Clinical trials: Major Depressive Disorder, completed
Schizophrenia, Schizoaffective Disorder
Decreasing Risk of Coronary Artery Disease in Schizophrenia by Omega-3 Fatty Acid Supplementation
The purpose of this study is to determine whether the administration of omega-3 polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA), can be useful both to reduce coronary artery disease (CAD) risk and illness…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Major Depression, Bipolar Disorder
- Trial name
- CAD (NCT00167310)
- Testing
- Eicosapentaenoic acid (omega-3 fatty acid)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Pittsburgh
Mental Disorder, Schizophrenia
A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion
The primary purpose of the study is to evaluate the positive detection accuracy (PDA) and detection latency measures of the D-Tect patch.
- Conditions
- Mental Disorder, Schizophrenia, Major Depressive Disorder, Bipolar I Disorder
- Trial name
- NCT06372210
- Testing
- Abilify MyCite®, D-Tect Patch
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depression, Depressive Disorders
A Study to Determine the Efficacy and Safety of 2 Doses of Org 34517 as Adjunctive Therapy in Subjects With Psychotic Major Depression (28130)(P05845)
The primary purpose of this study is to determine whether subjects with psychotic major depression benefit from adjunctive treatment with Org 34517.
- Conditions
- Depression, Depressive Disorders, Psychotic Disorders
- Trial name
- Hermes (NCT00212797)
- Testing
- Org 34517
- Volunteers
- 273 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depressive Disorder
Blame Rebalance fMRI Feedback Proof-of-concept
The investigators have shown that decoupling of brain networks when feeling guilty is the first potential functional neuroimaging biomarker of risk of major depression.
- Trial name
- GUIMRINFB1 (NCT01920490)
- Testing
- GUILT-INCREASE-CORRELATION, GUILT-STABILIZE-CORRELATION
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- D'Or Institute for Research and Education
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Major Depressive Disorder
Multidomain Intervention for Older Adults With Major Depressive Disorder
To assess the effectiveness of a 12-week multidomain intervention with contingency management for reducing depressive symptoms in older adults with major depressive disorder.
- Trial name
- NCT03095820
- Testing
- Supportive therapy, Multidomain intervention
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Ajou University School of Medicine
Mood Disorder, Bipolar Disorder
A Pilot Study on Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Bipolar Depression
This is a pilot project to study if repetitive Transcranial Magnetic Stimulation (rTMS) will benefit patients with bipolar depression safely.
- Conditions
- Mood Disorder, Bipolar Disorder, Major Depression, Depression
- Trial name
- TMS-BD (NCT00699218)
- Testing
- Magnetic Stimulator Rapid2 made by Magstim Company Ltd. U.K.
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Depressive Disorder
An Eight-week Study to Evaluate the Efficacy and Safety of Saredutant in Patients With Depression
The purpose of the study is to evaluate the efficacy and safety of saredutant (or SR48968C) in patients with depression. The primary objective is to evaluate the efficacy of a 100 mg dose of saredutant compared to placebo in…
- Trial name
- NCT00250601
- Testing
- Saredutant succinate (SR48968C)
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Sanofi
Major Depressive Disorder
Predictors of Treatment Outcome With Cognitive Behavioral Therapy for Depression
The purpose of this research study is to learn whether specific types of brain imaging and psychological testing can predict how much benefit patients with depression will receive from a well-studied psychotherapy for depression…
- Trial name
- NCT01922219
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Unipolar Major Depressive Disorder
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do not respond to either.
- Trial name
- NCT01875419
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Major Depressive Disorder
Opiate Suicide Study in Patients With Major Depression
To explore whether intravenous ketamine followed by buprenorphine produces more rapid and sustained anti-suicidal effects than ketamine followed by placebo, investigators will conduct a single study that will take approximately…
- Trial name
- AFSP (NCT04116528)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Major Depression
Physiologic Monitoring of Antidepressant Response
Primary: to identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are specifically associated with response to venlafaxine; Secondary: to…
- Trial name
- NCT00792168
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, Los Angeles
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with…
- Trial name
- VENTURA-2 (NCT05550532)
- Testing
- Aticaprant
- Where
- 131 sites in United States, Argentina and 12 more
- Volunteers
- 444 people
- Sponsor
- Janssen Research & Development, LLC
Depressive Disorder, Depression
Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major Depression
The purpose of this study is to examine the effectiveness of ethyl-eicosapentanoic acid (ethyl-EPA), an omega-3 fatty acid, in treating depression.
- Trial name
- NCT00096798
- Testing
- Ethyl-eicosapentanoic acid (ethyl-EPA)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Major Depressive Disorder
A Study of MD-120 in Patients With Depression
The purpose of this study is to verify the efficacy and evaluate the safety of 8-week once-daily oral administration of MD-120 in Japanese patients with depression.
- Trial name
- NCT04345471
- Testing
- Desvenlafaxine 100 mg, Desvenlafaxine 50 mg
- Where
- Japan
- Volunteers
- 615 people
- Sponsor
- Mochida Pharmaceutical Company, Ltd.
Liver-Stagnation and Spleen-Deficiency, Severe Major Depression Disorder
Effect of XingpiJieyu Formula on Mitochondrial Energy Metabolism in Severe Liver-Stagnation and Spleen-Deficiency Depression.
Study Title: Research on the therapeutic effect and clinical indicators of XingpiJieyu formula in the treatment of severe liver depression and spleen deficiency type depression based on abnormal mitochondrial energy metabolism…
- Trial name
- NCT07590609
- Testing
- XingpiJieyu Formula (XPJYF) + Escitalopram
- Where
- 2 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Major Depressive Disorder
Study of Mindfulness-Based Cognitive Therapy
Research aimed at assessing changes in depressogenic thinking and the ability to disengage from depressogenic thinking following Mindfulness-Based Cognitive Therapy
- Trial name
- MBCT (NCT00943033)
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 48 people
- Sponsor
- Binghamton University
Major Depression, Temporal Lobe Epilepsy
Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy
This is a research study evaluating the use of escitalopram (Lexapro®) for the treatment of major depression in subjects with temporal lobe epilepsy.
- Trial name
- NCT00595699
- Testing
- escitalopram
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Conrad, Erich J., M.D.
Major Depressive Disorder
Vagal Nerve Stimulation for Treatment Resistant Major Depression
The purpose of this study is to 1) explore whether vagal nerve stimulation (nVNS) using a hand- held non-invasive device (gammaCore™) works to treat depression and 2) to confirm gammaCore™'s safety profile.
- Trial name
- NCT04990687
- Testing
- gammaCore™
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Major Depressive Disorder
A Study of Patients With Major Depressive Disorder and Residual Apathy
The purpose of this study is to provide a comparison of the apathy, depression, and functional outcomes associated with switching to duloxetine or escitalopram in patients who have previously responded to treatment with a…
- Trial name
- NCT00985504
- Testing
- Duloxetine, Escitalopram
- Where
- 15 sites in Australia, Canada and 3 more
- Volunteers
- 483 people
- Sponsor
- Eli Lilly and Company
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