Clinical trials: Major Depressive Disorder, completed
Major Depressive Disorder, Anhedonia
Depression and Dopamine Transporter Function Study Using C-11 Altropane
Major depressive disorder (MDD) is often characterized by anhedonia and impaired ability to modulate behavior as a function of rewards.
- Trial name
- NCT01701141
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Schizoaffective Disorder, Schizophrenia
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
Testing an mHealth mobile interventionist texting program on illness management.
- Conditions
- Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT03062267
- Testing
- Mobile Interventionist
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- University of Washington
Major Depressive Disorder
ALK33BUP-201: Safety and Tolerability Study of ALKS 33-BUP (ALKS 5461) Administration in Subjects With MDD
This is a multicenter, randomized, double-blind, placebo-controlled, parallel, multiple dose study designed to evaluate the safety and tolerability of the co-formulation of ALKS 33 with buprenorphine (ALKS 5461) in subjects with…
- Trial name
- NCT01381107
- Testing
- ALKS 5461
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Alkermes, Inc.
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Cannabis Use Disorder, Major Depressive Disorder
Effects of Cannabis Abstinence on Symptoms and Cognition in Depression
The objective of this study is to assess the changes in symptoms and cognition that occur after a 28-day abstinence period in patients with comorbid Cannabis Use Disorder (CUD) and Major Depression (MDD).
- Conditions
- Cannabis Use Disorder, Major Depressive Disorder, Cognition
- Trial name
- NCT03624933
- Testing
- Weekly Behavioral Coaching Session, Contingency Management
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Schizoaffective Disorder
Health Care Management and Rehabilitation Skills Training for Treating Serious Mental Illness in Older People
This study will evaluate the effectiveness of a health management and supported rehabilitation intervention in treating serious mental illnesses in older people.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00169052
- Testing
- Health Care Management and Supported Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Major Depression, Dual Diagnosis
Ostrobothnia Depression Study (ODS). A Naturalistic Follow-up Study on Depression and Related Substance Use Disorders
Ostrobothnia Depression Study (ODS) was conducted in the South Ostrobothnia hospital district of Finland during 2009-2014. ODS is a naturalistic, open label, non-randomized follow-up study on depression and related substance use…
- Conditions
- Major Depression, Dual Diagnosis, Anxiety Disorders, Substance Related Disorders
- Trial name
- ODS (NCT02520271)
- Testing
- Behavioral Activation, Motivational Interview
- Where
- Finland
- Volunteers
- 242 people
- Sponsor
- Seinajoki Central Hospital
Pulmonary Disease, Chronic Obstructive, Depression
Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease
This study will evaluate the effectiveness of problem-solving therapy combined with treatment adherence procedures in treating older people with major depression and chronic obstructive pulmonary disease.
- Trial name
- NCT00601055
- Testing
- Problem Solving-Rx Adherence (PSA), PID-C
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- Weill Medical College of Cornell University
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Parents of Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05335564
- Testing
- General information about depression
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Major Depression
Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression
Women are more prone to depression at certain points of the life cycle, although the etiologic and therapeutic implications remain largely unknown1,2.
- Trial name
- NCT01824433
- Testing
- venlafaxine, fluoxetine
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Capital Medical University
Involutional Depression, Anxiety Disorders
MRI Study of Brain Activity and Risk for Depression in Adolescents
Anxiety in children of parents with major depressive disorder (MDD) poses a particularly high risk for later-life MDD. In adults, MDD involves dysfunction in prefrontal brain regions that regulate attention to emotional stimuli.
- Trial name
- NCT00047944
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Major
A Study Of A New Medicine (GW597599B) For The Treatment Of Major Depressive Disorder
A Placebo Controlled Study Evaluating Efficacy And Safety of Medication In Patients With Major Depressive Disorder (MDD)
- Trial name
- NCT00048204
- Testing
- GW597599B, paroxetine
- Volunteers
- 372 people
- Sponsor
- GlaxoSmithKline
Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder: A Randomized Controlled Trial
Role of Omega-3 Polyunsaturated Fatty Acid in the Management of Major Depressive Disorder.
Background: Patients with major depressive disorder have prominently been reported to be related with subnormal polyunsaturated omega-3 fatty acids levels, importantly low docosahexaenoic acid and eicosapentaenoic acid in plasma…
- Trial name
- NCT03732378
- Testing
- Omega-3 capsule
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Allama Iqbal Open University Islamabad
Major Depressive Disorders
The Effects of Transcranial Magnetic Stimulation on Retina and Choroidal Structures
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMSEYE (NCT06615804)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Postpartum Depression
A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)
The purpose of this study was to determine if SAGE-547 Injection infused intravenously at up to 90 micrograms per kilogram per hour (μg/kg/h) for 60 hours reduces depressive symptoms in participants with severe postpartum…
- Trial name
- NCT02942004
- Testing
- SAGE-547 60 μg/kg/h, SAGE-547 90 μg/kg/h
- Where
- 32 sites in United States
- Volunteers
- 138 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Depressive Disorder, Major, Cannabis Abuse
Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence
Adolescents who are diagnosed with major depressive disorder are often also diagnosed with marijuana dependence. Fluoxetine is an antidepressant medication currently used to treat young people who are diagnosed with major…
- Trial name
- CADY (NCT00149643)
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pittsburgh
Psychotic Disorders, Depressive Disorder
Genetics of Symptomatology and Treatment Response in Psychotic Major Depression
We hope to learn more about the biology of psychiatric illness with the hope of improving the diagnosis and treatment of such psychiatric conditions as major depression.
- Conditions
- Psychotic Disorders, Depressive Disorder, Depressive Disorder, Major
- Trial name
- NCT00691535
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depressive Disorder, Major
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
This study is open to adults with depression (major depressive disorder) for whom standard treatment with antidepressants alone does not work sufficiently.
- Trial name
- NCT04521478
- Testing
- BI 1358894, Quetiapine
- Where
- 120 sites in United States, Argentina and 12 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Alcohol Abuse, Schizophrenia
Contingency Management of Alcohol Abuse in the Severely Mentally ILL
The investigators will evaluate the efficacy of a comprehensive 12-week contingency management intervention for treating alcohol dependence for persons with severe mental illness who are seen within the context of a community…
- Conditions
- Alcohol Abuse, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- CMETG (NCT01567943)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Washington
Depression
Duloxetine Compared to Escitalopram and Placebo in the Treatment of Patients With Depression
The purposes of this study are to determine: The safety of duloxetine and any side effects that might be associated with it. How duloxetine compares to escitalopram and placebo (an inactive ingredient)
- Trial name
- NCT00073411
- Testing
- duloxetine, escitalopram
- Where
- United States
- Volunteers
- 675 people
- Sponsor
- Eli Lilly and Company
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