Alcohol Use Disorder
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.
Mirtazapine is a non-SSRI (selective serotonin reuptake inhibitor) medication with a unique structure and mechanism of action. Recent study results suggest that mirtazapine may be more effective and faster acting than other…
- Trial name
- PT-MAD (NCT02185131)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Depressive Disorder, Major
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders
This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression.
- Trial name
- NCT00097175
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder (MDD)
Transcranial Magnetic Stimulation in Depression.
Major depressive disorder (MDD) has increased in recent years, affecting 16.1% of the adult population nationwide. Currently, there are pharmacological and psychological treatments that have a 67% remission rate for depressive…
- Trial name
- LiTMS (NCT07638202)
- Testing
- The experimental group(A) received conventional drug treatment combined with Li-TMS., control group B were administered standard drug therapy with coil placement, without exposure to Li-TMS emission.
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Mexicano del Seguro Social
Major Depressive Disorder
Efficacy of Trial-Based Cognitive Therapy and Behavioral Activation in Treatment of Depression
Major Depressive Disorder (MDD) is a mood disorder, highly prevalent in Brazil and in world. The treatments of choice are the psychotropic drugs of the class of antidepressants and Behavioral or Cognitive Behavior Therapy (CBT).
- Trial name
- NCT02624102
- Testing
- Trial based cognitive therapy, Behavioral Activation, Antidepressants
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Hemanny, Curt, M.D.
Major Depressive Disorder
Major Depressive Disorder With Mixed Features - Extension
Lurasidone HCl is a compound that is a candidate for the treatment of major depressive with mixed features.This clinical study is designed to test how well Lurasidone works to treat major depressive disorder with mixed features…
- Trial name
- RESOLVE3 (NCT01423253)
- Testing
- Lurasidone
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sumitomo Pharma America, Inc.
Major Depression
Long-term Bilateral Theta Burst Stimulation for the Treatment of Major Depression
Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may exert larger effects.
- Trial name
- TheBuS_D (NCT01153139)
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation, TBS)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- University Hospital Tuebingen
Pulmonary Disease, Chronic Obstructive, Major Depression
Treatment of Depressed Chronic Obstructive Pulmonary Disease Patients
Approximately 20% of patients with chronic obstructive pulmonary disease (COPD) have major depression, a condition that contributes to suffering but also to poor treatment adherence leading to increased disability and morbidity.
- Trial name
- NCT00151372
- Testing
- Treatment Adherence Intervention, Enhanced Care
- Where
- 3 sites in United States
- Volunteers
- 141 people
- Sponsor
- Weill Medical College of Cornell University
Major Depressive Disorder
The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder
Major depressive disorder (MDD) is highly prevalent, affecting nearly 4% of the global population. Pharmacotherapy is the frontline treatment recommended by the guideline, but it also has some limitations such as delayed onset…
- Trial name
- NCT05720637
- Testing
- SSRI, SIA, AIA
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xiaomei Shao
Major Depressive Disorder
Safety Study of Escitalopram in Children 7 to 11 Years of Age With Major Depressive Disorder
This study will evaluate the long-term safety and tolerability of escitalopram (Lexapro) in children 7 to 11 years of age with major depressive disorder (MDD).
- Trial name
- NCT01198795
- Testing
- Escitalopram
- Where
- 16 sites in United States
- Volunteers
- 162 people
- Sponsor
- Forest Laboratories
Depressive Disorder, Major
Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder
To evaluate the early onset of efficacy of vortioxetine 17 mg intravenously (IV) and vortioxetine 10 mg/day oral dose regimen versus placebo IV and vortioxetine 10 mg/day oral dose regimen on depressive symptoms
- Trial name
- NCT02919501
- Testing
- Vortioxetine (IV), Vortioxetine (tablet)
- Where
- 7 sites in Estonia, Finland
- Volunteers
- 55 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder, Depression Moderate
Exercise Recovery From Persistent Depression: A Thematic Analysis
Depression is a leading cause of disability worldwide and poses a large economic burden in the UK. There is evidence that exercise is beneficial in the management of depression and NICE now recommends group exercise programs as a…
- Conditions
- Major Depressive Disorder, Depression Moderate, Depression Severe
- Trial name
- NCT05539495
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Non-psychotic Unipolar Major Depression
Prevalence and Risk Factors in Unipolar Depression Patients Without Remission After One Antidepressant Trial
A non interventional, descriptive, longitudinal cohort study is designed, trying to obtain local data about the prevalence of non remitted depressed patients after an antidepressant treatment, and to get information about…
- Trial name
- PANTHER (NCT01887639)
- Where
- 8 sites in Argentina
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Depression, Anxiety
Symptom-specific TMS Targets for Depression and Anxiety
This pilot study aims to compare two different treatment targets for transcranial magnetic stimulation, an FDA-approved treatment for major depressive disorder (MDD), in terms of their relative efficacy for depression versus…
- Conditions
- Depression, Anxiety, Major Depressive Disorder
- Trial name
- NCT04604210
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Major Depressive Disorder
Study of Safety, Tolerability and Pharmacokinetics of NRX-1074 in Normal Healthy Volunteers
The purpose of this study is to assess the safety and tolerability of multiple oral (PO) ascending doses of NRX-1074 in normal healthy volunteers.
- Trial name
- NRX-1074 (NCT02366364)
- Testing
- NRX-1074 375 mg, NRX-1074 500 mg, NRX-1074 750 mg
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Depression, Postpartum, Postpartum Depression
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD).
- Conditions
- Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression
- Trial name
- NuMom (NCT06285916)
- Testing
- NORA520 Dose 1, NORA520 Dose 2
- Where
- 18 sites in United States
- Volunteers
- 93 people
- Sponsor
- TWi Biotechnology, Inc.
Major Depressive Disorder
Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis
This is a retrospective chart review study to determine if Deplin® 7.5mg-15mg combined with an antidepressant is better than an antidepressant alone in adults with major depression.
- Trial name
- NCT01001559
- Testing
- L-methylfolate, Selective serotonin reuptake inhibitor (SSRI), Serotonin and norepinephrine reuptake inhibitor (SNRI)
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Pamlab, Inc.
Major Depressive Disorder
The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone
The objective of this study is to evaluate the efficacy, safety and tolerability of cariprazine as an adjunctive treatment to antidepressant therapy (ADT) in patients with MDD who have had an inadequate response to…
- Trial name
- NCT03739203
- Testing
- Cariprazine, Antidepressant Therapy (ADT)
- Where
- 112 sites in United States, Canada and 6 more
- Volunteers
- 752 people
- Sponsor
- AbbVie
Major Depressive Disorder, Bipolar Depression
The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder
Rumination is significantly frequent in major depressive disorder. However, not a lot of studies have investigated the effects of repetitive transcranial magnetic stimulation on rumination and its electrophysiological correlates.
- Trial name
- NCT03468686
- Testing
- Bilateral rTMS, Unilateral rTMS (High frequency)
- Where
- Iran
- Volunteers
- 61 people
- Sponsor
- University of Tehran
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