Clinical trials: Major Depressive Disorder, completed
Unipolar Depression
Neurofeedback as a Treatment Tool for Depression
The purpose of the study is to investigate whether neurofeedback delivered via functional magnetic resonance imaging signals can be used to train depressed patients to self-regulate emotion networks and whether this improves…
- Trial name
- NFD (NCT01544205)
- Testing
- fMRI-based neurofeedback
- Where
- 2 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- Cardiff University
Treatment Resistant Major Depressive Disorder
A Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive Disorder
To evaluate the efficacy and safety of AXS-05 relative to bupropion in subjects with treatment resistant major depressive disorder (MDD).
- Trial name
- STRIDE-1 (NCT02741791)
- Testing
- AXS-05, Bupropion
- Where
- 74 sites in United States
- Volunteers
- 312 people
- Sponsor
- Axsome Therapeutics, Inc.
Depression
Mifepristone Treatment for Patients With Non-psychotic Major Depressive Disorder Receiving Bilateral ECT
The purpose of this study is to see whether the medication mifepristone is an effective and tolerable treatment for increasing the clinical effectiveness of electroconvulsive therapy (ECT) and protecting cognitive function during…
- Trial name
- NCT00285818
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Major Depressive Disorder
A Study of LY2216684 in Healthy Participants Receiving Albuterol or Propanolol
The purpose of this study is to determine the effect of LY2216684 on heart rate of participants receiving Albuterol and Propranolol. Information about any side effects that may occur will also be collected.
- Trial name
- NCT01263197
- Testing
- LY2216684, albuterol, propranolol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder
Blood Biomarkers in Major Depression
Depression is a leading cause of disability worldwide, affecting nearly 16% of the general population. Its physiopathology remains unclear.
- Trial name
- NCT02209142
- Testing
- blood prelevement, psychometric data collection
- Where
- France
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Major Depressive Disorder
Imaging Predictors of Treatment Response in Depression
While there are many effective options for treating a major depressive episode, there are no clinical markers that predict the likelihood of remission with an initial trial of either an antidepressant medication or psychotherapy.
- Trial name
- NCT00367341
- Testing
- escitalopram, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Emory University
Adjunctive Treatment of Major Depressive Disorder
Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment
To evaluate the efficacy and safety of adjunctive pimavanserin compared to placebo in subjects with major depressive disorder who have an inadequate response to antidepressant therapy
- Trial name
- NCT03968159
- Testing
- Pimavanserin
- Where
- 85 sites in United States, Finland and 7 more
- Volunteers
- 298 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Depression
Rhodiola Rosea Therapy of Major Depressive Disorder
Prior research has shown that Rhodiola rosea may be an effective, short-term, anti-depressant therapy. This study will examine the anti-depressant effect of Rhodiola rosea vs.
- Trial name
- NCT01098318
- Testing
- Herbal extract, Sertraline, Lactose monohydrate
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine
The aim of the project is to establish a multimodal imaging approach for the investigation of the neural mechanisms underlying neuroreceptor regulation, glutamatergic metabolism and brain function that are of particular relevance…
- Trial name
- NCT03609190
- Testing
- Ketamine
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Major Depressive Disorder
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control…
- Trial name
- NCT00188942
- Testing
- Fluoxetine+Olanzapine, Olanzapine, Functional Magnetic Resonance Imaging
- Where
- 2 sites in Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Phenotype Depression Study
To facilitate the development of a personalized approach to the treatment of patients with major depression, this study is designed to elaborate the clinical and neurobiological phenotype of depressed patients with increased…
- Trial name
- NCT01426997
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Emory University
Bipolar Disorder, Involutional Depression
Study of the Psychological Development of Children of Parents With and Without Affective Disorders
This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to…
- Conditions
- Bipolar Disorder, Involutional Depression, Mood Disorder
- Trial name
- NCT00001170
- Where
- United States
- Volunteers
- 1,045 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Measurement-Based Care Vs. Standard Care for Major Depressive Disorder
Major depressive disorder (MDD) is one of the leading causes of disability worldwide, indicated as one of the two most disabling mental disorders by the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (Vos…
- Trial name
- MBC (NCT05431374)
- Testing
- Measurement Based Care (MBC), Control/Standard-care
- Where
- 6 sites in Pakistan
- Volunteers
- 150 people
- Sponsor
- Pakistan Institute of Living and Learning
Major Depression, Functional Dyspepsia
The Brain-Heart-Gut Connection
Major Depressive Disorder (MDD) often co-occurs with cardiovascular and gastrointestinal symptoms, highlighting the importance of the brain-heart-gut connection in developing comprehensive treatments.
- Conditions
- Major Depression, Functional Dyspepsia, Autonomous Dysfunction
- Trial name
- BHG-CONNECT (NCT06748274)
- Testing
- Transcranial Magnetic Stimulation (TMS), High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bern
Depressive Disorder, Major, Depression
Individualized Functional Connectivity Targeting in aiTBS for Depression
The goal of this clinical trial is to estimate the importance of neuroimaging in accelerated intermittent theta burst stimulation (aiTBS) for depression.
- Conditions
- Depressive Disorder, Major, Depression, Mood Disorders, Mental Disorder
- Trial name
- AINT (NCT05680727)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Schizophrenia, Schizoaffective Disorder
Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI)
The major goal of this project is to adapt an existing group-based psychosocial program to enhance community functioning in older people with serious mental illness (SMI).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- NCT00817154
- Testing
- HOPES-I
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depressive Disorder
An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression
This study will examine whether a highly specific and powerful 5-hydroxytryptamine 2A (5-HT2A) antagonist, M100907, combined with escitalopram, is responsible for an antidepressant effect.
- Trial name
- NCT00070694
- Testing
- MDL100.907
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression
Patients with an episode of depression in late life prescribed mirtazapine recruited from a clinical sample will be monitored for weight and receive a blood test during their usual course of treatment to determine polymorphisms…
- Trial name
- NCT01601002
- Testing
- Mirtazapine
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depressive Disorder, Treatment-Resistant
Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression
This study evaluated the efficacy and safety of the compound MIJ821 compared to placebo in patients aged from 18 to 65 years diagnosed with treatment-resistant depression. The study was conducted in the US and in Europe (Spain).
- Trial name
- NCT03756129
- Testing
- MIJ821, Ketamine
- Where
- 12 sites in United States, Spain
- Volunteers
- 70 people
- Sponsor
- Novartis Pharmaceuticals
Depression
Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression
This study will use measurements of depression symptoms and brain activity to determine what factors may influence an individual's response to treatment for depression.
- Trial name
- NCT00200902
- Testing
- Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro), Interpersonal Clinical Interaction (ICI)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of California, Los Angeles
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