Clinical trials: Major Depressive Disorder, completed
Autonomic Nervous System (ANS) Functioning and Mood State
Effects of Barefoot Running vs. in Shoes on Physiology and Mood
Aerobic exercise impacts bodily processes implicated in the pathophysiology of major depression. Consistent with these effects, aerobic exercise in general, and running in particular, has been repeatedly shown to have both…
- Trial name
- NCT01733381
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Depressive Disorder, Major
A Finnish Community Randomized Psychotherapy Effectiveness Study for Major Depression
Lohja Depression Treatment Study is a randomized treatment trial which compares three approaches for treatment of depression:1) Interpersonal Psychotherapy (IPT), 2) Psychoeducational Group Treatment ( PeGT) and 3) Treatment as…
- Trial name
- NCT02314767
- Testing
- Interpersonal Psychotherapy, Psychoeducational Group Therapy
- Volunteers
- 134 people
- Sponsor
- Helsinki University Central Hospital
Nicotine Dependence, Major Depressive Disorder
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
Persons who struggle with depression smoke at high rates and experience low quit rates in treatment. The best way to improve cessation treatment for this underserved population remains unknown.
- Trial name
- NCT02378714
- Testing
- Varenicline, BASC, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Post Traumatic Stress Disorder, Major Depression
Prevention of PTSD III: Neurocognitive Training of Emotional Regulation
The proposed work will evaluate the ability of neurocognitive retraining of executive functions and emotional regulation to reduce neurocognitive dysfunctions that follow trauma exposure and thereby prevent PTSD.
- Conditions
- Post Traumatic Stress Disorder, Major Depression, Anxiety Disorders
- Trial name
- NCT02085512
- Testing
- Neurocognitive retraining Web Based Intervention, Control, web-based tasks
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- NYU Langone Health
Depressive Disorder, Major, Positron-Emission Tomography
Molecular Imaging of Brain Inflammation in Depressive Disorders
In a number of neuropsychiatric disorders such as depression, both brain inflammation and glutamate mediated excitotoxicity (cell death through over-activated stimulation) are suspected to play a key role.
- Trial name
- DiME (NCT02983318)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, Bipolar Disorder
Insulin Resistance in Patients With Major Depression
The purpose of this study is to study the relationship between insulin and glucose action and neuropsychological functioning (memory, attention, general thinking abilities) in persons with depression.
- Conditions
- Depression, Bipolar Disorder, Mood Disorders, Insulin Resistance
- Trial name
- NCT01106313
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Stanford University
Depression
Major Depressive Disorder (MDD)
The purpose of this study is to assess the effectiveness of systematic screening for depression in high-risk patient participants in everyday clinical practice.
- Trial name
- NCT01662817
- Testing
- Intervention, Control
- Where
- Spain
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Study Comparing Discontinuation Symptoms Of DVS SR In Subjects With Major Depressive Disorder (MDD)
Study Comparing Discontinuation Symptoms in subjects with Major Depressive Disorder treated for 24 Weeks with Open-label 50 mg Desvenlafaxine Succinate Sustained-Release Formulation (DVS SR)
- Trial name
- NCT01056289
- Testing
- Desvenlafaxine Succinate Sustained-Release Formulation 50 mg, Desvenlafaxine Succinate Sustained-Release Formulation 25 mg
- Volunteers
- 480 people
- Sponsor
- Pfizer
Anxiety Disorders, Depression
A Waitlist-Controlled Trial of the Unified Protocol for the Treatment of Emotional Disorders in Adolescents
This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders.
- Trial name
- NCT00628888
- Testing
- Unified Protocol for Adolescents (UP-A)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Miami
Major Depressive Disorder
Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)
The objective of this study is to evaluate the efficacy, safety and tolerability of cariprazine as an adjunctive treatment to antidepressant therapy (ADT) in patients with MDD
- Trial name
- NCT01715805
- Testing
- Cariprazine, Antidepressant Therapy (ADT)
- Where
- 85 sites in United States, Puerto Rico
- Volunteers
- 1,022 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder, Anxiety
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
The purpose of this study is to investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in subjects with major depressive disorder and anxiety symptoms, who are experiencing an inadequate…
- Trial name
- NCT02013531
- Testing
- Brexpiprazole
- Where
- 21 sites in United States
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Severe Depressive Symptoms
Effectiveness of Internet-based Depression Treatment (EVIDENT) in Severe Depression
Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of severe depressive symptoms.
- Trial name
- NCT02178631
- Testing
- Deprexis, CAU
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Major Depressive Disorder
SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients
SPL026 (N,N-dimethyltryptamine [DMT] fumarate) is a psychedelic tryptamine being developed as a therapy for patients with major depressive disorder (MDD).
- Trial name
- NCT04673383
- Testing
- SPL026
- Where
- 2 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Small Pharma Ltd
Schizophrenia, Schizoaffective Disorder
Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI)
The major goal of this project is to adapt an existing group-based psychosocial program to enhance community functioning in older people with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00817154
- Testing
- HOPES-I
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophreniform Disorder, Schizoaffective Disorder
Open-label Ziprasidone Study for Psychosis Treatment in Adolescents
This open-label study will assess the medication Geodon® (Ziprasidone) in pediatric patients, aged 13-17, diagnosed with psychotic disorder.
- Conditions
- Schizophreniform Disorder, Schizoaffective Disorder, Psychosis, Depressive Disorder, Major
- Trial name
- NCT00421954
- Testing
- Ziprasidone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Major
Prediction of Antidepressant Effects of Electroconvulsive Therapy
Despite its successful use for more than 80 years, the mechanisms of action of electroconvulsive therapy (ECT) are still not fully understood.
- Trial name
- NCT05630469
- Testing
- Electroconvulsive therapy
- Where
- Austria
- Volunteers
- 23 people
- Sponsor
- Medical University of Vienna
Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression
The purpose of this study is to assess the impact of music on patients receiving a course of intravenous (IV) ketamine for treatment-resistant depression (TRD), both unipolar and bipolar.
- Conditions
- Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major, Unipolar Depression, Depression, Bipolar
- Trial name
- NCT04701866
- Testing
- Music
- Where
- 2 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Douglas Mental Health University Institute
Major Depressive Disorder
A Study of Brexpiprazole in Patients With Major Depressive Disorder
The purpose of this 14 week, randomized, double-blind, placebo controlled study is to assess the safety and efficacy of brexipiprazole to placebo as adjunctive treatment to an assigned open-label marketed antidepressant therapy…
- Trial name
- NCT03697603
- Testing
- Brexpiprazole
- Where
- Japan
- Volunteers
- 740 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Major Depressive Disorder
Intradermal Acupuncture Based on Changes in Biological Specificity of Acupoints for Major Depressive Disorder
Acupoints are the stimulus points and reactive points for acupuncture to treat diseases. Therefore, this study is designed to detect the pain threshold and temperature of biological specificities of acupoints in healthy control…
- Trial name
- NCT05524519
- Testing
- Basic treatment, PSA, TSA
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Post-Traumatic Stress Disorder, Depression
Group Intervention for Interpersonal Trauma
This study will assess the acceptability and effectiveness of a six-session, modular, repeating group for low-income women who have symptoms of depression and/or post-traumatic stress disorder following interpersonal trauma…
- Trial name
- NCT00348036
- Testing
- Group Intervention for Interpersonal Trauma, Information only
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Georgetown University
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