Clinical trials: Major Depressive Episode (MDE), open to volunteers
Major Depressive Episode
Signature Response to Light Therapy in Unipolar and Bipolar Major Depressive Episode (MDE)
Major depressive episode (MDE) are severe and common psychiatric disorders that affect up to 20% of the general population. MDE cause a decrease in psychosocial functioning, quality of life, and is associated with a high rate of…
- Trial name
- SoLuRep (NCT07462637)
- Testing
- Light therapy
- Where
- France
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder (MDD) With Insomnia
Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia
Major Depressive Disorder (MDD) affects 5% of the global population and is the second leading cause of disability worldwide. Despite the widespread use of antidepressants, 50-60% of patients do not respond adequately after 8…
- Trial name
- CombiChronoS (NCT07120880)
- Testing
- AD + SHR + active LT and extended-release melatonin 2mg
- Where
- France
- Volunteers
- 184 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Episode (MDE), Beliefs
Belief Update: The Effects of Depression and Antidepressants in Older People
People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment…
- Conditions
- Major Depressive Episode (MDE), Beliefs, Beliefs About Future, Depression
- Trial name
- OLDBELIEFS (NCT07681492)
- Testing
- Response to questionnaire
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Bipolar Disorder (BD), Major Depressive Episode (MDE)
Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder
The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying…
- Conditions
- Bipolar Disorder (BD), Major Depressive Episode (MDE), Primary Care, Major Depression
- Trial name
- BIPOVITE (NCT07031817)
- Testing
- Venous blood sample for measuring blood biomarkers related to bipolar disorder, Standardized psychiatric assessment tools
- Where
- France
- Volunteers
- 623 people
- Sponsor
- University Hospital, Montpellier
Suicidal Thoughts and Behaviors, Major Depressive Episode (MDE)
Biomarker Discovery for Suicide Precision Circuit Therapeutics
This is a prospective observational biomarker study assessing changes in clinical, behavioral, neuroimaging, and neurophysiological measurer following ketamine/esketamine or electroconvulsive therapy (ECT) in adults with suicidal…
- Trial name
- NCT07723066
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Depression
Feasibility and Efficacy of rTMS in Depression in Patients With Autism Spectrum Disorder (ASD)
Depression is a common complication of Autism Spectrum Disorder (ASD): it is four times more prevalent in people with ASD than in the general population.
- Conditions
- Autism Spectrum Disorder, Depression, Major Depressive Episode (MDE)
- Trial name
- DEPASS'R (NCT07258914)
- Testing
- rTMS, rTMS treatment with intermittent Theta Burst (ITBS)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospital Center Guillaume Régnier
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Perimenopause, Major Depressive Episode (MDE)
The Immunobiological Mechanisms of Depression in Perimenopause
This project aims to identify immunobiological mechanisms underlying the development of depression during the perimenopause. During the perimenopause, the risk for recurrence of depression is increased 13-fold among women who…
- Trial name
- NCT07910552
- Where
- 4 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Van Andel Research Institute
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
The goal of this clinical trial is to learn if a drug called TNX-102 SL works to treat moderate to severe major depressive disorder in adults. It will also learn about the safety of TNX-102 SL.
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Depression
- Trial name
- HORIZON (NCT07621237)
- Testing
- TNX-102 SL
- Where
- 27 sites in United States
- Volunteers
- 360 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Major Depressive Episode (MDE), Unipolar Disorder
Evaluating the Therapeutic Potential of Focal Electrically Administered Seizure Therapy (FEAST) in the Treatment of Depression: A Multicenter Randomized Clinical Trial
A significant proportion of patients remain resistant to antidepressant therapies, even when treatment is well managed. Electroconvulsive therapy (ECT) is a well-established method for treating certain severe and resistant…
- Conditions
- Major Depressive Episode (MDE), Unipolar Disorder, Bipolar 1 Disorder
- Trial name
- FEAST-AFT (NCT07857122)
- Testing
- Stimulation by the Sigma ECT/FEAST device, Stimulation by Sigmastim ECT 200J device administered in right unilateral (RUL), Stimulation by Sigmastim ECT 200J device administered in bilateral (BT)
- Where
- 5 sites in France, Monaco
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier St Anne