Clinical trials: Major Depressive Disorder, completed
Posttraumatic Stress Disorder, Major Depressive Disorder
rTMS for PTSD Comorbid With Major Depressive Disorder
The purpose of this study is to see how well a treatment called "Repetitive Transcranial Magnetic Stimulation" works for patients who struggle with symptoms of both posttraumatic stress disorder and major depressive disorder.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Transcranial Magnetic Stimulation, Repetitive
- Trial name
- NCT02273063
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Depression, Unipolar, Bipolar Disorder
Exercise for Depression
A randomized single-blinded prospective study to evaluate the efficacy of an individualized supervised 8-week exercise program in subjects with moderate to severe depressive episodes compared to treatment-as-usual
- Trial name
- EXDEP (NCT02874833)
- Testing
- Exercise
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Major Depressive Disorder
Study Evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) In The Treatment Of Peri- And Postmenopausal Women With Major Depressive Disorder (DVS 3364)
A multicenter, 10-week study to evaluate the efficacy and safety of 50 mg of desvenlafaxine succinate sustained-release formulation (DVS SR) versus placebo in the treatment of peri- and postmenopausal women with major depressive…
- Trial name
- NCT01121484
- Testing
- desvenlafaxine succinate sustained-release
- Where
- 44 sites in United States
- Volunteers
- 439 people
- Sponsor
- Pfizer
Major Depressive Disorder
EEG Biomarkers for Predicting Response to Antidepressant Therapy
The purpose of this study is to evaluate the potential early EEG predictors of an individual's response to treatment with antidepressant medications.
- Trial name
- NCT00289523
- Where
- 10 sites in United States
- Volunteers
- 375 people
- Sponsor
- Medtronic - MITG
Major Depressive Disorder
Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response.
In this project we aim to further refine indications for the use of the thyroid hormone - T3 for patients suffering from depression.
- Trial name
- NCT00421369
- Testing
- sertraline, triiodothyronine (T3), reboxetine
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Major Depressive Disorder, Soft Tissue Discomfort Syndrome
Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome
The objective of this study is to determine the time course of duloxetine efficacy on the symptoms of Major Depressive Disorder (MDD)and on the symptoms of Soft Tissue Discomfort Syndrome(STDS) via use of 24-hour Actigraph™…
- Conditions
- Major Depressive Disorder, Soft Tissue Discomfort Syndrome, Pain
- Trial name
- NCT01035073
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Depressive Disorder, Depression - Major Depressive Disorder
A Qualitative Analysis of Youth Responses to Depression Education Delivered on Social Media
Depression is a common mental disorder among adolescents, with increased rates during the COVID-19 pandemic. Despite its high burden, few young people seek professional help due to, among other things, low mental health literacy…
- Conditions
- Depressive Disorder, Depression - Major Depressive Disorder, Depression in Adolescence
- Trial name
- NCT07100548
- Testing
- "ich bin alles" (English: "I am everything")
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depressive Disorder
Escitalopram in Adult Patients With Major Depressive Disorder
This is a short-term study to evaluate the efficacy, safety, and tolerability of escitalopram in adult patients (18 to 65 years of age) with moderate to severe depression.
- Trial name
- NCT00668525
- Testing
- Escitalopram
- Where
- 45 sites in United States
- Volunteers
- 877 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder
A Study of LY2216684 and Digoxin in Healthy Subjects
The purpose of this study is to determine how much digoxin gets into the blood stream and how long it takes the body to get rid of it when given with LY2216684.
- Trial name
- NCT01266590
- Testing
- LY2216684, Digoxin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Deep Brain Stimulation for Refractory Major Depression
Despite many available treatments, there are patients with major depression who remain treatment refractory and chronically disabled.
- Trial name
- NCT00296920
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Depression, Recurrent Depression
Rumination Focused Cognitive Behavioral Therapy for Major Depression and Recurrent Depression
Group based cognitive behavioural therapy (CBT) is an effective treatment of depression, however, one third of patients do not respond satisfactorily (McDermut, Miller, \& Brown, 2001), and relapse rates around 30% have been…
- Trial name
- RuCoD (NCT02278224)
- Testing
- Group based rumination focused CBT, Group based CBT
- Where
- Denmark
- Volunteers
- 131 people
- Sponsor
- University of Copenhagen
Major Depressive Disorder (MDD)
Electrophysiological Biomarkers in Accelerated TMS for Depression
This study investigates whether physiological signals recorded during transcranial magnetic stimulation (TMS) can predict which patients with major depression respond to treatment.
- Trial name
- NCT07615387
- Testing
- Accelerated bilateral dmPFC-iTBS
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Depression
Low Intensity Versus Self-guided Internet-delivered Psychotherapy for Major Depression
BACKGROUND: Major depression will become the second most important cause of disability in 2020. Computerised cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment.
- Trial name
- NCT01611818
- Testing
- Low Intensity Internet-delivered psychotherapy, Self-guided Internet delivered psychotherapy, Improved treatment as usual
- Where
- 6 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Javier Garcia Campayo
Major Depressive Disorder
Phenotype Depression Study
To facilitate the development of a personalized approach to the treatment of patients with major depression, this study is designed to elaborate the clinical and neurobiological phenotype of depressed patients with increased…
- Trial name
- NCT01426997
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Emory University
Major Depression
Trial of Transcranial Direct Current Stimulation (tDCS)
Among antidepressant treatments, ECT stands as the most effective in treating acute depression. However, patient concerns with the cognitive side effects of ECT have encouraged the development of new and more focal forms of brain…
- Trial name
- NCT01346306
- Testing
- Eldith Company - direct current stimulator
- Where
- 2 sites in Australia, Singapore
- Volunteers
- 24 people
- Sponsor
- The University of New South Wales
Depression
Mifepristone Treatment for Patients With Non-psychotic Major Depressive Disorder Receiving Bilateral ECT
The purpose of this study is to see whether the medication mifepristone is an effective and tolerable treatment for increasing the clinical effectiveness of electroconvulsive therapy (ECT) and protecting cognitive function during…
- Trial name
- NCT00285818
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Major Depressive Disorder
A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder
This is a Phase 2 clinical study evaluating the safety and effectiveness of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT04479852
- Testing
- SP-624
- Where
- 39 sites in United States
- Volunteers
- 319 people
- Sponsor
- Sirtsei Pharmaceuticals, Inc.
Major Depressive Disorder (MDD)
6 Weeks Right-Amygdala TIS for Depression
The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes.
- Trial name
- NCT07059143
- Testing
- Nervio-X
- Where
- 3 sites in China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Major Depressive Disorder
A Randomised Double-Blind Trial of Targeted Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder
The study will involve a 3-week (15 session) randomized double-blind clinical trial of two repetitive transcranial magnetic stimulation (rTMS) conditions in patients with treatment resistant depression.
- Trial name
- NCT00168376
- Testing
- Transcranial Magnetic Stimulation
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The Alfred
Major Depressive Disorder, Social Anxiety Disorder
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response
Many patients with Major Depressive Disorder (MDD) and generalized Social Anxiety Disorder (gSAD) are treated with cognitive behavioral therapy (CBT) but few have meaningful improvement.
- Trial name
- NCT03175068
- Testing
- CBT, ST
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
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