Clinical trials: Major Depressive Disorder (MDD)
Depressive Disorder, Depression
A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial
To compare the efficacy of brexpiprazole (flexible dose) with placebo as adjunctive therapy to an assigned open label antidepressant therapy (ADT) in the proposed subject population with MDD.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- NCT01727726
- Testing
- Brexpiprazole, Seroquel XR
- Where
- 76 sites in United States, Canada and 5 more
- Volunteers
- 2,182 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
MemFlex to Prevent Depressive Relapse
A wealth of research has demonstrated that they way in which the investigators recall our personal, autobiographical memories is influential in the course of depression.
- Trial name
- NCT02614326
- Testing
- Autobiographical Memory Flexibility (MemFlex) training, Psychoeducation
- Where
- 2 sites in United Kingdom
- Volunteers
- 70 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Major Depressive Disorder
Assessing Dopamine Transporter Occupancy in the Patients With Depression Brain With Toludesvenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)
This study was a single-arm, open-label clinical study to assess dopamine transporter occupancy in the brain of patients with depression using 11C-CFT positron emission tomography (PET).
- Trial name
- NCT06026917
- Testing
- Toludesvenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Mental Health Center
Depression, Major Depressive Disorder
eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients
The objective of this randomized controlled trial is to evaluate whether the investigators modernized IMPACT intervention for depression (eIMPACT), delivered before the onset of cardiovascular disease (CVD), reduces the risk of…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT02458690
- Testing
- Beating the Blues (BtB), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Indiana University
Major Depressive Disorder
Ketamine Anesthesia for Improvement of Depression in ECT
The purpose of this prospective randomized clinical trial is to determine if patients receiving ketamine as a part of general anesthesia during electroconvulsive therapy (ECT) rather than standard of care will have improvement in…
- Trial name
- KAID (NCT02752724)
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Puget Sound Health Care System
Bipolar Disorder, Major Depressive Disorder
Pioglitazone and Quetiapine XR Pharmacogenetic Study
Obtain phenotypic data and a DNA/blood sample from mood disorder patients undergoing pioglitazone or quetiapine XR treatment as a part of an IRB approved clinical trial conducted at the Mood Disorders Program.
- Trial name
- NCT01342380
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University Hospitals Cleveland Medical Center
Major Depressive Disorder
A Study of Sustained-Release Desvenlafaxine Hydrochloride for the Treatment of Major Depressive Disorder
A multicenter, 10-week study to evaluate the efficacy and safety of Sustained-Release Desvenlafaxine Hydrochloride versus Sustained-Release venlafaxine Hydrochloride in adult with major depressive disorder.
- Trial name
- NCT01977378
- Testing
- Sustained-Release Desvenlafaxine Hydrochloride, Sustained-Release Venlafaxine Hydrochloride
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Major Depressive Disorder, Mild Neurocognitive Disorder
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with…
- Conditions
- Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
- Trial name
- NCT06705478
- Testing
- Pramipexole ER, Escitalopram
- Where
- 41 sites in United States, Botswana and 12 more
- Volunteers
- 186 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Major Depressive Disorder
Slow-wave Sleep Deprivation in Depression
Sleep deprivation can acutely reverse depressive symptoms in patients with major depression. Although underlying mechanisms of the antidepressant action in sleep deprivation are unclear, many of these observations can be…
- Trial name
- NCT01189591
- Testing
- Slow-wave deprivation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Wisconsin, Madison
Depression
Pipamperone/Citalopram (PipCit)Versus Citalopram in the Treatment of Major Depressive Disorder(MDD)
The primary objective is to demonstrate whether the addition of pipamperone 5 mg twice daily (bd) to citalopram, 40 mg daily in patients suffering from MDD will improve the efficacy of citalopram 40 mg in these patients.
- Trial name
- NCT00672659
- Testing
- Citalopram + Pipamperone, Citalopram
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- PharmaNeuroBoost N.V.
Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major
Behavioural Activation Therapy and Esketamine for Resistant Depression
This is a randomized clinical trial to test the effectiveness of combining a proven psychological intervention called behavioural activation therapy alongside esketamine treatment for treatment resistant major depressive episodes…
- Conditions
- Depressive Disorder, Treatment-Resistant, Depressive Disorder, Major, Bipolar Disorder
- Trial name
- NCT06431386
- Testing
- Behavioural Activation (BA) Therapy, Esketamine
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- The Royal's Institute of Mental Health Research
Depression, Obesity
Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women
This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight.
- Trial name
- NCT00572520
- Testing
- Weight loss treatment, Behavior therapy for depression, Health education counseling
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Massachusetts, Worcester
Major Depressive Disorder
HypErthermia as an Additional Treatment for the Biology and Experience of Depression
This single-arm feasibility trial administered up to 8 weekly (early phase) or 4 bi-weekly (later phase) whole-body hyperthermia (WBH) sessions and 8 weekly cognitive behavioral therapy (CBT) sessions to adults aged 18 years or…
- Trial name
- HEATBED (NCT05041361)
- Testing
- Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia (WBH)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Depression, Depressive Disorder
Assessment of the Safety and Effectiveness of Cortical Stimulation in Subjects With Major Depressive Disorder
The purpose of this study is to assess the safety and effectiveness of cortical stimulation to the cerebral cortex of subjects who have suffered from treatment-resistant depression and have failed routine attempts at controlling…
- Trial name
- PROSPECT (NCT00380042)
- Testing
- Cortical Stimulation
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Northstar Neuroscience
Ketamine, Depression
Ketamine Co-induction for Patients With Major Depressive Disorder
Ketamine hydrochloride, an anesthetic medication, has been demonstrated to acutely and rapidly improve depressive symptoms but not yet been adequately studied for this effect when used as part of a general anesthetic for surgery.
- Conditions
- Ketamine, Depression, Anesthesia
- Trial name
- NCT03666494
- Testing
- Ketamine Hydrochloride, Propofol, Fentanyl
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Depression
The Impact of Psychological Interventions on Psychometric and Immunological Measures in Patients With Major Depression
The objective of this study is to compare the impact of i) Cognitive Behavioral Therapy (CBT) combined with exercise, ii)CBT combined with euthymic therapy, and iii) 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP)…
- Trial name
- NCT01464463
- Testing
- CBT - active, CBT - euthymic, CBASP
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Depression / Major Depressive Disorder, Food Insecurity
The Medically Tailored Groceries and Mental Health Study
This randomized controlled trial will test whether providing medically tailored groceries for 6 months can improve depressive symptoms among adults with depression and food insecurity.
- Trial name
- MTG : RCT (NCT07779707)
- Testing
- Medically Tailored, Home-delivered Groceries, Active Comparison Group: Monthly Grocery Gift Card
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Massachusetts, Worcester
Depression
Quality of Life and Its Related Factors of Patients With Major Depressive Disorder
The purpose of this study was to explore the quality of life and its related factors of patients with major depressive disorder. This study adopted cross-sectional research design.
- Trial name
- NCT00172549
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder
Brain Imaging Techniques That Predict Antidepressant Responsiveness
Do functional brain changes occur during Venlafaxine ER (extended release) versus Fluoxetine treatment and do changes in selective structures, such as the amygdala, predict treatment response?
- Trial name
- WyethKolden (NCT00909155)
- Testing
- Venlafaxine ERT, Fluoxetine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Major Depressive Disorder, Bipolar Disorder
High Intensity Interval Training in Severe Mental Illness
People experiencing severe mental illnesses (SMI), including schizophrenia, psychosis, bipolar disorder and major depressive disorder, are prone to poorer physical health and increased incidences of premature mortality when…
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT03959735
- Testing
- High Intensity Interval Training (HIIT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- King's College London