Clinical trials: Major Non-cardiac Surgery
Coronary Artery Disease
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac…
- Trial name
- NCT00286585
- Testing
- Inhalational anesthetic, Intravenous anesthetic, propofol
- Where
- 3 sites in Switzerland
- Volunteers
- 385 people
- Sponsor
- University Hospital, Basel, Switzerland
Delirium
Avoidance of Delirium in Older Patients After Major Non-cardiac Surgery
This study is designed to compare the incidence of postoperative delirium in older patients after major non-cardiac surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group and a…
- Trial name
- ADOM (NCT01827501)
- Testing
- PulsioflexTM Monitoring
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- Technical University of Munich
Diabetes Mellitus, Coronary Heart Disease
Long-term Mortality in Diabetics Undergoing Major Surgery
Patients with CAD and diabetes mellitus have a better prognosis than patients with CAD and no diabetes mellitus. In acute coronary syndrome patients with an insulin therapy had a better survival than patients with oral…
- Conditions
- Diabetes Mellitus, Coronary Heart Disease, Major Non-cardiac Surgery
- Trial name
- NCT00286572
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University Hospital, Basel, Switzerland
Surgery
Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?
The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.
- Trial name
- NCT00942786
- Where
- Austria
- Volunteers
- 297 people
- Sponsor
- Medical University of Graz
Cardiovascular Diseases, Risk Reduction Behavior
Long Term Cardiovascular Disease Event Risk for Patients Undergoing Major Non-Cardiac Surgery
The goal of this observational study is to learn whether the healthy lifestyle choices made around surgery can influence an individual's long term risk of developing cardiovascular disease.
- Trial name
- CVD-10y-postop (NCT05732714)
- Testing
- Healthy lifestyle behaviors around the time of surgery
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Neonatal Patients Undergoing Major Non-cardiac Surgery, Congenital Anomaly
Neonatal Enhanced Recovery After Surgery (ERAS) Outcomes Study
The goal of this observational study is to improve the way newborn babies are cared for before, during, and after major surgery. Surgery can be very stressful on a baby's body.
- Trial name
- NEO (NCT07771478)
- Testing
- Pre-nERAS Guideline Implementation Intervention, Multifaceted Implementation of nERAS Guideline Intervention
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 400 people
- Sponsor
- The Hospital for Sick Children
Postoperative Cardiovascular Complications
Preoperative BNP as Biomarker of Postoperative Cardiovascular Complications
BNP is a hormone that predicts preoperatively the occurrence of postoperative cardiovascular complications. In practice, the problem is that the practitioner don't know the most opportune moment for the preoperative sample or…
- Trial name
- BNP (NCT02570607)
- Testing
- BNP dosage
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Fluid Therapy
The Effect of Goal-directed Therapy Guided by Stroke Volume Variation and Cardiac Index in Non-severe Surgical Patients
To evaluate the application of fluid-infusion therapy with the combination of stroke volume variation (SVV) and cardiac index (CI) as the primary judgment in non-severe patients underwent resection of gastrointestinal tumor.
- Trial name
- NCT02841046
- Testing
- cardiac index, Stroke Volume Variation
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Surgical Procedure, Unspecified
Non-invasive Assessment of Arterial Blood Pressure and Functional Hemodynamic Parameters
Cardiac output can be monitored using different invasive devices. Nexfin HD is a new, noninvasive device that uses model flow technology to measure stroke volume and thus computes cardiac output (CO).
- Trial name
- NCT01292759
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Johannes Gutenberg University Mainz
Mortality After Major Non Cardiac Surgery
Intraoperative Dobutamine Stress Test With Speckle Tracking to Decrease Postoperative Mortality (ISTMO)
Perioperative adverse cardiovascular events are the leading cause of morbidity and mortality after noncardiac surgery. The implications of perioperative cardiac complications on morbidity and mortality, in-hospital and long-term…
- Trial name
- ISTMO (NCT03365726)
- Testing
- Dobutamine stress test with trans-esophageal echocardiography
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Major Non-cardiac Surgery
Effects of Perioperative Administration of Dexamethasone on Postoperative Complications and Mortality After Non-cardiac Major Surgery
Postoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery.
- Trial name
- PACMAN (NCT03218553)
- Testing
- Dexamethasone
- Where
- 29 sites in France
- Volunteers
- 1,222 people
- Sponsor
- Nantes University Hospital
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Postoperative Delirium
Risk Factors for Postoperative Delirium in Elderly Patients Undergoing Major Non-Cardiac Surgery in Singapore
The primary aim is to establish the risk factors, in particular the modifiable risk factors, for the development of POD in elderly patients undergoing major non-cardiac surgery in a tertiary hospital in Singapore.
- Trial name
- NCT04617210
- Testing
- Neurocognitive tests and blood taking
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Myocardial Injury
Myocardial Injury and Postoperative Complications
To determine whether perioperative myocardial injury is associated with adverse outcome in patients scheduled for major abdominal surgery.
- Trial name
- MICOLON (NCT02150486)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- St. Antonius Hospital
Intraoperative Hypotension, Acute Kidney Injury
Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension
In order to reduce the incidence of IOH, various goal-directed therapy (GDT) protocols have already been introduced with success regarding the reduction of postoperative AKI and MINS.
- Conditions
- Intraoperative Hypotension, Acute Kidney Injury, Myocardial Injury After Non-cardiac Surgery
- Trial name
- Clearsight (NCT06291714)
- Testing
- GDT-based hemodynamic management based on Clearsight device
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Giessen
Pulmonary Hypertension
Preoperative Pulmonary Systolic Pressure and Outcome After Non-cardiac Surgery:Threshold Analysis
The linear or nonlinear relationship of pulmonary systolic pressure and cardiovascular and kidney outcome after non-cardiac surgery is unknown.
- Trial name
- NCT03974919
- Testing
- NO intervention required
- Where
- China
- Volunteers
- 19,000 people
- Sponsor
- Peking University First Hospital
Major Adverse Cardiac-cerebral-kidney Event
MACE and First Operating Room Systolic Blood Pressure in Patients Undergoing Non-cardiac Surgery Implications for the Hypertension Threshold
To find the threshold of First operating room SBP above which MACE risk increases.
- Trial name
- NCT03185598
- Volunteers
- 90,342 people
- Sponsor
- Peking University First Hospital
Thrombosis
The Association Between Platelet Inhibition and Perioperative Major Adverse Cardiac Events In Post-Percutaneous Coronary Intervention (PCI) Patients Undergoing Non-Cardiac Surgery
This prospective, multicentre, observational study aims to test pre-operative platelet function when taking anti-platelet medications.
- Trial name
- NCT01707459
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- University Health Network, Toronto
Aging, Postoperative Cognitive Dysfunction
Postoperative Cognitive Function and EEG
In the elderly patients undergoing elective non-cardiac major surgery, the differences of EEG parameters between those with and without postoperative cognitive dysfunction were observed to determine the characteristic changes of…
- Conditions
- Aging, Postoperative Cognitive Dysfunction, EEG With Periodic Abnormalities
- Trial name
- POEM (NCT04219033)
- Testing
- EEG(Electroencephalogram) change
- Where
- 18 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Air Force Military Medical University, China
Cognitive Function Abnormal, Anesthesia
Perioperative Changes of Cerebrovascular Autoregulation and Association With Cognitive Function
Cerebral blood flow is tightly regulated to ensure constant cerebral perfusion independently from systemic blood pressure fluctuations.
- Conditions
- Cognitive Function Abnormal, Anesthesia, Surgery
- Trial name
- NCT04101006
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf