Clinical trials: Major Depressive Disorder (MDD), open to volunteers
Major Depressive Disorder (MDD)
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
Depression is a prevalent and debilitating disorder. The most common treatments are antidepressant medications and talking therapies. However, for many individuals, these are not their treatment of choice.
- Trial name
- HOME (NCT07228468)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- 6 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- King's College London
Major Depressive Disorder (MDD)
Gaze Contingent Attentional Reinforcement in Major Depressive Disorder
The main objective of this randomized controlled trial is to evaluate whether a gaze-contingent feedback task using negative reinforcement can serve as an effective attention-modification procedure and contribute to the treatment…
- Trial name
- NCT07364981
- Testing
- Aversive white noise, Music reward
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Major Depressive Disorder (MDD)
Salivary Oxytocin as a Biomarker of Psychedelic Treatment
This study aims to investigate whether oxytocin reactivity during a psychedelic session for MDD treatment predicts treatment response, specifically by examining its relationship with changes in flexibility and depressive symptoms.
- Trial name
- PAPOXT_MDD (NCT07345858)
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Geneva, Switzerland
Autism, Major Depressive Disorder (MDD)
Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1.
- Trial name
- NCT06821646
- Testing
- Positron Emission Tomography (PET), transcranial magnetic stimulation and electroencephalography(TMS-EEG)
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Electroconvulsive Therapy Augmented With Transcranial Magnetic Stimulation for Treatment Resistant Depression
The RTMSECT2 study was design to compare the application of electroconvulsive therapy augmented by transcranial magnetic stimulation.
- Trial name
- RMTSECT2 (NCT07324070)
- Testing
- Electroconvulsive therapy, Transcranial Magnetic Stimulation
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Major Depressive Disorder (MDD)
tVNS, Motivation, and Insulin Sensitivity
Disturbances in energy metabolism significantly increase the risk of developing major depressive disorder (MDD), especially in individuals with type 2 diabetes.
- Trial name
- NCT07198100
- Testing
- Transcutaneous non-invasive vagus nerve stimulation (tVNS), Oral glucose tolerance test (oGTT)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.
Clinical Study A. Retrospective Neuropathological Study of Synapse dysfunction. This is a cross-sectional study of patients retrospectively collected from existing postmortem collections and from existing collections of…
- Conditions
- Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant, Major Depressive Disorder (MDD), Bipolar Disorder (BD)
- Trial name
- NCT07234851
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder (MDD), Depression - Major Depressive Disorder
Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive Disorder
This study aimed to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) in patients with major depressive disorder (MDD) who exhibit suboptimal early response to antidepressant treatment.
- Trial name
- NCT06692361
- Testing
- FMT capsule, Escitalopram (Lexapro), Corn Starch capsules
- Where
- 9 sites in China
- Volunteers
- 214 people
- Sponsor
- Gang Wang
Treatment Resistant Depression, MDD
Psilocybin rTMS for Treatment Resistant Depression
The purpose of this study is to determine the safety and feasibility of sequencing psilocybin therapy with a short-duration, aiTBS protocol (Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT) in individuals with…
- Conditions
- Treatment Resistant Depression, MDD, Major Depressive Disorder, Recurrent Depression
- Trial name
- PSILOBSD (NCT06132178)
- Testing
- Psilocybin, Accelerated intermittent theta burst (aiTBS) rTMS treatment, Low-dose psilocybin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas at Austin
Adolescent, Major Depressive Disorder (MDD
Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study
This cohort study involves the dynamic collection of clinical information from adolescent patients with major depressive episodes (including both major depressive disorder and bipolar disorder), encompassing serum parameters…
- Conditions
- Adolescent, Major Depressive Disorder (MDD, Bipolar Disorder (BD)
- Trial name
- MAPS-IO (NCT07247344)
- Testing
- data collection and follow-up
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Ketamine-Enhanced Therapy for Individuals With Alcohol Use Disorder and Depression: A Pilot Study (KET-DUAL)
To assess the safety, feasibility and preliminary efficacy of ketamine-enhanced therapy (KET) for alcohol use disorder (AUD) and comorbid major depressive disorder (MDD) in an open-label, single arm, pilot clinical trial.
- Conditions
- Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD), Comorbidities and Coexisting Conditions
- Trial name
- KET-DUAL (NCT07247370)
- Testing
- Ketamine, Cognitive Behavioural Therapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- South West Sydney Local Health District
Major Depressive Disorder (MDD)
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have…
- Trial name
- NACC-D (NCT07212465)
- Testing
- Active Brainsway H7-Coil Deep TMS System
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Rotman Research Institute at Baycrest
Suicide Risk, Major Depressive Disorder (MDD)
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
The goal of this proof-of-concept clinical trial is to evaluate the initial safety, feasibility, and tolerability of the orexin mixed antagonist suvorexant in a sample of veteran adults with Major Depressive Disorder and elevated…
- Trial name
- NCT06854224
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marianne Goodman
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
Internet-Based Cognitive Behavioral Therapy With Treatment as Usual for Generalized Anxiety Disorder and Major Depressive Disorder in Taiwan (ICBT-TW)
This study aims to evaluate the effectiveness of internet-based cognitive behavioral therapy (ICBT) combined with treatment as usual (TAU) for adults diagnosed with generalized anxiety disorder (GAD) or major depressive disorder…
- Trial name
- ICBT-TW (NCT07177365)
- Testing
- Internet-Based Cognitive Behavioral Therapy (ICBT), Treatment as Usual (TAU) Only
- Volunteers
- 120 people
- Sponsor
- National Health Research Institutes, Taiwan
Major Depressive Disorder, MDD
Efficacy of Statins Among Major Depressive Disorder
The goal of this clinical trial is to learn if drug Rosuvastatin 10 mg works to treat MDD in adults. It will also learn about the safety of Rosuvastatin 10 mg .The main questions it aims to answer are: Does Rusovastatin lower the…
- Trial name
- NCT06698666
- Testing
- Rosuvastatin 10 mg tablet., Sertraline Pill
- Where
- Egypt
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Major Depressive Disorder (MDD)
Accelerated TMS for Treatment-Resistant ECT
This study investigates whether an additional treatment using transcranial magnetic stimulation (TMS) can help severely depressed patients who did not respond well to electroconvulsive therapy (ECT).
- Trial name
- A-TREC (NCT07115628)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Major Depressive Disorder (MDD)
PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
In the brain, certain nerve cells communicate using a chemical called acetylcholine. Acetylcholine is thought to be important for several functions including mood, memory and wakefulness.
- Trial name
- VATMDDNicotine (NCT07095205)
- Testing
- Nicotine transdermal patch, PET Scan with [18F] VAT
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Unipolar Depression, Major Depressive Disorder (MDD)
Validation of EmoDTx as a Digital Endpoint for Mood Monitoring in Adult Patients Suffering From Unipolar Depression
The aim of this study is to validate the EmoDTx as a digital tool for mood monitoring in adult patients with unipolar depression. The study is prospective, multicenter, and observational, with a single-arm approach.
- Conditions
- Unipolar Depression, Major Depressive Disorder (MDD), Depression
- Trial name
- EMC2FR (NCT06860165)
- Where
- 2 sites in France
- Volunteers
- 98 people
- Sponsor
- Emobot