Clinical trials: Major Depressive Disorder, completed
Depression
Pharmacogenetic-Directed Treatment for Major Depression
Determine if antidepressant treatment guided by pharmacogenetic algorithm and interpretive report improves outcomes when compared with standard treatment without the availability of genetic information.
- Trial name
- NCT01261364
- Testing
- GeneSightRx, Treatment as usual
- Volunteers
- 50 people
- Sponsor
- Assurex Health Inc.
Severe Depressive Symptoms
Effectiveness of Internet-based Depression Treatment (EVIDENT) in Severe Depression
Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of severe depressive symptoms.
- Trial name
- NCT02178631
- Testing
- Deprexis, CAU
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Luebeck
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression
Predicting Effectiveness of Light Treatment for Winter Seasonal Affective Disorder
This study will evaluate a possible tool for predicting future effectiveness of bright light in treating seasonal affective disorder, winter subtype, and will examine secondary effects of bright light on cardiovascular risk…
- Trial name
- NCT00742365
- Testing
- Bright light
- Volunteers
- 41 people
- Sponsor
- University of Maryland, Baltimore
Artificial Intelligence (AI), Depression - Major Depressive Disorder
Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress
Emotional Distress, such as anxiety and depression, is an essential issue worldwide. There have been several evidence-based psychotherapies that are effective in improving emotional distress, such as Acceptance and Commitment…
- Conditions
- Artificial Intelligence (AI), Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT06735807
- Testing
- Generated AI-based intervention (Emohaa), group ACT, wailist (delayed intervenion)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central University of Finance and Economics, China
Major Depressive Disorder
Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-Adenosylmethionine
This study was a pharmacokinetic and safety evaluation of the S-adenosylmethionine formulation MSI-195, and a commercial comparator. The study was broken into two stages.
- Trial name
- NCT04623034
- Testing
- Ademetionine
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- MSI Methylation Sciences, Inc.
Depressive Disorder, Major, Major Depressive Disorder (MDD)
Depression Study In Elderly Patients
Major Depressive Disorder (MDD) Study in Elderly Outpatients
- Trial name
- NCT00067444
- Testing
- Paroxetine CR
- Where
- 46 sites in United States
- Volunteers
- 560 people
- Sponsor
- GlaxoSmithKline
Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
The goal of this observational study is to evaluate whether vagus nerve stimulation (VNS) intervention can reduce depressive symptoms and suicidality in adults with higher-grade treatment-resistant depression (HG-TRD)-individuals…
- Conditions
- Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder, Bipolar Depression
- Trial name
- VNS TRD HG-TRD (NCT07097025)
- Testing
- vagus nerve stimulation
- Where
- 2 sites in Israel
- Volunteers
- 19 people
- Sponsor
- Dr.Yoav Domany
Major Depression
Transcranial Magnetic Stimulation (rTMS) Accelerates the Response to Escitalopram in Major Depression
A doubleblind randomised trial with active versus sham rTMS in combination with escitalopram in patients with prior treatment resistant depression in an acute 12 weeks trial with subsequent 24 weeks study phase with active versus…
- Trial name
- NCT00149071
- Testing
- rTMS, TMS
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Hillerod Hospital, Denmark
Depressive Disorder, Major
A Study to Evaluate the Impact of Escitalopram on Quality of Life and Social Functionality in Patients With Major Depressive Disorder With Anxiety Symptom
The purpose of this study is to evaluate the impact of escitalopram on quality of life and social functionality in patients with major depressive disorder with anxiety symptom.
- Trial name
- NCT01870843
- Testing
- Escitalopram
- Where
- 10 sites in China
- Volunteers
- 261 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Schizophrenia, Bipolar Disorder
Cognitive Training to Improve Work Outcomes in Severe Mental Illness
This study will compare the efficacy of two types of supportive treatments for a program called Individual Placement and Support, which helps people with severe mental illnesses find and keep jobs.
- Conditions
- Schizophrenia, Bipolar Disorder, Depression
- Trial name
- NCT00895258
- Testing
- Individual placement and support plus cognitive training (IPS-CT), Individual placement and support plus enhanced support (IPS-ES)
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of California, San Diego
Major Depressive Disorder, Depression
Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine
The Investigators are conducting a research study to learn about the safety and benefit of using a medication called buprenorphine for patient with difficult to treat depression .
- Trial name
- (IRLGREY-B) (NCT02263248)
- Testing
- venlafaxine, buprenorphine
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depression
Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression
Women are more prone to depression at certain points of the life cycle, although the etiologic and therapeutic implications remain largely unknown1,2.
- Trial name
- NCT01824433
- Testing
- venlafaxine, fluoxetine
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Capital Medical University
Major Depressive Disorder
Aripiprazole Augmentation of SSRI Therapy in Treatment Refractory Depression
Our target population will have been adequately treated with one of three selective serotonin reuptake inhibitors (SSRIs; escitalopram, citalopram, or sertraline) for at least 8-12 weeks and continue to experience symptoms of…
- Trial name
- NCT00608543
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression
A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression
The purpose of this study is to determine whether a combination of naltrexone SR and bupropion SR is safe and effective in the treatment of major depression in overweight or obese subjects.
- Trial name
- NCT00624858
- Testing
- naltrexone SR 32 mg/ bupropion SR 360 mg daily
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Orexigen Therapeutics, Inc
Depressive Disorder, Major
Duloxetine in the Treatment of Melancholic Depression
The purpose of this study is to determine the optimal treatment strategy for MDD patients with melancholic features who do not respond to a standard daily dose.
- Trial name
- NCT00191685
- Testing
- duloxetine
- Where
- 23 sites in Australia, Canada
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Healthy
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients.
- Trial name
- NCT00369798
- Testing
- PET scan, Rolipram
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Unipolar Depression, Bipolar Depression
Voice Changes During ECT
Depressed patients talk differently when they are depressed compared to when they are well. But it is hard to actually measure what the differences are.
- Conditions
- Unipolar Depression, Bipolar Depression, Bipolar Disorder, Manic
- Trial name
- VAPRE (NCT04420793)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Serious Mental Illness, Schizophrenia
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients
Patients with severe mental illness (SMI) die younger than persons in the general population. Much of the excess mortality for SMI patients is attributable to cardiovascular disease, and is exacerbated by treatment with…
- Conditions
- Serious Mental Illness, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- FITNESS (NCT02188121)
- Testing
- Simvastatin, Losartan
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Mclean Hospital
Depressive Disorder, Major
Safety and Efficacy of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy, safety and tolerability of vortioxetine, once daily (QD), compared with placebo in adults with major depressive disorder.
- Trial name
- NCT01153009
- Testing
- Vortioxetine, Duloxetine
- Where
- 56 sites in United States
- Volunteers
- 614 people
- Sponsor
- Takeda
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