Clinical trials: Major Lung Resection
Respiratory Distress Syndrome, Adult
Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS
This study evaluates the use of ultra-protective ventilation, where very low ventilation volumes are used, in patients with severe acute respiratory distress syndrome (ARDS) meeting criteria to nurse in the prone position.
- Trial name
- U-Protect (NCT02252094)
- Testing
- Prismalung, Ultra-protective ventilation, Conventional Lung Protective Ventilation
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Health System, Singapore
Lung Cancer
Robotic Assisted Major Lung Resection in Elderly Patients
The study is a retrospective observational study. The study is designed to be multicentric and it will analyze medical records from selected patients that underwent major lung resection using DaVinci surgical platform performed…
- Trial name
- ELDERLY (NCT06496386)
- Where
- 2 sites in Italy
- Volunteers
- 386 people
- Sponsor
- Scientific Institute San Raffaele
Infections and Respiratory Infectious
Oropharyngeal and Nasopharyngeal Decontamination With Chlorhexidine Gluconate in the Reduction of the Postoperative Morbidity and Mortality After Major Pulmonary Resections
Despite improvement of per and postoperative management, major pulmonary surgery continues to carry out a high morbidity with a significant mortality.
- Trial name
- CHLORHEX (NCT01613365)
- Testing
- Chlorhexidine Gluconate
- Where
- France
- Volunteers
- 474 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COPD Exacerbation
Extracorporeal Carbon Dioxide Removal in Severe Chronic Obstructive Pulmonary Disease Exacerbation
The conventional treatment for Severe acute exacerbation of Chronic obstructive pulmonary disease including noninvasive respiratory support, invasive respiratory support, etc, but there are many kinds of limitations and…
- Trial name
- NCT03692117
- Testing
- Extracorporeal Carbon Dioxide Removal
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Friendship Hospital
Lung Diseases, Obstructive
ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia
Patients with moderate to severe acute exacerbation of chronic obstructive pulmonary disease are often complicated with hypercapnia and respiratory failure, so they need to be admitted to ICU for monitoring and respiratory…
- Trial name
- NCT04842344
- Testing
- ECCO2R
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Li Xuyan
Solid Tumor, Small Cell Lung Cancer (SCLC)
Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid Tumors
The primary purpose of this study is to determine the safety, tolerability, and maximum tolerated dose (MTD) of EXS74539 (REC-4539) in participants with select solid tumors.
- Conditions
- Solid Tumor, Small Cell Lung Cancer (SCLC), High Grade Neuroendocrine Cancer, Small Cell Carcinomas of Non-lung Origin
- Trial name
- NCT07517198
- Testing
- EXS74539
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.
Non-small Cell Lung Cancer
VATS Major Lung Resection for Chinese Early-stage Non-small Cell Lung Cancer
Surgery may be the best treatment choice for early stage non-small cell lung cancer. And VATS major lung resection have been preferred as a standard radical procedure for early stage non-small cell lung cancer (NSCLC).This study…
- Trial name
- NCT01707888
- Testing
- Thoracoscopy/VATS
- Where
- 6 sites in China
- Volunteers
- 500 people
- Sponsor
- Peking University People's Hospital
Right Ventricular Dysfunction, Pneumonectomy; Status
Right Ventricle Function After Major Right Lung Resection
Major lung resection is associated with high post-operative morbidity and mortality and significant long-term decreased functional capacity, especially due to cardiorespiratory complications.
- Trial name
- RIVER (NCT04167241)
- Testing
- Echocardiography
- Volunteers
- 50 people
- Sponsor
- Humanitas Clinical and Research Center
Postoperative Air Leak
Prolonged Air Leakage After Major Lung Resection
The goal of this prospective randomized controlled trial is to investigate the clinical effects of autologous blood pleurodesis in the treatment of pulmonary air leaks on the first postoperative day following VATS pulmonary…
- Trial name
- PRAL (NCT05638113)
- Testing
- Pleural injection of autologous blood
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital
Pain, Postoperative, Lung Neoplasm
PATHOS Study Pain Assessment in Thoracic Oncologic Surgery
A randomized prospective trial to assess whether the use of loco regional anesthesia as adjuvant analgesic therapy is more effective of intravenous analgesia only.
- Trial name
- PATHOS (NCT03134729)
- Testing
- Ropivacaine for Serratus Plane Block (SPB)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Lung Surgery, Right Ventricular Function
RIght VEntricle Response to Major Lung Resection in VATS and Robotic Surgery
Major pulmonary resection is associated with high postoperative morbidity and mortality, mainly due to cardiorespiratory complications.
- Trial name
- RIVER-2 (NCT07362342)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas