Clinical trials: Major Depressive Disorder, completed
Depressive Disorder, Major
Coil Positioning in Navigated Transcranial Magnetic Stimulation Feasibility in Depression Patients Trial
The objective of this study is to evaluate the feasibility of adding a navigational system to traditional repetitive Transcranial Magnetic Stimulation (rTMS, referred to in this application as nTMS) as a way to establish and…
- Trial name
- CONFIDENT (NCT03795051)
- Testing
- Navigated Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Magstim
Depressive Disorder, Depressive Disorder, Major
Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits.
- Trial name
- NCT02741622
- Testing
- High aerobic intensity training (HIT), Long slow distance training (LSD)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Depressive Disorder, Major, Hepatitis C
Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1
The purpose of this study is develop and test a cognitive-behavioral intervention to prevent depression in methadone maintenance patients receiving medical treatment for hepatitis C.
- Trial name
- NCT00218556
- Testing
- Cognitive behavioral treatment for depression
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Major Depressive Disorder
Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression Disorder
Assessing psychiatric and physiological co-morbidity in TRD and non-TRD patients
- Trial name
- NCT00229398
- Sponsor
- Sheba Medical Center
Depression
Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression
The purpose of the study is to evaluate the efficacy of study drug (BMS-820836) as compared with continued Duloxetine/Escitalopram in the treatment of patients with treatment resistant depression (TRD).
- Trial name
- NCT01369095
- Testing
- Duloxetine, Escitalopram, BMS-820836
- Where
- 93 sites in United States, Argentina and 10 more
- Volunteers
- 976 people
- Sponsor
- Bristol-Myers Squibb
Major Depressive Episode, Inflammatory Bowel Diseases
Microglial Activation in Inflammatory Bowel Disease
The purpose of this study is to monitor microglial activation in participants with inflammatory bowel disease (IBD) and investigate the relationship that exists between these patients and their risk of acquiring major depressive…
- Trial name
- NCT03487926
- Testing
- [18F]FEPPA
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Depression
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action.
- Trial name
- NCT05571878
- Testing
- Humalog, Saline nasal spray
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Irritability
Study of Brexpiprazole as Adjunctive Treatment of Irritability in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy
To explore the anti-impulsive and anti-aggressive properties of brexpiprazole in a naturalistic setting of depressed patients with irritability.
- Trial name
- NCT01942785
- Testing
- Brexpiprazole
- Where
- 15 sites in United States
- Volunteers
- 55 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder, Bipolar 1 Disorder
Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine Learning
This study was designed to evaluate the efficacy of the mobile application named Circadian Rhythm for Mood (CRM), which was developed to prevent recurring episodes of mood disorders (major depressive disorders, bipolar disorders…
- Conditions
- Major Depressive Disorder, Bipolar 1 Disorder, Bipolar II Disorder
- Trial name
- NCT05400785
- Testing
- Circadian Rhythms for Mood (CRM) application - Active
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Hucircadian
Depression, Major Depressive Disorder
A Trial of AXS-05 in Patients With Major Depressive Disorder
A Phase 3, randomized, double-blind, placebo-controlled, multicenter trial of AXS-05 in patients with major depressive disorder (MDD).
- Trial name
- GEMINI (NCT04019704)
- Testing
- AXS-05
- Where
- 43 sites in United States
- Volunteers
- 327 people
- Sponsor
- Axsome Therapeutics, Inc.
LSD, Major Depressive Disorder
Mood Effects of Serotonin Agonists: Depression
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression.
- Conditions
- LSD, Major Depressive Disorder, Depression
- Trial name
- MESA-D (NCT07017478)
- Testing
- LSD
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Depressive Disorder, Major
Ketamine as an Alternative Treatment to ECT in Major Depressive Disorder
Developing more effective and faster acting antidepressant is of outmost clinical importance. Available antidepressant therapies have a delayed therapeutic effect.
- Trial name
- NCT02659085
- Testing
- Ketamine IV Infusion, ECT
- Where
- Sweden
- Volunteers
- 198 people
- Sponsor
- Pouya Movahed Rad
Major Depressive Disorder, Suicide
Pain, Reward, Attention and Neurocircuitry: Biomarkers of Suicidality
The ultimate aim of this study is to identify a biomarker of suicide risk in MDD by measuring the "hedonic spectrum" (pain and reward responsivity), attention and its associated brain structures using brain scans (fMRI and DTI)…
- Conditions
- Major Depressive Disorder, Suicide, Suicidal Ideation
- Trial name
- NCT02811198
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Depression, Major Depressive Disorder
Patient Dimensions as Predictors of Varied Treatment Responses and Outcomes in Patients With Major Depression
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00744406
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication (sertraline ,paroxetineor or venlafaxine)
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Episode, Covid19
Neuroinflammation in COVID-19 and Depression
The purpose of this study is to use state of the art brain imaging technology to investigate neuroinflammation in participants with depression after the respiratory symptoms of coronavirus disease 2019 (COVID-19) have passed.
- Trial name
- NCT04854785
- Testing
- [18F]FEPPA PET scan, [11C]SL25.1188 PET scan
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
LSD Therapy for Persons Suffering From Major Depression
Background: Major Depressive Disorder is one of the most prevalent mental illnesses, leading to substantial personal distress and economical consequences. Pharmacological Treatment is limited and relapse is frequent.
- Trial name
- LAD (NCT03866252)
- Testing
- LSD
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression
The Early Medication Change (EMC) Trial
The EMC trial investigates for the first time prospectively whether Major Depression Disorder patients with non-improvement after 14 days of antidepressive treatment with EMC are more likely to become remitters compared to…
- Trial name
- EMC (NCT00974155)
- Testing
- Escitalopram, venlafaxine, lithium, Escitalopram, venlafaxine
- Where
- Germany
- Volunteers
- 889 people
- Sponsor
- K. Lieb
Major Depressive Disorder, Unipolar Depression
RTMS Feasibility Study on Adolescent Depression Stimulation
This is an open-label study, in which all participants receives an active treatment with repetitive transcranial magnetic stimulation (rTMS) according to clinical protocol.
- Conditions
- Major Depressive Disorder, Unipolar Depression, Bipolar Depression
- Trial name
- NCT06126198
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Uppsala University
Depressive Disorder, Treatment-Resistant
DBS for Treatment Resistant Depression
The purpose of this study is to examine the effects of sub-callosal cingulate (SCC) deep brain stimulation (DBS) in patients with treatment resistant depression (TRD).
- Trial name
- CRIO-DBS (NCT01983904)
- Testing
- deep brain stimulation with short & long pulse width
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Depressive Disorder, Major
Melancholic Depression and Insomnia as Predictors of Response to Quetiapine in Patients With Major Depression
In essence the researchers are hoping to test two separate hypotheses (described below in the form of research questions). Therefore, the proposed analysis has been outlined according to each hypothesis.
- Trial name
- NCT03207438
- Testing
- Quetiapine 50 MG Extended Release Oral Tablet, Quetiapine Fumarate XR 150-300 mg
- Volunteers
- 1,790 people
- Sponsor
- University of Saskatchewan
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.