Clinical trials: Major Non-cardiac Surgery
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Major Depressive Disorder, Surgery
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery.
- Conditions
- Major Depressive Disorder, Surgery, Orthopedic Disorder
- Trial name
- NCT03861988
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Goal Directed Therapy, Postoperative Morbidity
Risk Factors for Postoperative Complications in Major Non-cardiac Surgery: Post-hoc Analysis of the OPHIQUE Multicentre Study
Post-operative morbidity and mortality is related to many factors related to the patient's condition, the intra-operative period and the optimisation of intra-operative haemodynamic and respiratory parameters.
- Conditions
- Goal Directed Therapy, Postoperative Morbidity, Individualised Target, Postopera Mortality
- Trial name
- MULTIPAS (NCT05824260)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Post-operative Delirium
Interest in Combining Intraoperative ElectroEncephaloGram (EEG) With Assessment of Frailty to Predict Postoperative Delirium in Patients Aged >75 Years Undergoing Major Non-cardiac Surgery
Post-operative delirium (POD) is known to be independently associated with pre-operative frailty, pre-operative cognitive status and per-operative ElectroEncephaloGram (EEG).
- Trial name
- NCT06510140
- Testing
- Detection of the Post-operative delirium (POD)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Anesthesia, Neurocognitive Disorders
Neurocognitive Disorders After Major Surgery in Elderly
The objective of the study is to investigate, in patients aged 70 years and over undergoing major non-cardiac surgery, the effect of electroencephalic (EEG)-guided anesthesia on postoperative neurocognitive disorders when…
- Trial name
- POEGEA (NCT04825847)
- Testing
- BIS monitor, Control group
- Where
- Canada
- Volunteers
- 314 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Overall Survival
Intraoperative Dexmedetomidine and Long-term Outcomes in Elderly After Major Surgery
This is a 3-year follow-up of patients enrolled in a previous randomized controlled trial which showed that intraoperative dexmedetomidine reduced delirium in elderly patients after major non-cardiac surgery.
- Trial name
- NCT04111926
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Peking University First Hospital
Perioperative/Postoperative Complications, Surgery
Validity of Aortic Pulse Wave Velocity in Predicting the 6- Minute Walking Test Before Major Non-cardiac Surgery
Methods: Prospective observational study in adult patients requiring preoperative evaluation Objectives: To determine the correlation between the aortic pulse wave velocity (AoPWV) and the distance walked in the 6-minute walk…
- Conditions
- Perioperative/Postoperative Complications, Surgery, Exercise Tolerance
- Trial name
- 6WAVE (NCT03866915)
- Testing
- Aortic pulse wave velocity measurement, 6 minutes walking test
- Where
- 3 sites in Spain
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Grupo Español de Rehabilitación Multimodal
Mesenteric Ischemia
Microcirculation During Extracorporeal Circulation
Digestive tract is supposed to be the motor of multiple organ failure. In ICU patients, mesenteric ischemia appears even when macrocirculatory parameters are controlled especially in our experience in patients coming in ICU after…
- Trial name
- CITRON4 (NCT01389947)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Surgery
Evaluation of Indirect Measurement of Respiratory Quotient in Non-cardiac Major Surgery (The BAR Study)
Demonstrate the ability of the RQ, measured indirectly from the anesthesia ventilator, to predict the occurrence of anaerobic metabolism in patients operated of major non-cardiac surgical operation in the operating room
- Trial name
- NCT03471962
- Testing
- surgery
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bleeding, Thrombosis
Occurrence of Bleeding and Thrombosis During Antiplatelet Therapy in Non-cardiac Surgery
Research questions: 1. What is the absolute risk reduction for in-hospital major adverse cardiac events (MACE) associated with the use of dual anti-platelet therapy as compared with aspirin alone in this population? 2.
- Conditions
- Bleeding, Thrombosis, Cardiac Events
- Trial name
- OBTAIN (NCT01358422)
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 830 people
- Sponsor
- European Society of Anaesthesiology
Perioperative Myocardial Infarction, Disability
TEAMS (Troponin Elevation After Major Surgery) Study
Background to main study question: Cardiac complications are a common cause of morbidity after non-cardiac surgery. Patients with perioperative myocardial injury (both MI, and lower levels of cardiac troponin elevation)…
- Trial name
- TEAMS (NCT02146560)
- Where
- Canada
- Volunteers
- 267 people
- Sponsor
- University Health Network, Toronto
Inflammation, Perioperative Morbidity
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))
Evidence thus suggests that steroid administration, tight glucose control, and avoidance of deep anesthesia may decrease perioperative morbidity by reducing the inflammatory response to surgery.
- Trial name
- NCT00995501
- Testing
- Dexamethasone Sodium Sulfate, Insulin, anesthesia management
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- d sessler
Surgery, Cardiac Death
Endothelial Dysfunction and Non-cardiac Surgery
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
- Conditions
- Surgery, Cardiac Death, Stroke, Myocardial Injury
- Trial name
- NCT05778981
- Testing
- FMD - Troponin measurement
- Where
- Chile
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chile
Surgery
Association Between Perioperative Platelet Function and Major Adverse Perioperative Events
This study will examine the degree of blood thinning (platelet function) in patients coming for non-cardiac surgery on antiplatelet agents using platelet function tests called thromboelastography (TEG) and platelet mapping assay…
- Trial name
- NCT00901030
- Testing
- Blood drawn
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Patient With Clinically Indicated Invasive Monitoring
ClearSight System CHN Study
The purpose of this clinical trial is to demonstrate that cardiac output (CO) as determined with the Clinical Platform (Model:EV1000A, Software Version:1.9) in a noninvasive manner is comparable to CO as determined by Pulmonary…
- Trial name
- NCT03807622
- Testing
- EV1000NI Clinical Platform: Noninvasive Hemodynamic Monitoring utilizing ClearSight System
- Where
- 3 sites in China
- Volunteers
- 125 people
- Sponsor
- Edwards Lifesciences
Myocardial Infarction
Predicting Myocardial Infarction After Abdominal Surgery: Clinical Scores & Biomarkers
All patients undergoing non-cardiac surgery who met the inclusion criteria underwent a preoperative evaluation using specific assessment tools.
- Trial name
- NCT06767943
- Testing
- 12-lead electrocardiography
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Aortic Stenosis, Bicuspid Aortic Valve (BAV)
TAVR vs. SAVR Study of VitaFlow Liberty® for Severe BAV Stenosis
To evaluate the safety and effectiveness of the Transcatheter aortic valve and retrievable delivery system (VitaFlow Liberty®) for the treatment of severe bicuspid aortic valve (BAV) stenosis.
- Trial name
- PROMIS-BAV (NCT06597188)
- Testing
- VitaFlow Liberty, Commercially available surgical bioprosthetic valve
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Shanghai MicroPort CardioFlow Medtech Co., Ltd.
Mitral Annular Calcification, Mitral Stenosis
The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).
A prospective multicenter study enrolling high surgical risk patients with severe mitral annular calcification (MAC) and symptomatic mitral valve dysfunction (severe stenosis, ≥ moderate to severe regurgitation, or mixed ≥…
- Conditions
- Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
- Trial name
- MITRAL-II (NCT04408430)
- Testing
- Transseptal ViMAC
- Where
- 17 sites in United States, Mexico
- Volunteers
- 210 people
- Sponsor
- Mayra Guerrero